Protein Alignment Sik2 and Nuak1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001004363.1
• Gene: Nuak1 / 77976
• MGIID: 1925226
• Length: 658
• Species: Mus musculus
• Alignment Length: 756
• Identity: 229/756 - (30%)
• Similarity: 329/756 - (43%)
• Gaps: 206/756 - (27%)

  Fly   103 ASGGG-----STPGPSPTSSAVGA----------GGIS---GKDLLKLKEPMRVGFYDIERTIGK 149
            |:|.|     ..|| ||..:..||          .|:.   .|..||.:       |:::.|:||
Mouse     8 AAGDGPAVETGLPG-SPLEAVAGATAAPVEPRKPHGVKRHHHKHNLKHR-------YELQETLGK 64

  Fly   150 GNFAVVKLARHRITKNEVAIKIIDKSQL-DQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMI 213
            |.:..||.|..|.:...||||.|.|.:: |:.::..:.||:|||..|.|||||.:|:|.|.|:.|
Mouse    65 GTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHIISIYEVFENKDKI 129

  Fly   214 YIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIK 278
            .|:.||||:||::|||::..|:||...|..|.||:|||.||||.|:||||||.||:|||.|.|||
Mouse   130 VIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIK 194

  Fly   279 IADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTL 343
            |||||.||.::..:.|.|:||||.||:||:..|:.|.|||:|.|:|||:||.|:.|.:||||...
Mouse   195 IADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLIYGTMPFDGFDH 259

  Fly   344 QSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM----------CPEL-- 396
            ::|..::.||.:|.| ...|:...|||.||::.|.||.||:.|..|.|:          |..|
Mouse   260 KNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALPD 323

  Fly   397 LEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSD-------KTRASLKKNTYDHVAAIYLL 454
            .|..|:|:......|.|.::...:     |:..|:...       :.:.||||:
Mouse   324 SESPLLARIIDWHHRSTGLQAEAE-----AKMKGLAKPGASEVVLERQRSLKKS----------- 372

  Fly   455 LQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKR 519
                   |||                        ||.    .||.|.|...|.|.:.:|
Mouse   373 -------KKE------------------------NDF----PQSGQDSVPESPSKLSSK------ 396

  Fly   520 LSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIP 584
              |.:.:|....|:.                            ..||.||::.|    :.:..:|
Mouse   397 --RPKGILKKRSNSE----------------------------HRSHSTGFIEG----IVSPALP 427

  Fly   585 LPMRY-TPLPTAASPAPSNCSSTSSRVGRHSL--SSSSPR-------SHRPVAISLSIDNNPSLA 639
            .|.:. ..|...|.|.||:..:..|  |:.||  |::.|:       ..|......|.:.:.|..
Mouse   428 SPFKMEQDLCRTAIPLPSSPEADMS--GKLSLKQSATMPKKGILKKTQQRESGYYSSPERSESSE 490

  Fly   640 NLRCREMMEAGG--GPVGAVGVPLASKQLHQTISEFIIKQSTEDCR--ALLQQSTAVAEGKDDP- 699
            .|...:::.:||  .|     .|..::....::|          ||  .:|:.|:..::|..||
Mouse   491 LLDSNDVVISGGLSSP-----PPDPARGTSHSLS----------CRRKGILKHSSRYSDGGTDPA 540

  Fly   700 ------PKAES-SVGGVPPPA---STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFD---- 750
                  |..|| |..|||...   |.:..||....:|                :.||.|||
Mouse   541 LTRPEMPTLESLSPPGVPSDGISRSYSRPSSIISDDS----------------VLSSDSFDLLEL 589

  Fly   751 -SKANLGQSFRYKMSAE---ASKLFQTLQESPLPVEQRTKR 787
             ......|..|..:|||   ..:.|:|....|.|  |..||
Mouse   590 QENRPARQRIRSCVSAENFLQLQDFETPHNRPRP--QYLKR 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	125/252 (50%)
		UBA_SIK	418..458	CDD:270523	6/46 (13%)
Nuak1	NP_001004363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..53		11/45 (24%)
		STKc_NUAK	54..307	CDD:270975	125/260 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..422		24/154 (16%)
		GILK motif	400..403		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..568		33/143 (23%)