DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and AgaP_AGAP003904

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	XP_003436656.1	Gene:	AgaP_AGAP003904 / 1269496	VectorBaseID:	AGAP003904	Length:	566	Species:	Anopheles gambiae

Alignment Length:	561	Identity:	295/561 - (52%)
Similarity:	375/561 - (66%)	Gaps:	27/561 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KEYKTTGSTPKKEKSTGGAVGSYQSKCSNQSPSTTMSTEESSPDSEYTSAVPVDCRVTDLKENEM 71
            |..|.|.:|   ..|.|||.|::                    |.::..||.  |:..::.||:|
Mosquito    18 KASKVTAAT---STSNGGAAGTH--------------------DDDFIEAVV--CQELEIGENQM 57

  Fly    72 KQVDFDEDTRVLLVKQNDRLLAVGAKCTHYGAPLQTGALGLGRVRCPWHGACFNLENGDIEDFPG 136
            |||:..|. :||||:||.:|.|:|.||:||||.|.|||||.|||||||||||||:|.||||||||
Mosquito    58 KQVELGEG-KVLLVRQNGKLSAIGNKCSHYGAMLVTGALGEGRVRCPWHGACFNVETGDIEDFPG 121

  Fly   137 LDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLKNMVRRKPDDQRVFIVVGGGPSGAVAVETIRQE 201
            :||||||||.||..|:|.:||||::|..|||.:.|.:|...|.|.::|:|||||||...||:|||
Mosquito   122 MDSLPCYRVTVGEAGEVKVRAKRTELATNKRTRVMAKRAAQDARTYVVIGGGPSGATCAETLRQE 186

  Fly   202 GFTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDEEFYKEYDIELWQGVAAEKLDTAQKELH 266
            |||||::.:.:|..|||||||:||.|:|.:|::..|.::||.|.|||:..|.|..|||.|..||.
Mosquito   187 GFTGRIVMINKEPCLPYDRVKVSKTMDLNLEKVLLRTQQFYDENDIEVMLGTAVTKLDGATHELT 251

  Fly   267 CSNGYVVKYDKIYLATGCSAFRPPIPGVNLENVRTVRELADTKAILASITPESRVVCLGSSFIAL 331
            ..|||.::|||.|:|||.:..||||.|.:|.||..:|..||.|.:...:.||.|||.||:|||.|
Mosquito   252 LDNGYKIRYDKAYIATGSNPRRPPIEGASLGNVCVLRTAADAKQVNEQLAPEKRVVILGTSFIGL 316

  Fly   332 EAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIAEIVGNEDGKVSE 396
            ||||..|:||..|||:||..||||.:||..|||||::|||:..|...|.|||...:|.| |.|.:
Mosquito   317 EAAAYCVNKVAKVTVIGRGAVPLKESFGDAIGQRVMELFEEKGVQFVMNSGIRRCIGAE-GAVQQ 380

  Fly   397 VVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRNGSVDVTDFLESNVPDVYVGGDIANAHIH 461
            |.|.|.|.|..|:.|.|.||.|.|:||..||:.:|||||::...:||||:..||||||||||.:|
Mosquito   381 VELTDGTLLDADICIFGIGSTLYTEFLQGSGISLNRNGSINTDQYLESNLEGVYVGGDIANAPVH 445

  Fly   462 GLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLEAVPFFFTLIFGKGIRYAGHGSYKDVIIDGSM 526
            .....:..||||.||||||||||:||.|....|:|||||:|::|||..||.|:|...:|||||.:
Mosquito   446 SNDGQQATIGHYPLAQYHGRVAALNMIGKATPLKAVPFFWTVLFGKSFRYCGYGQPDEVIIDGDL 510

  Fly   527 EDFKFVAYFINEADTVTAVASCGRDPIVAQFAELISQGKCL 567
            ...||||::|.:...|..::||.|||:||||||..||||.|
Mosquito   511 AALKFVAFYIGKGGRVIGMSSCQRDPVVAQFAEYSSQGKVL 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	62/94 (66%)
		Pyr_redox_2	183..465	CDD:285266	150/281 (53%)
		Pyr_redox	320..402	CDD:278498	46/81 (57%)
		Reductase_C	505..577	CDD:291425	34/63 (54%)
AgaP_AGAP003904	XP_003436656.1	Rieske_AIFL_N	44..138	CDD:239560	64/96 (67%)
		Pyr_redox_2	167..464	CDD:285266	158/297 (53%)
		NADB_Rossmann	168..>200	CDD:304358	19/31 (61%)
		Pyr_redox	305..386	CDD:278498	46/81 (57%)
		Reductase_C	484..>534	CDD:291425	22/49 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	310	1.000	Domainoid score	I3488
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I2599
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm49757
Panther	1	1.100	-	-	LDO	PTHR43557
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1666
TreeFam	0	0.000	Not matched by this tool.
	10	10.080