DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4199 and Dld

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_955417.1	Gene:	Dld / 298942	RGDID:	735073	Length:	509	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	80/389 - (20%)
Similarity:	150/389 - (38%)	Gaps:	101/389 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 KPDDQRVFIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKI----SKAM-------- 227
            :|.|..| .|:|.||.|.||.....|.||  :.:.:.:.:.|....:.:    |||:
  Rat    38 QPIDADV-TVIGSGPGGYVAAIKAAQLGF--KTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99

  Fly   228 ----------NLEIEQLRFRDEEFYKEYDI---ELWQGVAAEKLDTAQKELHCSNGY-------- 271
                      .:||.::|...|:..::...   .|..|:|  .|....|.:|. ||:
  Rat   100 LAHGKDFASRGIEIPEVRLNLEKMMEQKRSAVKALTGGIA--HLFKQNKVVHV-NGFGKITGKNQ 161

  Fly   272 -----------VVKYDKIYLATGCSAFRPPIPGVNLENVRTVRELADTKAILASITPESRVVCLG 325
                       |:....|.:|||...  .|.||:.::....|   :.|.|:.....|| ::|.:|
  Rat   162 VTATTADGSTQVIGTKNILIATGSEV--TPFPGITIDEDTIV---SSTGALSLKKVPE-KLVVIG 220

  Fly   326 SSFIALEAAA------GLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIA 384
            :..|.:|..:      ..|:.|:.:..||...:.:      ||.:...::.:......::.:.:.
  Rat   221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDM------EISKNFQRILQKQGFKFKLNTKVT 279

  Fly   385 EIVGNEDGKV-----------SEVVLVDDTRLPCDLLILGTGSKLNTQFLA--KSGVKVNRNGSV 436
            ......|||:           :||:       .||:|::..|.:..||.|.  :.|::::..|.:
  Rat   280 GATKKSDGKIDVSVEAASGGKAEVI-------TCDVLLVCIGRRPFTQNLGLEELGIELDPKGRI 337

  Fly   437 DVTDFLESNVPDVYVGGDIANAHIHGLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLE--AVP 498
            .|....::.:|:::..||:....:  |||.         |:..|.:....|.||...::  .||
  Rat   338 PVNTRFQTKIPNIFAIGDVVAGPM--LAHK---------AEDEGIICVEGMAGGAVHIDYNCVP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	68/344 (20%)
		Pyr_redox	320..402	CDD:278498	15/98 (15%)
		Reductase_C	505..577	CDD:291425
Dld	NP_955417.1	lipoamide_DH	43..508	CDD:273568	78/384 (20%)
		NADB_Rossmann	45..222	CDD:304358	41/187 (22%)
		Pyr_redox	215..288	CDD:278498	11/78 (14%)
		Pyr_redox_dim	390..496	CDD:280934	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910