Protein Alignment Sik2 and NUAK1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_055655.1
• Gene: NUAK1 / 9891
• HGNCID: 14311
• Length: 661
• Species: Homo sapiens
• Alignment Length: 757
• Identity: 227/757 - (29%)
• Similarity: 319/757 - (42%)
• Gaps: 220/757 - (29%)

  Fly   106 GGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRV----------GFYDIERTIGKGNFAVVKLARH 160
            |...|| ||..:..||..     .|:.::|..|          ..|:::.|:|||.:..||.|..
Human    16 GLGAPG-SPREAVAGATA-----ALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATE 74

  Fly   161 RITKNEVAIKIIDKSQL-DQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGE 224
            |.:...||||.|.|.:: |:.::..:.||:|||..|.|||||.:|:|.|.|:.|.|:.||||:||
Human    75 RFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGE 139

  Fly   225 IFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFK 289
            ::|||::..|:||...|..|.||:|||.||||.|:||||||.||:|||.|.||||||||.||.::
Human   140 LYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQ 204

  Fly   290 PGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGR 354
            ..:.|.|:||||.||:||:..|:.|.|||:|.|:|||:||.||.|.:||||...::|..::.||.
Human   205 KDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGE 269

  Fly   355 FRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM----------CPEL--LEHVLIAKYNL 407
            :|.| ...|:...|||.||::.|.||.||:.|..|.|:          |..|  .|..|:|:...
Human   270 YREP-TQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIID 333

  Fly   408 GAERQTSVEPSEDILRIMAEYVGIGSDKTRASLK---KNTYDHVAAIYLLLQDRVSHKKEQSNGL 469
            ...|.|                |:.:| |.|.:|   |.|...|    :|.:.|...|.::.|..
Human   334 WHHRST----------------GLQAD-TEAKMKGLAKPTTSEV----MLERQRSLKKSKKENDF 377

  Fly   470 ---GASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSI-------------LAKDQCHK 518
               |..|:..|.|.    .||:......:::|..:.::.||..|             :.:|.|..
Human   378 AQSGQDAVPESPSK----LSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRT 438

  Fly   519 --------------RLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTG 569
                          :||..|:..|.::    |..........|||:.          ...|..:.
Human   439 GVLLPSSPEAEVPGKLSPKQSATMPKK----GILKKTQQRESGYYSS----------PERSESSE 489

  Fly   570 YLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDN 634
            .|:..  :|..|.||            ||:|.:    .:||..||||
Human   490 LLDSN--DVMGSSIP------------SPSPPD----PARVTSHSLS------------------ 518

  Fly   635 NPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDP 699
                    ||.                                     :.:|:.|:..:.|..||
Human   519 --------CRR-------------------------------------KGILKHSSKYSAGTMDP 538

  Fly   700 -------PKAES-SVGGVPPPA---STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFD--- 750
                   |..|| |..|||...   |.:..||....:|                :.||.|||
Human   539 ALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDS----------------VLSSDSFDLLD 587

  Fly   751 --SKANLGQSFRYKMSAE---ASKLFQTLQESPLPVEQRTKR 787
              ......|..|..:|||   ..:.|:.||..|.|  |..||
Human   588 LQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRP--QYLKR 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	126/252 (50%)
		UBA_SIK	418..458	CDD:270523	9/42 (21%)
NUAK1	NP_055655.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		4/8 (50%)
		STKc_NUAK	53..306	CDD:270975	126/253 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..421		20/83 (24%)
		GILK motif	399..402		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..570		38/222 (17%)