Protein Alignment Sik2 and FRK1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_015184.1
• Gene: FRK1 / 855962
• SGDID: S000006062
• Length: 865
• Species: Saccharomyces cerevisiae
• Alignment Length: 995
• Identity: 264/995 - (26%)
• Similarity: 387/995 - (38%)
• Gaps: 240/995 - (24%)

  Fly   139 GFYDIERTIGKGNFAVVKLARHRITKN----------EVAIKIIDKSQL--DQTNLQKVYREVEI 191
            |.|.:..|:|:|.|..|||...:...|          :||||:|.:..:  |.....|:|||:..
Yeast    39 GPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINA 103

  Fly   192 MKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHK 256
            :|.|.||:|:||.:|::....|.||.|||..||.:.||.|..|:.|..|...|.|:||.|.|.|.
Yeast   104 LKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIHS 168

  Fly   257 KGIVHRDLKAENLLLDLNMNIKIADFGFSNHF-KPGELLATWCGSPPYAAPE-VFEGKQYTGPEI 319
            ||:||||||.||||||.|.|:.|.||||.|.| ...||:.|.||||.||||| |...:.|...:.
Yeast   169 KGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKA 233

  Fly   320 DIWSLGVVLYVLVCGALPFD-------GSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEP 377
            ||||.||:||.::.|.||:|       ||.:..|.:.:.|...:.|.::......|:|||||.:|
Yeast   234 DIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRMLVSDP 298

  Fly   378 TRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKK 442
            .:|..:.|||:|.|:.|.              ....|:.|.|             .||
Yeast   299 KKRINLKQIKKHEWLKPH--------------SSFLSITPDE-------------WDK------- 329

  Fly   443 NTYDHVAAIYLLLQDRVSHKKEQSNGLGASALAS-STSASRMIYSSRNDHQPTQQQSQQQSKTIS 506
              .::..:::.|.:.|..:.....:....|:|.| |.....::..|.....|...| :.|:..|:
Yeast   330 --LNNTQSVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFPAPPQ-ESQNHIIT 391

  Fly   507 TSSILAKDQCHKRLS------RHQTVLMSERNAHAGATPTVPDPGPGYYAKY----GPLQLPLPL 561
            ..:.:|.||   |||      ||.    ...:|.:.|...|.:....|...:    .|:|.....
Yeast   392 RPASIASDQ---RLSPIRRSNRHN----RSNSAASVALQAVVNADREYVLSHEQSLSPVQNIRQT 449

  Fly   562 TGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPV 626
            ||:             :.||..|        |.|.||......:|.  :.|:::|.||      :
Yeast   450 TGN-------------MTASLSP--------PPAISPGDIIIETTP--IKRNTISGSS------I 485

  Fly   627 AISLSIDNNPSLANLRCREMMEAGGGPVGAVGVP--LASKQLHQTISEFIIKQSTEDCRALLQQS 689
            ..||..:::.::...:.:               |  :||.|.||     ..|..|::.   ||.:
Yeast   486 VPSLEEESSTTMQTSKIQ---------------PNNMASSQNHQ-----YNKNKTQNS---LQSA 527

  Fly   690 TAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSS-------SS 747
            ....       :..||....|.|.|..|.|.|..|.:.:.....|||.|...:.||       :|
Yeast   528 KNFY-------RTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEINEKAKSSASSQTLNQRDTS 585

  Fly   748 SFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQR----TKRRVHVGSTNGS------GGDSG 802
            .|||...|........|:       :::.||..:...    .|..|.:.|.:|.      ..|..
Yeast   586 PFDSTPYLALDTCITSSS-------SIESSPKLITHGQFSVAKPSVDLQSVSGDLIKYKRDADVV 643

  Fly   803 QETNDAKSNGDSRSEKKVLAQGSSSTDEGCET-----DQGNDPGSASQESKGSNGGGSGNANGGP 862
            ....|.|    .:.::|.|......:|..|:|     |:...|.|..|:.:|
Yeast   644 TRIYDEK----YKQKRKSLRYSGIFSDISCDTVTEESDELRPPESPLQQHEG------------- 691

  Fly   863 TSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRG-----SSKSNC 922
              ..|.|..:...|:..|           |.||.:...:|   .|.::.:|.|.     |:|...
Yeast   692 --QESIDKAKTEDTSEKG-----------SKSSNIAKATA---QKHVNNHLERSLNEAESTKKRF 740

  Fly   923 SGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPAS-ASPAGISSEHSSERSLY--GSHNSCIHMP 984
            |  :.|| ::..:.|.||.|.|.|.   ..|:|.| ..|....|..::.::.|  .|:....|
Yeast   741 S--FLSL-YSYDTSKSSLYSSMDSK---RKPSPPSQRRPKKDDSYQTNSKNHYITASNMQTSH-- 797

  Fly   985 GALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDK------RSPIHFREGRRAS-DGLVAQGLLS 1042
                        ..|...|.||...|  ..|...|      ||.|...|..:|| |...||....
Yeast   798 ------------QVSKDLPAPTMVQN--KCTLETKKAVRSNRSSIMVSEVNKASVDNKAAQSPEH 848

  Fly  1043 SGSLLGTSRVYGSYRYEQAK 1062
            |.:    .||.|.::....|
Yeast   849 STA----KRVLGFFKRRSMK 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	114/272 (42%)
		UBA_SIK	418..458	CDD:270523	4/39 (10%)
FRK1	NP_015184.1	Protein Kinases, catalytic domain	39..313	CDD:473864	115/273 (42%)