DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and mark3b

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_009293196.1	Gene:	mark3b / 767634	ZFINID:	ZDB-GENE-060929-80	Length:	834	Species:	Danio rerio

Alignment Length:	1019	Identity:	311/1019 - (30%)
Similarity:	445/1019 - (43%)	Gaps:	312/1019 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 TPGPSPTSSAVGAGGISGKDLLK--LKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKI 171
            |.|.:..:|..|..|...::.:.  ..|...:|.|.:.:||||||||.||||||.:|..||||||
Zfish    42 TDGRNEVASRPGRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKI 106

  Fly   172 IDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMS 236
            |||:||:.|:|||::|||.|||.|.||:|:||::|:||...:|:|.||||.||:|||:..:|||.
Zfish   107 IDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMK 171

  Fly   237 ESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSP 301
            |..||.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|..|.|:||||
Zfish   172 EKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFTIGNKLDTFCGSP 236

  Fly   302 PYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECE 366
            ||||||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||||:||::||
Zfish   237 PYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCE 301

  Fly   367 HLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQ---TSVEPSEDI-----LR 423
            :|::|.|||.|.:|.|::||.:.||:             |.|.|.:   ..|||..||     :.
Zfish   302 NLLKRFLVLNPVKRGTLEQIMKDRWI-------------NAGCEEEELKPFVEPELDISDQKRID 353

  Fly   424 IMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYS 486
            ||   ||:|  .::...||.:..||.:.|.|||| .|.|.:.|.|:        ||:|::..:..
Zfish   354 IM---VGMGYSREEIHESLTRMKYDEITATYLLL-GRKSTELEVSD--------SSSSSNLSLAK 406

  Fly   487 SRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAK 551
            :|    |..:.:..||.:            |.::.::.:....:|.....|.||:|.
Zfish   407 AR----PNSEHNNGQSPS------------HLKVQKNASTNQKQRRYSDQAGPTIPS-------- 447

  Fly   552 YGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLS 616
                            .||                    |..:..:.|.|......|...|.| |
Zfish   448 ----------------VGY--------------------PKRSQTTSAESEHKEEGSAQARKS-S 475

  Fly   617 SSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTED 681
            ||..|...|.:..|...|||:.|::..|:.      ..||.|        :.::|..:.:::|..
Zfish   476 SSGSRGMAPASPMLGNANNPNKADIPDRKK------SAGAPG--------NNSVSSGMTRRNTYV 526

  Fly   682 C--RALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMS 744
            |  |....:.:.:..||      |:|:..:....||:||:                  ..:...|
Zfish   527 CSERNATDRHSVIQNGK------ENSLSEMSGCVSTSPTA------------------YAVALAS 567

  Fly   745 SSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAK 809
            ||:|.        ..|::.:|..|....|.: :.||                        |:||.
Zfish   568 SSASV--------RLRHQKAASLSASGHTCR-ATLP------------------------TSDAS 599

  Fly   810 SNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQE-----------------SKGSNGGG--- 854
            ::         |.:.::||   .:|.|.| |||::..                 |:.:..||
Zfish   600 AD---------LFRPNTST---AQTSQRN-PGSSTHSISSATPPDRLRFPRGTLSRSTFHGGQLR 651

  Fly   855 ---SGNANGGPTSHS-SSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSR 915
               :...||.|.|.: |.|.|.|..:.:.|.::......                ||...:|:|.
Zfish   652 ERRTATYNGPPASPTLSHDATPLSQSRSRGSTNLFTKLT----------------SKLTRRNMSF 700

  Fly   916 GSSK---SNC--SGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSERSLYG 975
            ..||   :.|  :|.||.                              |...:|.:...|..
Zfish   701 RFSKRVPAECDRNGRYDD------------------------------SSRNVSGDQKEEHK--- 732

  Fly   976 SHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDGLVAQGL 1040
                     .|.|..|....|..:|.:..||.                ..||.|:..|.
Zfish   733 ---------DAKPRSLRFTWSMKTTSSMEPTE----------------MMREIRKVLDA------ 766

  Fly  1041 LSSGSLLGTSRVYGSYRYEQAKR------HGWLEIQQLQQLQQE 1078
                         .:..|||.:|      ||....:.|.|.:.|
Zfish   767 -------------NNCDYEQRERFLLLCVHGDGHAESLVQWEME 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	163/251 (65%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	163/250 (65%)
mark3b	XP_009293196.1	STKc_MARK	75..327	CDD:270974	163/251 (65%)
		S_TKc	76..327	CDD:214567	163/250 (65%)
		UBA_MARK3_4	345..387	CDD:270590	16/45 (36%)
		MARK1-3_C	735..832	CDD:213381	19/98 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810