Protein Alignment Sik2 and MELK

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_055606.1
• Gene: MELK / 9833
• HGNCID: 16870
• Length: 651
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 166/534 - (31%)
• Similarity: 257/534 - (48%)
• Gaps: 90/534 - (16%)

  Fly   128 DLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIM 192
            :|||        :|::..|||.|.||.||||.|.:|...|||||:||:.|. ::|.::..|:|.:
Human     6 ELLK--------YYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG-SDLPRIKTEIEAL 61

  Fly   193 KRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKK 257
            |.|:|.||.:||.|:||.|.|::|.||...||:||||....|:||...|..|.||:|||.|.|.:
Human    62 KNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ 126

  Fly   258 GIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGE--LLATWCGSPPYAAPEVFEGKQYTGPEID 320
            |..|||||.||||.|....:|:.|||.....|..:  .|.|.|||..|||||:.:||.|.|.|.|
Human   127 GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEAD 191

  Fly   321 IWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQ 385
            :||:|::||||:||.||||...:.:|..:::.|::.:|.::|.....|:::||.::|.:|.::..
Human   192 VWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKN 256

  Fly   386 IKRHRWMCPELLEHVLIAKYNLGAERQTS---VEPSEDILRIMAEYVGIGSDKTRASLKKNTYDH 447
            :..|.|         ::..||...|.|:.   :...:|.:..::.:...........:....|||
Human   257 LLNHPW---------IMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDH 312

  Fly   448 VAAIYLLLQDRVSHKKE-----QSNGLG-ASA------------LASSTSASRMIYSSRNDHQ-- 492
            :.|.||||..:.:..|.     .|...| |||            |...|::.:...:...|:.
Human   313 LTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWC 377

  Fly   493 --------PTQQQSQ-----QQSKTISTSSI---LAKDQCHKRLSRH-----QTVLMSE------ 530
                    .|.:.||     .:|..:.:.|:   |.:...:|..::.     ::.:.:|
Human   378 EDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFP 442

  Fly   531 -------RNAHAG---ATP---TVPDPGPGYYAKYGPLQLPLPLTGHSHL-TGYLNG----GGVE 577
                   :|.|..   .||   |.|........|..|:::|:..||...| ||.::.    ..||
Human   443 EPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVE 507

  Fly   578 VDASGIPLPMRYTP 591
            :|.:  ...|..||
Human   508 LDLN--QAHMEETP 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	112/253 (44%)
		UBA_SIK	418..458	CDD:270523	9/39 (23%)
MELK	NP_055606.1	STKc_MELK	7..263	CDD:270980	116/273 (42%)
		UBA_MELK	281..332	CDD:270526	10/50 (20%)
		UBA-like	282..321		8/38 (21%)
		Autoinhibitory region	326..651		37/196 (19%)
		MELK_C	555..649	CDD:213383