Protein Alignment CG4199 and AIFM3

DIOPT Version :9

• Sequence 1: NP_001188537.1
• Gene: CG4199 / 31174
• FlyBaseID: FBgn0025628
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_001373743.1
• Gene: AIFM3 / 150209
• HGNCID: 26398
• Length: 605
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 215/587 - (36%)
• Similarity: 332/587 - (56%)
• Gaps: 33/587 - (5%)

  Fly     8 EYKTTGSTPKKEK-------STGGAVGSYQSKCSNQSPSTTMSTEE--------SSPDSEYTSAV 57
            |.|.....|:||:       |..|:..:||    ....:....|||        .||.....:||
Human    12 ELKIEVVLPEKERGKEELSASGKGSPRAYQ----GNGTARHFHTEERLSTPHPYPSPQDCVEAAV 72

  Fly    58 PVDCRVTDLKENEMKQVDFDEDTRVLLVKQNDRLLAVGAKCTHYGAPLQTGALGLGRVRCPWHGA 122
               |.|.||:..:|::|:.... :|||||.|....|:|.||.||||||..|.|..||||||||||
Human    73 ---CHVKDLENGQMREVELGWG-KVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGA 133

  Fly   123 CFNLENGDIEDFPGLDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLKNMVR-RKP----DDQRVF 182
            |||:..||:|||||||||..::|::..| :|.:||.:..|...:|.|.|.: ..|    ......
Human   134 CFNISTGDLEDFPGLDSLHKFQVKIEKE-KVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNV 197

  Fly   183 IVVGGGPSGAVAVETIRQEGFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDEEFYKEYDI 247
            ::||.|.:|.|..||:|||||:.|::....:.:|||||.|:||:::.:.|||..|.:||::.|.|
Human   198 LIVGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGI 262

  Fly   248 ELWQGVAAEKLDTAQKELHCSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTVRELADTKAIL 312
            |:........:|...|::...:|:.::|.|:.||.|.|.......|..:|||.|:|...|...::
Human   263 EVLTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVV 327

  Fly   313 ASITPESRVVCLGSSFIALEAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVM 377
             .:.....||.:|:.|:.:|.||.|..|..||:||..|..|.:...|..:|:.::::||:|:|..
Human   328 -RLARGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKF 391

  Fly   378 RMESGIAEIVGNEDGKVSEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRNGSVDVTDFL 442
            .|::.::|:.|.| ||:.||||.....:..|:.::|.|:...|.||.:||:.::..|.:.|...:
Human   392 YMQTEVSELRGQE-GKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMM 455

  Fly   443 ESNVPDVYVGGDIANAHIHGLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLEAVPFFFTLIFGK 507
            ::|||.|:..||.....:....:.:|||.|:|:|...|||||.||.....::..||:.:|.:|||
Human   456 QTNVPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGK 520

  Fly   508 GIRYAGHG-SYKDVIIDGSMEDFKFVAYFINEADTVTAVASCGRDPIVAQFAELISQGKCLGRGQ 571
            .:||||:| .:.||||.|.:|:.||||:: .:.|.|.||||...||||::.||:::.|:.:.:.:
Human   521 SLRYAGYGEGFDDVIIQGDLEELKFVAFY-TKGDEVIAVASMNYDPIVSKVAEVLASGRAIRKRE 584

  Fly   572 IE 573
            :|
Human   585 VE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	50/94 (53%)
		Pyr_redox_2	183..465	CDD:285266	93/281 (33%)
		Pyr_redox	320..402	CDD:278498	31/81 (38%)
		Reductase_C	505..577	CDD:291425	32/70 (46%)
AIFM3	NP_001373743.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..45		6/26 (23%)
		Rieske_AIFL_N	70..164	CDD:239560	52/98 (53%)
		Pyr_redox_2	195..493	CDD:400379	99/299 (33%)
		Reductase_C	512..>562	CDD:405449	25/50 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2167
Isobase	1	0.950	-	0	Normalized mean entropy	S3886
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm40528
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820