Protein Alignment CG4199 and TXNRD3

DIOPT Version :9

• Sequence 1: NP_001188537.1
• Gene: CG4199 / 31174
• FlyBaseID: FBgn0025628
• Length: 593
• Species: Drosophila melanogaster
• Sequence 2: NP_443115.1
• Gene: TXNRD3 / 114112
• HGNCID: 20667
• Length: 643
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 106/515 - (20%)
• Similarity: 176/515 - (34%)
• Gaps: 173/515 - (33%)

  Fly    47 SSPDSEYTSAVPVDCRVTDLKENEMKQ--VDFDEDTRVLLVKQNDRLLAVGAKCTHYGAPLQT-G 108
            |.|......:.|...|.::.:| |:::  |...|.:||::..:        :.|.|.....:. .
Human    32 SPPGRRARLSSPGPSRSSEARE-ELRRHLVGLIERSRVVIFSK--------SYCPHSTRVKELFS 87

  Fly   109 ALGLGRVRCPWHGACFNLENGDIEDFPGLDSLPCYRVEVGNEGQVMLRAKRSDLVNNKRLKNMVR 173
            :||:         .|..||...::|              |...|.:|    |::.|.|.:.|:..
Human    88 SLGV---------ECNVLELDQVDD--------------GARVQEVL----SEITNQKTVPNIFV 125

  Fly   174 RKPD----DQRV---------------------FIVVGGGPSGAVAVETIRQEGFTGRLIFV--- 210
            .|..    ||..                     .|::|||..|   :...::....|:.:.|
Human   126 NKVHVGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGG---LSCAKEAAILGKKVMVLDF 187

  Fly   211 --------------------CREDYLPYDRVKISKAMNLEIEQLRFRDEEFYKEYDIEL---WQG 252
                                |....|.:....:.:|:        ....:|..||:.::   |:.
Human   188 VVPSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQAL--------CDSRKFGWEYNQQVRHNWET 244

  Fly   253 VA------------AEKLDTAQKELHCSNGY--VVKYDKI-----------------YLATGCSA 286
            :.            ..:|...:|.:...|.|  .|::.||                 .:|||
Human   245 MTKAIQNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATG--- 306

  Fly   287 FRPPIPGVNLENVRTVRELADTKAILASITP--ESRVVCLGSSFIALEAAAGLVSKVQSVTVVGR 349
            .||...|:..:     :|...|...|.|: |  ..:.:.:|:|::|||.|..|......|||:.|
Human   307 ERPRYLGIQGD-----KEYCITSDDLFSL-PYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVR 365

  Fly   350 ENVPLKAAFGAEIGQRVLQLFEDNKV----------VMRMESGIAEIVGNEDGKVSEVVLVDDTR 404
            .  .|...|..|:.::|....|.:.|          |.::|.|       ..||:.  ||...|.
Human   366 S--ILLRGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKG-------SPGKLK--VLAKSTE 419

  Fly   405 --------LPCDLLILGTGSKLNTQFLAKSGVKVN-RNGSVDVTDFLESNVPDVYVGGDI 455
                    ....||.:|..|......|.|.|||:| ::|.:.|.|..::|||.||..|||
Human   420 GTETIEGVYNTVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDI 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	17/97 (18%)
		Pyr_redox_2	183..465	CDD:285266	78/351 (22%)
		Pyr_redox	320..402	CDD:278498	24/91 (26%)
		Reductase_C	505..577	CDD:291425
TXNRD3	NP_443115.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		4/20 (20%)
		GRX_GRXh_1_2_like	67..148	CDD:239511	20/115 (17%)
		TGR	155..643	CDD:273624	78/356 (22%)
		Pyr_redox	336..412	CDD:278498	22/84 (26%)
		Pyr_redox_dim	515..625	CDD:280934

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910