Protein Alignment Sik2 and HAL5

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_012370.1
• Gene: HAL5 / 853274
• SGDID: S000003701
• Length: 855
• Species: Saccharomyces cerevisiae
• Alignment Length: 525
• Identity: 112/525 - (21%)
• Similarity: 189/525 - (36%)
• Gaps: 149/525 - (28%)

  Fly    10 GENGSQAKSEES-------------QPPEDQKKKQPQHERNEKQ--LDKPPENLPQNGKTEAKGA 59
            |:|.|:|...:.             :....|:::|.|.|.|.:|  |:|....:|.....:::..
Yeast   340 GDNDSEANMHKQKSVFSLSGLFKSHKDGNQQQQQQQQQEENGEQINLEKAFSIIPSQRFIKSQTL 404

  Fly    60 EGACSHPPLDALRSSVLLDAGAASPSI---DAIVACKDALLAQKLF----------------ASG 105
            :.:.:....:.....::.:.|...|.|   :|.|..::..|...|.                ..|
Yeast   405 KKSRTSNLKNGNNDELMKNDGKNIPQIVNPNAAVGVEELKLINALSEKIRKGLKSENTKGNNGEG 469

  Fly   106 GGSTPGPSPTSSAVGAGGISGKDL----LKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNE 166
            ..::.....:....|..|.:..|.    ...|....:|      .:|.|.:.|||:.....|..:
Yeast   470 RSNSNKQEDSDDTEGKAGTTNDDTSHKPCSQKYGKSIG------VVGAGAYGVVKICARCKTAKD 528

  Fly   167 V--------------AIKIIDKSQLDQTN--LQKVYREVEIMKRLKHPH---------------- 199
            |              |:|.:.....||.:  ..::..|..|...|.|||
Yeast   529 VLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTSEFIIGHSLSHPHFEANAMIAGNVSRTTP 593

  Fly   200 ---------IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSES----------------- 238
                     |:|:..:||..|....|.|:.:.|:::..:.:....:||
Yeast   594 PKHVFNAPNILKILDLMEYSNSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGS 658

  Fly   239 -----AARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSN----------HF 288
                 .|.....|:::.|:|.|..||.|.|||.||:|...|..:||.|||.|:          ||
Yeast   659 PLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPNGLLKICDFGTSSVFQTAWEKHVHF 723

  Fly   289 KPGELLATWCGSPPYAAPEVF-EGKQYTGPEIDIWSLGVVLYVLVCG------ALPFDGSTLQSL 346
            :.|.:     ||.||.|||.| ...:|....:|.||.|:|...:|.|      |:|...|..:|.
Yeast   724 QSGAM-----GSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSF 783

  Fly   347 RDRVL-SGRFRIPFFMSSECEHL-----------IRRMLVLEPTRRYTIDQIKRHRWM----CPE 395
            ...:. .|:    |::..|..|:           :.|...::||:|.||:|:.:..||    |..
Yeast   784 LSEIKDDGQ----FYLFEELRHVSSELNRLRKIALYRTFQVDPTKRITIEQLLQSSWMRKTKCCV 844

  Fly   396 LLEHV 400
            :..|:
Yeast   845 VYRHL 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	82/343 (24%)
		S_TKc	141..392	CDD:214567	82/342 (24%)
HAL5	NP_012370.1	PKc_like	509..837	CDD:419665	82/336 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345288
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840