DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4199 and aif1

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001342910.1	Gene:	aif1 / 3361554	PomBaseID:	SPAC26F1.14c	Length:	611	Species:	Schizosaccharomyces pombe

Alignment Length:	617	Identity:	187/617 - (30%)
Similarity:	302/617 - (48%)	Gaps:	94/617 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KKEKSTGGAVGSYQSKCSNQSPSTTMSTEESSPDSEYTSAVPVDCRVTDLKENEMKQVDFDEDT- 80
            ||::..|..:|....:.|:.|                      ..:...|.:.:..|::||..:
pombe    21 KKDRILGLQLGKQPFRMSSSS----------------------GLKQQGLAQKKKFQLEFDPSSV 63

  Fly    81 ----------------RVLLVKQNDRLLAVGAKCTHYGAPLQTGAL-GLGRVRCPWHGACFNLEN 128
                            .||||:..:...|...||:||||||..|.: ..|.:.|||||||||...
pombe    64 SKNGTKTEAKVVGTEFGVLLVRARNTYFATAGKCSHYGAPLAKGVVTSDGHIVCPWHGACFNAAT 128

  Fly   129 GDIEDFPGLDSLPCYRVEVGNEGQVML-------------------RAKRSDLVNNKRLKNMVRR 174
            ||:||.|.:.:|..:.|....:|.:.:                   |.|.:::.|    |..|..
pombe   129 GDVEDTPAIAALRTFPVTEEGDGSLWIEVEDKNDNGASVLQPEGCWRNKATEVYN----KGSVET 189

  Fly   175 KPDDQRVFIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDE 239
            :.....| .::|||...:||.|.:|::.|.|::....|||.:||||.|:||::..:|.:|..|.:
pombe   190 EVTAPHV-CIIGGGKGASVAAEYLREKNFKGKITIFTREDEVPYDRPKLSKSLLHDISKLALRSK 253

  Fly   240 EFYKEYDIELWQGVAAEKLDTAQKELHCSNGY--VVKYDKIYLATGCSAFRPPIPGVNLENVRTV 302
            |:|.:.||.........|:|.|:|:::|.:..  ...|.|:.||||....:.||||::.:||..:
pombe   254 EYYDDLDISFHFNTDVTKIDLAEKKIYCGSDEKPTESYTKLILATGGEPNKLPIPGLDSKNVYLL 318

  Fly   303 RELADTKAILASITPES----RVVCLGSSFIALEAAAGLVSKVQSVTVVGRENVPLKAAFGAEIG 363
            |.:||... ||::|.|:    .:|.:|||||.||.|  :|.|..:|:|:|.|::|.:...|.|:|
pombe   319 RSIADASK-LAAVTTEAGDKKNIVIIGSSFIGLELA--VVLKDHNVSVIGMESIPFEKVMGKEVG 380

  Fly   364 QRVLQLFEDNKVVMRMESGIAEI--VGNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKS 426
            ..:..|.|.|.:...:|:.|.|:  ..|:..|...:||.|...:|.|::||..|.|.|.::|. :
pombe   381 TALKALHEQNGIAFYLENSIKEVKTSSNDSSKAEHIVLKDGQSIPADVVILAAGVKPNLRYLG-N 444

  Fly   427 GVKVNRNGSVDVTDFLE-SNVPDVYVGGDIANAHIHGL------AHDRVNIGHYQLAQYHGRVAA 484
            .|.:.::|.|.|.:... ....|||..||||:|...||      :|.|:.  |:.:|...|||||
pombe   445 AVSLEKDGGVKVDEHCRVLGAEDVYAVGDIAHAPFAGLPSSGEKSHTRIE--HWDVAGNLGRVAA 507

  Fly   485 INMCGGVK----KLEAVPFFFTLIFGKGIRYAGHGS---YKDVIIDGSMEDFKFVAYFINEADTV 542
            .::..|.|    .....|:|:: ..||.:||.|:.:   :.||:|.||:.|:||..:| .:.:.|
pombe   508 DHILFGNKAGYTTKSFTPYFWS-AQGKQLRYCGNNAAEGFDDVVIQGSLSDYKFACFF-TKGEKV 570

  Fly   543 TAVASCGRDPIVAQFAELISQGKCLGRGQIED 574
            ..|.|..:||:|:|.|.|..:.....:.|:::
pombe   571 VGVCSIMKDPVVSQCARLFIKDAMPSKSQLKE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	36/112 (32%)
		Pyr_redox_2	183..465	CDD:285266	102/296 (34%)
		Pyr_redox	320..402	CDD:278498	29/83 (35%)
		Reductase_C	505..577	CDD:291425	24/73 (33%)
aif1	NP_001342910.1	Rieske_AIFL_N	58..154	CDD:239560	34/95 (36%)
		Pyr_redox_2	194..499	CDD:311792	106/311 (34%)
		Reductase_C	526..>576	CDD:317198	17/51 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I867
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I708
OMA	1	1.010	-	-		QHG58553
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm47043
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	LDO	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
TreeFam	1	0.960	-	-
	13	12.860