Protein Alignment Sik2 and PRR1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_012806.1
• Gene: PRR1 / 853744
• SGDID: S000001599
• Length: 518
• Species: Saccharomyces cerevisiae
• Alignment Length: 318
• Identity: 91/318 - (28%)
• Similarity: 138/318 - (43%)
• Gaps: 73/318 - (22%)

  Fly   145 RTIGKGNFAVVKLARHRITKN----EVAIKII----DKSQLDQTNLQKVY------------REV 189
            |.||.|||:.|.|.......|    :||:|.:    :.|.::|.|....|            ||:
Yeast   196 RPIGSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTREL 260

  Fly   190 EIMKRLKHPHIIKLYQVMETKNMIYIVSE----------------------YASQGEIFDYI-AK 231
            :::|.|.||.|:||..:   .|.|::.|:                      |...|::...: |:
Yeast   261 QVLKSLNHPCIVKLLGI---NNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMAR 322

  Fly   232 YGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLL-----DLN----------MN-IKIA 280
            .||:.....:..|.:::.||:|.|:..|:|||||.||:||     |:|          .| |::|
Yeast   323 NGRLEAWLIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELA 387

  Fly   281 DFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQS 345
            |||.....:..|:....|||..|.:||:..|..|.|...|.|:|||:||.|....||||.....|
Yeast   388 DFGLCKKIENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNAS 452

  Fly   346 LRDRVLS-----GRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLE 398
            .|.|..:     .||...::..|:.:..:.:.:|.....|      |..||...|:.|
Yeast   453 ARQRSRATSHRIARFDWRWYRLSDYKTNVGKQIVENTLTR------KNQRWSINEIYE 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	88/310 (28%)
		UBA_SIK	418..458	CDD:270523
PRR1	NP_012806.1	S_TKc	192..508	CDD:214567	91/318 (29%)