Protein Alignment Sik2 and KIN2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_013197.1
• Gene: KIN2 / 850785
• SGDID: S000004086
• Length: 1147
• Species: Saccharomyces cerevisiae
• Alignment Length: 1187
• Identity: 265/1187 - (22%)
• Similarity: 419/1187 - (35%)
• Gaps: 404/1187 - (34%)

  Fly    28 KKKQPQHERNEKQLDKPPENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGAASPSIDAIVAC 92
            |:..|::::.:..| .||.::.| ||.:|...:...|.|
Yeast    46 KQSGPRNDQQQAPL-MPPADIKQ-GKEQAAQRQNDASRP-------------------------- 82

  Fly    93 KDALLAQKLFASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKL 157
                                            :|...|:......:|.::...|:|.|:...|||
Yeast    83 --------------------------------NGAVELRQFHRRSLGDWEFLETVGAGSMGKVKL 115

  Fly   158 ARHRITKNEVAIKIIDKSQL----DQTNLQKVYREVEIMKRLK---------------------- 196
            .:||.||....|||::::..    .|.:|.....|.||::|.|
Yeast   116 VKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEIARDKRTVREASLGQIL 180

  Fly   197 -HPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQ-IISAVEYCHKKGI 259
             ||||.:|:::....|..|::.||.|.|::.|||.::|.:.|..|| ||.: |.||::|.|...|
Yeast   181 YHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGSLKEHHAR-KFARGIASALQYLHANNI 244

  Fly   260 VHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSL 324
            ||||||.||:::..:..|||.|||.||.|...:.|.|:|||..:||||:.:.:.|||||:||||.
Yeast   245 VHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQLHTFCGSLYFAAPELLKAQPYTGPEVDIWSF 309

  Fly   325 GVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRH 389
            |:||||||||.:|||......|.:::..|:...|..:|.|...|:.||:|::|.||.|:..:..|
Yeast   310 GIVLYVLVCGKVPFDDENSSILHEKIKKGKVDYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEH 374

  Fly   390 RWM------------------CPELLE-HVLIAKYNLGAERQTSVEPSED----ILRIMA--EYV 429
            .||                  .||::: .||...|.|     ..::..||    ::|::.  ||:
Yeast   375 PWMNRGYDFKAPSYVPNRVPLTPEMIDSQVLKEMYRL-----EFIDDIEDTRRSLIRLVTEKEYI 434

  Fly   430 GIGSD--------KTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNG-----------------L 469
            .:..:        |..:|...|.|.:..|...|:|:.::....||..                 |
Yeast   435 QLSQEYWDKLSNAKGLSSSLNNNYLNSTAQQTLIQNHITSNPSQSGYNEPDSNFEDPTLAYHPLL 499

  Fly   470 GASALASSTSASRMIYSSRND----HQPTQQQSQQQSKTISTSSIL---AKDQCHKRLSRHQTVL 527
            ....|.|...|.::....|..    ....||:.|||...:.|...|   :.|...|..|..:.|
Yeast   500 SIYHLVSEMVARKLAKLQRRQALALQAQAQQRQQQQQVALGTKVALNNNSPDIMTKMRSPQKEV- 563

  Fly   528 MSERNAHAGATPTVPDPGPGYYAKYG--------------------PLQLPLPLTGHSHLTGYLN 572
                         ||:||.......|                    |.:|.:|...|:..|. ..
Yeast   564 -------------VPNPGIFQVPAIGTSGTSNNTNTSNKPPLHVMVPPKLTIPEQAHTSPTS-RK 614

  Fly   573 GGGVEVDASGIPLPMRYTPLPT-------AASPAPSNCSSTSS------RVGRHSLSSSSPRSHR 624
            ...:..:.:|:   ::.||:|.       :|||........::      |:.:...|....|...
Yeast   615 SSDIHTELNGV---LKSTPVPVSGEYQQRSASPVVGEHQEKNTIGGIFRRISQSGQSQHPTRQQE 676

  Fly   625 PVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFI--------------- 674
            |:.     :..|.....:..|:         ::.||   |...:|||::|
Yeast   677 PLP-----EREPPTYMSKSNEI---------SIKVP---KSHSRTISDYIPSARRYPSYVPNSVD 724

  Fly   675 IKQ------------------STEDCRALLQQS-----------------------------TAV 692
            :||                  ...|..||.|.:                             .||
Yeast   725 VKQKPAKNTTIAPPIRSVSQKQNSDLPALPQNAELIVQKQRQKLLQENLDKLQINDNDNNNVNAV 789

  Fly   693 AEG----------------KDDPPKAESSVGGV---------PP-PASTTPTSST-----AGPES 726
            .:|                |..|.....|||..         || ||:..|:..|     .|..:
Yeast   790 VDGINNDNSDHYLSVPKGRKLHPSARAKSVGHARRESLKFTRPPIPAALPPSDMTNDNGFLGEAN 854

  Fly   727 GSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMS-----AEASK--------------LF- 771
            .....|...|..|:...|::.|.|:...|...:..:::     .||||              :|
Yeast   855 KERYNPVSSNFSTVPEDSTTYSNDTNNRLTSVYSQELTEKQILEEASKAPPGSMPSIDYPKSMFL 919

  Fly   772 ------QTLQESPLP--------------------------VEQRTK---RRVHVGSTNGSGGDS 801
                  ||....|||                          |:||..   ..|.|.:|.|.|.||
Yeast   920 KGFFSVQTTSSKPLPIVRHNIISVLTRMNIDFKEVKGGFICVQQRPSIETAAVPVITTTGVGLDS 984

  Fly   802 GQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGN----------DPGSASQESKGS------ 850
            | :..|.:::.||:......:..||::.......||:          .|.:.:...:.|
Yeast   985 G-KAMDLQNSLDSQLSSSYHSTASSASRNSSIKRQGSYKRGQNNIPLTPLATNTHQRNSSIPMSP 1048

  Fly   851 NGGGSGNANGGPTSHSSSDLTRL---VGTTTSGQS-HKMRSYASSSSSSGV-------------- 897
            |.|...|...|..|..|.|..:.   :.||:..|: :.:......:::||:
Yeast  1049 NYGNQSNGTSGELSSMSLDYVQQQDDILTTSRAQNINNVNGQTEQTNTSGIKERPPIKFEIHIVK 1113

  Fly   898 --LAGSAGSYSKSLSQN 912
              :.|.||.:.|.:|.|
Yeast  1114 VRIVGLAGVHFKKVSGN 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	107/279 (38%)
		UBA_SIK	418..458	CDD:270523	12/53 (23%)
KIN2	NP_013197.1	STKc_Kin1_2	97..377	CDD:270979	108/280 (39%)
		KA1	1104..1147	CDD:460465	6/27 (22%)