DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4199 and dld1

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_593496.1	Gene:	dld1 / 2543269	PomBaseID:	SPAC1002.09c	Length:	511	Species:	Schizosaccharomyces pombe

Alignment Length:	480	Identity:	96/480 - (20%)
Similarity:	172/480 - (35%)	Gaps:	107/480 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 CR--VTDLKENEMKQVDFDEDTRVLLVKQNDR----LLAVGAKCTHYGAPLQTGALGLGRV---- 115
            ||  .|.|:.:|.:....:...|:...|.:..    |..:|.....|.|.::...|||..:
pombe    12 CRFKFTCLQVSECRPAQIEISKRLYSAKASGNGEYDLCVIGGGPGGYVAAIRGAQLGLKTICVEK 76

  Fly   116 RCPWHGACFNLENGDIEDFPGLDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLKNMVRRKPDDQR 180
            |....|.|.|:                        |.:..:|    |:||..:.:.|  |.|.:|
pombe    77 RGTLGGTCLNV------------------------GCIPSKA----LLNNSHIYHTV--KHDTKR 111

  Fly   181 VFIVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDEEFYKEY 245
            ..|.|.|     |:|                       :..::.||.:..::.|....|..:|:.
pombe   112 RGIDVSG-----VSV-----------------------NLSQMMKAKDDSVKSLTSGIEYLFKKN 148

  Fly   246 DIELWQGVAA--EKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTVRELADT 308
            .:|..:|..:  :....:.|.:..:....:|.....:|||...  .|.|||.::..:.|   :.|
pombe   149 KVEYAKGTGSFIDPQTLSVKGIDGAADQTIKAKNFIIATGSEV--KPFPGVTIDEKKIV---SST 208

  Fly   309 KAILASITPESRVVCLGSSFIALEAAAGLVSKVQSVTVVGRENVP-LKAAFGAEIGQRVLQLFED 372
            .|:..|..|:...| ||...|.||..:........||||  |.:| :.....|:|.:.:.::...
pombe   209 GALSLSEVPKKMTV-LGGGIIGLEMGSVWSRLGAEVTVV--EFLPAVGGPMDADISKALSRIISK 270

  Fly   373 NKVVMRMESGIAEIVGNEDGKVSEVVLVDDTR---LPCDLLILGTGSKLNTQFLA--KSGVKVNR 432
            ..:..:..:.:.....|.|....|:..:.:.:   ...|:|::..|....|:.|.  |.|:.:::
pombe   271 QGIKFKTSTKLLSAKVNGDSVEVEIENMKNNKRETYQTDVLLVAIGRVPYTEGLGLDKLGISMDK 335

  Fly   433 NGSVDVTDFLESNVPDVYVGGDIA-------NAHIHGLA--------HDRVNIGHYQLAQY-HGR 481
            :..|.:.....:|:|.:.|.||..       .|...|:|        ...||........| |..
pombe   336 SNRVIMDSEYRTNIPHIRVIGDATLGPMLAHKAEDEGIAAVEYIAKGQGHVNYNCIPAVMYTHPE 400

  Fly   482 VAAINMC------GGVK-KLEAVPF 499
            ||.:.:.      .|:| ::...||
pombe   401 VAWVGITEQKAKESGIKYRIGTFPF 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	19/102 (19%)
		Pyr_redox_2	183..465	CDD:285266	59/304 (19%)
		Pyr_redox	320..402	CDD:278498	17/82 (21%)
		Reductase_C	505..577	CDD:291425
dld1	NP_593496.1	PRK06327	45..511	CDD:235779	89/447 (20%)
		NAD_binding_8	50..>84	CDD:290186	8/33 (24%)
		Pyr_redox	219..297	CDD:278498	17/80 (21%)
		Pyr_redox_dim	392..498	CDD:280934	8/34 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910