DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4199 and aifm3

DIOPT Version :9

Sequence 1:	NP_001188537.1	Gene:	CG4199 / 31174	FlyBaseID:	FBgn0025628	Length:	593	Species:	Drosophila melanogaster
Sequence 2:	NP_001121885.1	Gene:	aifm3 / 100150876	-ID:	-	Length:	599	Species:	Danio rerio

Alignment Length:	570	Identity:	212/570 - (37%)
Similarity:	338/570 - (59%)	Gaps:	28/570 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 STPKKEKSTGGAVGSYQSKCSNQSPSTTMSTEESSPDSEYTSAVPVDCRVTDLKENEMKQVDFDE 78
            ::|..|....|::|    .||::. |.|:..:..:.|....|.    |.:.||:..:|::||...
Zfish    35 ASPFSECRPNGSLG----HCSDED-SMTLRPQRKNRDYIEASV----CHIKDLENGQMREVDLGA 90

  Fly    79 DTRVLLVKQNDRLLAVGAKCTHYGAPLQTGALGLGRVRCPWHGACFNLENGDIEDFPGLDSLPCY 143
            . |.||:|::....|:|.||.||||||..|.|..|.|||||||||||:..|||||||||||||.:
Zfish    91 G-RALLIKEHGEFFAMGHKCPHYGAPLVKGVLSKGHVRCPWHGACFNIATGDIEDFPGLDSLPTF 154

  Fly   144 RVEVGNEGQVMLRAKRSDLVNNKRLKNM------VRRKPDDQRVFIVVGGGPSGAVAVETIRQEG 202
            :|.|..| :|::||.:..|...:|.|.|      :........| :::|.||:|.|..||:||||
Zfish   155 QVRVEKE-KVIIRANKQALQTQRRSKVMSKCSAVINSSTGFSHV-LIIGSGPAGLVCAETLRQEG 217

  Fly   203 FTGRLIFVCREDYLPYDRVKISKAMNLEIEQLRFRDEEFYKEYDIELWQGVAAEKLDTAQKELHC 267
            ||.|::....:.:|||||.|:||::....|||:.|..:|::.:|||:........:|.....:..
Zfish   218 FTDRIVICTTDKHLPYDRPKLSKSLESTAEQLQLRSSDFFQMHDIEVLLEKEVVSVDVKTHTVTF 282

  Fly   268 SNGYVVKYDKIYLATGCSAFRP-PI--PGVNLENVRTVRELADTKAILASITPESRVVCLGSSFI 329
            .:|:.::|.|:::|||.   || |:  .|.::.||..:|...|..:|: ::......|.:|:|||
Zfish   283 RDGFKMEYRKLFIATGS---RPKPLSYKGKDVGNVFHLRTPEDANSIV-TLASSKNAVIIGTSFI 343

  Fly   330 ALEAAAGLVSKVQSVTVVGRENVPLKAAFGAEIGQRVLQLFEDNKVVMRMESGIAEIVGNEDGKV 394
            .:|.||.|..|..||:|:|.|.||.:.|.|.::|:.:::|||.|:|...|.:.:.|:.|: :|::
Zfish   344 GMEVAAALTDKAHSVSVIGIEAVPFRKALGEKVGKALMKLFESNRVKFYMLNEVWEMRGH-NGQL 407

  Fly   395 SEVVLVDDTRLPCDLLILGTGSKLNTQFLAKSGVKVNRNGSVDVTDFLESNVPDVYVGGDIANAH 459
            .||||.....|..|:.::|.||...|.||.:|||.::..|.:.|...:::|:..|:.|||:....
Zfish   408 KEVVLKSGKVLRADVCVIGIGSSPATAFLKQSGVHIDSKGFIPVNKTMQTNIDGVFAGGDVVTFP 472

  Fly   460 IHGLAHDRVNIGHYQLAQYHGRVAAINMCGGVKKLEAVPFFFTLIFGKGIRYAGHG-SYKDVIID 523
            :...::.:|||.|:|:|..|||:||:.:.|....::.||:|:|.:|||.|||||:| .:.||:|.
Zfish   473 LGLRSNKKVNIPHWQMAHVHGRLAALGIMGKASDIKTVPYFWTAMFGKSIRYAGYGDGFDDVVIQ 537

  Fly   524 GSMEDFKFVAYFINEADTVTAVASCGRDPIVAQFAELISQGKCLGRGQIE 573
            |.:::.||||:: .:::.|.||||...||||::.||:...||.:.:..:|
Zfish   538 GDLDELKFVAFY-TKSEEVVAVASMNYDPIVSRVAEVFGSGKTIRKRDVE 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4199	NP_001188537.1	Rieske_AIFL_N	59..154	CDD:239560	50/94 (53%)
		Pyr_redox_2	183..465	CDD:285266	97/284 (34%)
		Pyr_redox	320..402	CDD:278498	33/81 (41%)
		Reductase_C	505..577	CDD:291425	31/70 (44%)
aifm3	NP_001121885.1	Rieske_AIFL_N	70..164	CDD:239560	51/99 (52%)
		Pyr_redox_2	196..493	CDD:285266	104/302 (34%)
		NAD_binding_8	199..>218	CDD:290186	10/18 (56%)
		Pyr_redox	334..415	CDD:278498	33/81 (41%)
		Reductase_C	512..>562	CDD:291425	24/50 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2498
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1909
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		mtm6441
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870