Protein Alignment Sik2 and PTK1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_012723.3
• Gene: PTK1 / 853635
• SGDID: S000001681
• Length: 662
• Species: Saccharomyces cerevisiae
• Alignment Length: 755
• Identity: 167/755 - (22%)
• Similarity: 262/755 - (34%)
• Gaps: 267/755 - (35%)

  Fly     9 AGENGSQAKSEESQPPEDQKKKQPQHERNEKQLDKPPENLPQNGKTEAKG---AEGACSHPPLDA 70
            :..:|::.|.:.|.||:       .|..:....:.....||.:.||..:.   |....|...|.:
Yeast    31 SSSHGNKLKKKASLPPD-------FHSTSTNDSESSSPKLPNSLKTSRRANSFAHTTNSKRSLSS 88

  Fly    71 LRSSVLLDAGAA-SPSIDAIVACKDALLAQKLFASG-------GGSTPGPSPTSSAVGAGGISGK 127
            ..:.:|..||:: |.|.....:.....|:...|:|.       |.|||..|.:|.:.
Yeast    89 ASTKILPPAGSSTSISRGNRHSSTSRNLSNSKFSSERLVYNPYGVSTPSTSLSSVST-------- 145

  Fly   128 DLLKLKEPMRVGFY----------------------------------------DIERTIGKGNF 152
               .:|:...:|||                                        |..:|||.|..
Yeast   146 ---SMKKDPDLGFYLHDGDSKIRMLPIPIVDPNEYLPDEMKEASIQLSDNFVFDDENKTIGWGGS 207

  Fly   153 AVVKLARHRITKNEV-AIKIIDK--SQLDQTNLQKVYREVEIMKRLK-HPHIIKLYQVMETKNMI 213
            ..|:..|.:..|.:| |:|.::.  ::..:...::..:|..|.|:|. |.||...:.:::....:
Yeast   208 CEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYKRCSKEFIIAKQLSHHVHITNTFLLVKVPTTV 272

  Fly   214 Y------IVSEYASQGEIFDYIAKYG----RMSESAARFKFWQIISAVEYCHKKGIVHRDLKAEN 268
            |      .|.|...: ::|..|.|.|    .::|....||  |:...|::||.:||.|||||.||
Yeast   273 YTTRGWGFVMELGLR-DLFAMIQKSGWRSVALAEKFCIFK--QVACGVKFCHDQGIAHRDLKPEN 334

  Fly   269 LLLDLNMNIKIADFGFSN--HFKPGEL------LATWCGSPPYAAPEV--FEGKQYTGPE----- 318
            :||..:...|:.|||.|:  |..|.:|      .|...||||||.|||  ::.|::...|
Yeast   335 VLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQQPY 399

  Fly   319 ----IDIWSLGVVLYVLVCGALPFDGSTLQS-------------------LRDRVL--SGRFR-- 356
                :|.:.||::|..||...:||    |:|                   |.||..  .|.:|
Yeast   400 DPRALDCYGLGIILMTLVNNVIPF----LESCSFDTGFRDYCDAYENFIRLHDRAFRNRGNYRPG 460

  Fly   357 -------IPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTS 414
                   ...|.:.....:..|:...|...|||||.:....|.              .|.|  |.
Yeast   461 PGMEYHLARNFKNGHASRVAWRLADPEAATRYTIDDLFEDPWF--------------QGIE--TC 509

  Fly   415 VEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTS 479
            |:.::       :||     ..:..:|..||::....::                 |:.:|::|.
Yeast   510 VDAND-------KYV-----CKKPIIKTTTYENPRGFHI-----------------ATDVAATTP 545

  Fly   480 ASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTV--- 541
            .|.....:|   .|.:.                               |.:..||...|.||
Yeast   546 TSNPFLKNR---VPIRS-------------------------------MVDIAAHPSPTATVLAS 576

  Fly   542 -PDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLP----------TA 595
             |.|.|             |.|              .|.|..: ..:|.||.|          ..
Yeast   577 SPPPPP-------------PAT--------------HVPAEAL-FTLRETPPPQLATLTLSEEPP 613

  Fly   596 ASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNN 635
            |:||||..|:.|:||..||       .||.|...|:|.|:
Yeast   614 ATPAPSAPSAPSARVRGHS-------PHRVVHHHLNIVNS 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	88/354 (25%)
		UBA_SIK	418..458	CDD:270523	5/39 (13%)
PTK1	NP_012723.3	Protein Kinases, catalytic domain	202..503	CDD:473864	84/307 (27%)