Protein Alignment Sik2 and TSSK1B

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_114417.1
• Gene: TSSK1B / 83942
• HGNCID: 14968
• Length: 367
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 123/310 - (39%)
• Similarity: 173/310 - (55%)
• Gaps: 34/310 - (10%)

  Fly   147 IGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK-VYREVEIMKRLKHPHIIKLYQVMETK 210
            :|:|::|.||.|.....|..|||||||:.:.....|:| :.||:||:..|.|..|||.|::.||.
Human    18 LGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETS 82

  Fly   211 N-MIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLN 274
            : .:|||.|.|.||::.:.|...|.:.|..||.||.|:..|::|||...:||||||.:|||||.:
Human    83 HGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKD 147

  Fly   275 MNIKIADFGFSNHFKPGE-----LLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCG 334
            .|||::||.||......:     |..|:||||.||||||.:|..|.....|||||||:||::|||
Human   148 FNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCG 212

  Fly   335 ALPFDGSTLQS-LRDRVLSGRFRIPF----FMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            ::|:|.|.::. ||   :....|:.|    .::.||:.||..||..:..||..||:|..|.||.|
Human   213 SMPYDDSNIKKMLR---IQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQP 274

  Fly   395 ELLEHVLIA-----KYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRAS 439
            :......:|     :.:.|.|...:.||              ||||..|:
Human   275 KARGSPSVAINKEGESSRGTEPLWTPEP--------------GSDKKSAT 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	110/256 (43%)
		UBA_SIK	418..458	CDD:270523	5/22 (23%)
TSSK1B	NP_114417.1	STKc_TSSK1_2-like	10..272	CDD:271067	110/256 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..367		10/49 (20%)