DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik2 and KCC4

DIOPT Version :9

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_009907.2 Gene:KCC4 / 850334 SGDID:S000000529 Length:1037 Species:Saccharomyces cerevisiae


Alignment Length:946 Identity:239/946 - (25%)
Similarity:379/946 - (40%) Gaps:235/946 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 KEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQL---------DQTNLQKVYRE 188
            |....:|.:.:..|:|.|:...|:||:|..|.:..|:|:|.||..         |......:.||
Yeast    13 KPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIERE 77

  Fly   189 VEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEY 253
            :.|||.|.||:::.||.|.||.|.:|::.|||.:||:|:.:..:|.:.|..|...|.|||..:.|
Yeast    78 IVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISY 142

  Fly   254 CHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPE 318
            ||..||||||||.||||||...||||||||.:......:||.|.||||.|||||:..|..|.|..
Yeast   143 CHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFA 207

  Fly   319 IDIWSLGVVLYVLVCGALPFD--GSTLQSLRDRVLSGRFRIP--FFMSSECEHLIRRMLVLEPTR 379
            .|:||.||:|:.|:.|.||||  ...::.|..:|..|:|.:|  ..:|.:.:.||.::||::|.:
Yeast   208 SDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQ 272

  Fly   380 RYTIDQIKRHRWMCPELLEHVLIAKYN---------------------LGAERQTSVEPSEDILR 423
            |..|          .::|.|.|:.||.                     ..:...||....:.||:
Yeast   273 RIKI----------RDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSASIDDSILQ 327

  Fly   424 -IMAEYVGIGSDKTRASLKKNTYDHVAAIYLLL------QDRVSHKKEQS------NGLGASALA 475
             ::..:.|..:|...:.||:|..:....:|.||      ..|.|:||.::      ....:|.|:
Yeast   328 NLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKNKRSSTLS 392

  Fly   476 SSTSA---SRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGA 537
            ||:|.   :|.|.|:     |.::.|::.|:..|:|        .||.|    .|:|       :
Yeast   393 SSSSLLLNNRSIQST-----PRRRTSKRHSREFSSS--------RKRSS----FLLS-------S 433

  Fly   538 TPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDA--SGIPLP------------MR 588
            .||...              |:||.....:| ::|.......|  ||:|.|            :.
Yeast   434 NPTDSS--------------PIPLRSSKRIT-HINVASANTQATPSGVPNPHKRNSKKRSSKRLS 483

  Fly   589 YTPLPTAASPAPSNCSSTSSRVGRHS---LSSSSPRSHRPVAISLSIDNNPSLANLRCRE----- 645
            |.|....:|....:.|:.::.:....   :...:.|:....|..:.....|....|..||     
Yeast   484 YMPNTKRSSLTSKSLSNFTNLIDDDDWEYIEKDAKRTSSNFATLIDEIFEPEKFELAKREKAELQ 548

  Fly   646 --MMEAGGGPVGA-------VGVPLAS-----KQLHQTIS------EFIIKQSTEDCRALLQQST 690
              :.||....|.|       .|..::.     |:::..:|      ||..::..:|...||....
Yeast   549 RKVQEAKRQSVNAQKINEDEFGSEVSDGMKELKKINDKVSSPLINYEFSQQELLQDIDTLLTNRY 613

  Fly   691 AVAE-----GKDDPPKAESSVGGVPPPASTTPTS---STAGPESGSAPCPGEINGKTIKTMSSSS 747
            .::.     .:.||        |:.|...|.|.:   .||..:        :...|.|:|:..|.
Yeast   614 QLSSYTRPISRLDP--------GLTPVTETLPNNLKEKTALLQ--------DTEKKIIETIRRSK 662

  Fly   748 SFDSKANLGQSFRYKMSAEASKLFQTLQESPL--------------------PVEQRTKRRVHVG 792
            ...|..|:    |..:|...|:| ..::|||:                    .|...|::..|..
Yeast   663 FLGSLLNV----RGGLSPGKSEL-APIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFT 722

  Fly   793 STNGS-------GGDSGQETND------------AKSNGDSRSEKKVLAQG-SSSTDEGCETDQG 837
            :.|..       ..||.::.|:            ..::.:||||...:|:. :.|.:...:.|..
Yeast   723 TANNRRSVLSLYAKDSIKDLNEFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQYDEDDS 787

  Fly   838 NDPGSASQE---SKGSNGGG--------SGNANGGPTSHSSS--------DLTRLVGTTTSGQSH 883
            .|..:.:.:   |....|.|        ..|.|..|.|.|:.        .|:...|...||...
Yeast   788 KDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNASGLGL 852

  Fly   884 KMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRGSSK 919
            ..|      ..|.|...|..|.:.|:.:|:..|:.|
Yeast   853 YQR------EPSKVTLPSLTSNNSSVGENIEDGAEK 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 107/264 (41%)
S_TKc 141..392 CDD:214567 107/263 (41%)
KCC4NP_009907.2 PKc_like 19..285 CDD:419665 110/275 (40%)
Kcc4p_like_C 920..1034 CDD:213379
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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