Protein Alignment Sik2 and BRSK2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_054189097.1
• Gene: BRSK2 / 9024
• HGNCID: 11405
• Length: 895
• Species: Homo sapiens
• Alignment Length: 996
• Identity: 253/996 - (25%)
• Similarity: 387/996 - (38%)
• Gaps: 263/996 - (26%)

  Fly   107 GSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKI 171
            |...|.:...||..|....|:.|       |.|              :|||..|.:|..:|||||
Human    21 GEPAGDTGFLSAPAAPKAEGRAL-------RAG--------------LVKLGVHCVTCQKVAIKI 64

  Fly   172 IDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMS 236
            :::.:|.::.|.||.||:.|:|.::|||::||:.|.|.|..:|:|.|:.|.||:|||:.|.||::
Human    65 VNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLT 129

  Fly   237 ESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSP 301
            ...||..|.|||||:::||...|.|||||.||||||...||:|||||.::......||.|.||||
Human   130 PKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSP 194

  Fly   302 PYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECE 366
            .||.|||..|::|.|.:.|:||.||:|:.|:.||||||...|:.|.::|..|.|.:|.|:..:|:
Human   195 HYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 259

  Fly   367 HLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGI 431
            .|:|.|:.::..||.|::.|::|.|.              :|.:.:.  ||.:.|.|    .|.|
Human   260 SLLRGMIEVDAARRLTLEHIQKHIWY--------------IGGKNEP--EPEQPIPR----KVQI 304

  Fly   432 GSDKTRASLKKNTYDHVAAI------YLLLQDRVSHKKEQSNGLGASALASSTSASRMIY---SS 487
            .|..:...:..:..|.:.::      ..||||.:|.::.|               .:|||   ..
Human   305 RSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQ---------------EKMIYFLLLD 354

  Fly   488 RNDHQPTQQQSQQQSKTISTSSILAKDQCHKR-----LSRH-----QTVLMSERNAHAGATPTVP 542
            |.:..|:|:......:.       ..|...||     |:||     :...|...:...|.:| ||
Human   355 RKERYPSQEDEDLPPRN-------EIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSP-VP 411

  Fly   543 DPGPGYYAKYGPLQLPL----------PLTGHSHLTGYLNG--GGVEVDASGIPLPMR------- 588
            .......|::|..:...          |.......:..::|  .|:.......|.|:|
Human   412 ARRAIEMAQHGQSKAMFSKSLDIAEAHPQFSKEDRSRSISGASSGLSTSPLSSPRPIRKLVLPPP 476

  Fly   589 -----YTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMM- 647
                 :...|.|.|..|..|.| :||.| |.|         |:..:|..|  |....|.|:..:
Human   477 PPEPPFVARPLATSTEPEACGS-ASRPG-HVL---------PLQAALRPD--PKTQTLPCKAKLT 528

  Fly   648 -------EAGGGPVGAVGVPLAS---KQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKA 702
                   ::...|......|.|:   .||...:....::.......|.::.:|.........|..
Human   529 DKPLQGTKSNPFPASTPARPPATGLCPQLAPPLGPPALRVPPRPPPAGIEPNTKSVPTIQVTPHP 593

  Fly   703 ESSVGGVPPPAST---TPTSSTAG---------PESGSAPCPGEINGKTIK-------------- 741
            ......:|.|..|   ||..|.||         |..|..|....:|  :||
Human   594 SPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSSPSVGGVPWRARLN--SIKNSFLGSPRFHRRKL 656

  Fly   742 -----------TMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPL---------------- 779
                       |..||.....|:..|.....:   :..::|..:::.||
Human   657 QVPTPEEMSNLTPESSPELAKKSWFGNFISLE---KEEQIFVVIKDKPLSSIKADIVHAFLSIPS 718

  Fly   780 ---PVEQRTKRRVHVGSTNG-----------------SGGDSGQETNDAKS------NGDSRSEK 818
               .|..:|..|....:|.|                 .||:: |:.|...|      :|.||..|
Human   719 LSHSVISQTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEA-QKENGIYSVTFTLLSGPSRRFK 782

  Fly   819 KVLAQGSSSTDEGCETDQG-----NDPGSASQESKGSN----GGGSGNANGGPTSHSSSDLTRLV 874
            :|:           ||.|.     :||.:|...|..:|    ..|..:..|.|.|:....:.:|.
Human   783 RVV-----------ETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLF 836

  Fly   875 GTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGS 939
            ....:||:.:..|..:..|:.|.|..||                   .:||....|...|:||
Human   837 SDEKNGQAAQAPSTPAKRSAHGPLGDSA-------------------AAGPGPGGDAEYPTGK-- 880

  Fly   940 LPSCMGSSSMLATPTPASASP 960
                  .::.:..||.....|
Human   881 ------DTAKMGPPTARREQP 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	111/251 (44%)
		UBA_SIK	418..458	CDD:270523	9/45 (20%)
BRSK2	XP_054189097.1	STKc_BRSK1_2	46..285	CDD:270983	112/252 (44%)
		UBA_BRSK	312..365	CDD:270525	13/67 (19%)