DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4199 and AIF

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	113/486 - (23%)
Similarity:	198/486 - (40%)	Gaps:	95/486 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 AKRSDLVNNKRLKNMV----RRKPDDQRV-----FIVVGGGPSGAVAVETIRQEGFTGRLIFVCR 212
            ||:::....:|.:.:|    ...|..:.:     ::::|||.:...|...|:....|.:::.:..
  Fly   223 AKKAEAEEEERKRRLVAGLATSPPSSEDLPKHVPYLIIGGGTAAFSAFRAIKSNDATAKVLMISN 287

  Fly   213 EDYLPYDRVKISKAM------NLE-IEQLRFR-------------DEEFYKEYDIE--------L 249
            |...||.|..:||.:      |.: |:..||:             ||.|....|::        :
  Fly   288 EFRKPYMRPPLSKELWYTPNPNEDPIKDYRFKQWTGSERSLFFEPDEFFIDPEDLDDNANGGIAV 352

  Fly   250 WQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPI-----PGVNLENVRTVRELADTK 309
            .||.:.:|:|..::.:..::||.:.||:..:||||:....|:     |.| ||.|...|...|..
  Fly   353 AQGFSVKKVDAQKRIVTLNDGYEISYDECLIATGCAPKNLPMLRDAPPSV-LEKVMVYRTPDDFD 416

  Fly   310 AILASITPESRVVCLGSSFIALEAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDN- 373
            .:......:..:..:|:.||..|.|..|..       ..|||          .|.:|.|:|::|
  Fly   417 RLRKLAAEKRSITIVGNGFIGSELACSLAH-------YSREN----------NGGKVYQVFQENA 464

  Fly   374 ---KVV---------MRMESGIAEIVGN-------EDGKVSEVVLVDDTRLPCDLLILGTGSKLN 419
               ||:         .:||:....::.|       .|....::.|.:...|..|::::..|...|
  Fly   465 NMSKVLPNYLSRWTTAKMEAQGVCVIPNASIRSAVRDETNLKLELNNGMTLMSDVVVVCVGCTPN 529

  Fly   420 TQFLAKSGVKVNRN-GSVDVTDFLESNVPDVYVGGDIANAHIHGLAHDRVNIGHYQLAQYHGRVA 483
            |.....|.::|:|: |...|...||:. .::||.|| |:.....|. .|..:.|:..:...||:|
  Fly   530 TDLAGPSRLEVDRSLGGFVVNAELEAR-RNLYVAGD-ASCFFDPLL-GRRRVEHHDHSVVSGRLA 591

  Fly   484 AINMCGGVKKLEAVPFFFTLIFGKGIRYAGHGSYKDVIIDGSMEDFKFVAYFINEADTVTAV--A 546
            ..||.|..|..:....|::.: |..|.|.|.|     ::|.|:..   |..|...:::.|.|  .
  Fly   592 GENMTGAKKPYQHQSMFWSDL-GPEIGYEGIG-----LVDSSLPT---VGVFALPSESATRVDQL 647

  Fly   547 SCGRDPIVAQFAELISQGKCLGRGQIEDPAT 577
            |...|..|.:.:...||......|..:|..|
  Fly   648 SESSDSDVPETSTSSSQSSKSDAGASQDGVT 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	79/335 (24%)
		Pyr_redox	320..402	CDD:278498	21/101 (21%)
		Reductase_C	505..577	CDD:291425	18/73 (25%)
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	78/335 (23%)
		Pyr_redox	427..512	CDD:278498	21/101 (21%)
		AIF_C	591..720	CDD:291391	25/97 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43557
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840