DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and Txnrd2

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_038739.2	Gene:	Txnrd2 / 26462	MGIID:	1347023	Length:	527	Species:	Mus musculus

Alignment Length:	347	Identity:	69/347 - (19%)
Similarity:	125/347 - (36%)	Gaps:	102/347 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DKIYLATGCSAFRPPIP---------GVNLENVRTVRELADTKAILASITPESRVVCLGSSFIAL 331
            :.|.:|||   .||..|         |:..:::..::|           :| .:.:.:|:|::||
Mouse   185 EHIVIATG---GRPRYPTQVKGALEYGITSDDIFWLKE-----------SP-GKTLVVGASYVAL 234

  Fly   332 EAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKV----------VMRMESGIAEI 386
            | .||.::.:...|.|...::||: .|..::...|.:..|.:..          :.::.:...::
Mouse   235 E-CAGFLTGIGLDTTVMMRSIPLR-GFDQQMSSLVTEHMESHGTQFLKGCVPSHIKKLPTNQLQV 297

  Fly   387 V------GNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRNGSVDVTDFLE-S 444
            .      |.||....:.||....|:|          :..|..|.|:|:..|......:.|..| :
Mouse   298 TWEDHASGKEDTGTFDTVLWAIGRVP----------ETRTLNLEKAGISTNPKNQKIIVDAQEAT 352

  Fly   445 NVPDVYVGGDIANAHIHGLAHDRVNIGHYQLAQYHGRVAAI----NM-----------CGGVKKL 494
            :||.:|..||:|..... |....:..|.....:..|:.:.:    |:           |.|:.:.
Mouse   353 SVPHIYAIGDVAEGRPE-LTPTAIKAGKLLAQRLFGKSSTLMDYSNVPTTVFTPLEYGCVGLSEE 416

  Fly   495 EAVPFFFTLIFGKGIRYAGHGSYKDVII-----DGSMEDFKFVAYFINEADTVTAVASCGRDP-- 552
            |||     .:.|:......|..||.:..     |.|....|.|               |.|:|
Mouse   417 EAV-----ALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMV---------------CMREPPQ 461

  Fly   553 ------IVAQFAELISQGKCLG 568
                  .:...|..::||..||
Mouse   462 LVLGLHFLGPNAGEVTQGFALG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560
		Pyr_redox_2	183..465	CDD:285266	45/214 (21%)
		Pyr_redox	320..402	CDD:278498	19/97 (20%)
		Reductase_C	505..577	CDD:291425	16/77 (21%)
Txnrd2	NP_038739.2	TGR	43..527	CDD:273624	69/347 (20%)
		NADB_Rossmann	43..>70	CDD:304358
		Pyr_redox	223..289	CDD:278498	14/67 (21%)
		Pyr_redox_dim	399..508	CDD:280934	21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910