Protein Alignment Sik2 and Brsk2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001009930.1
• Gene: Brsk2 / 75770
• MGIID: 1923020
• Length: 719
• Species: Mus musculus
• Alignment Length: 820
• Identity: 228/820 - (27%)
• Similarity: 358/820 - (43%)
• Gaps: 185/820 - (22%)

  Fly   125 SGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREV 189
            :|||....:....||.|.:|:|:|||...:|||..|.:|..:|||||:::.:|.::.|.||.||:
Mouse     4 TGKDGGGAQHAQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREI 68

  Fly   190 EIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYC 254
            .|:|.::|||::||:.|.|.|..:|:|.|:.|.||:|||:.|.||::...||..|.|||||:::|
Mouse    69 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 133

  Fly   255 HKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEI 319
            |...|.|||||.||||||...||:|||||.::......||.|.||||.||.|||..|::|.|.:.
Mouse   134 HSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKA 198

  Fly   320 DIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTID 384
            |:||.||:|:.|:.||||||...|:.|.::|..|.|.:|.|:..:|:.|:|.|:.::..||.|::
Mouse   199 DVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLE 263

  Fly   385 QIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVA 449
            .|::|.|.              :|.:.:.  ||.:.|.|    .|.|.|..:...:..:..|.:.
Mouse   264 HIQKHIWY--------------IGGKNEP--EPEQPIPR----KVQIRSLPSLEDIDPDVLDSMH 308

  Fly   450 AI------YLLLQDRVSHKKEQSNGLGASALASSTSASRMIY---SSRNDHQPTQQQSQQQSKTI 505
            ::      ..||||.:|.::.|               .:|||   ..|.:..|:.:......:.
Mouse   309 SLGCFRDRNKLLQDLLSEEENQ---------------EKMIYFLLLDRKERYPSHEDEDLPPRN- 357

  Fly   506 STSSILAKDQCHKR-----LSRH-----QTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLP 560
                  ..|...||     |:||     :...|...:...|.:|.             |.:..:.
Mouse   358 ------EIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGGSPV-------------PARRAIE 403

  Fly   561 LTGHSHLTGYLNGGGVEVDASGIPLPM-------RYTPLPT-------------AASPAPSNCSS 605
            :..|...:..::|....:..|.:..|.       |.:||||             |.:|.|:..||
Mouse   404 MAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVHTPKESPAGTPNPTPPSS 468

  Fly   606 TSS-----RVGRHSLSSS---SPRSHR-------PVAIS-LSIDNNPSLA---------NLRCRE 645
            .|.     |...:|:.:|   |||.||       |..:| |:.:::|.||         ||...|
Mouse   469 PSVGGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMSNLTPESSPELAKKSWFGNFINLEKEE 533

  Fly   646 MMEAGGGPVGAVGVPLASKQ---LHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVG 707
            .:.     |.....||:|.:   :|..:|...:..|      ::.|::..||.|        :.|
Mouse   534 QIF-----VVIKDKPLSSIKADIVHAFLSIPSLSHS------VISQTSFRAEYK--------ATG 579

  Fly   708 GVPPPASTTPTS---STAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASK 769
            |  |.....|..   .....|.|.|.....|...|...:|           |.|.|:|      :
Mouse   580 G--PAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLS-----------GPSRRFK------R 625

  Fly   770 LFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCET 834
            :.:|:|...|....:...:....:||.....:|:.:...:.||.:       ||..|:
Mouse   626 VVETIQAQLLSTHDQPSAQHLSDTTNCMEVMTGRLSKCDEKNGQA-------AQAPST------- 676

  Fly   835 DQGNDPGSASQESKGSNGGGSGNANGGPTSH-SSSDLTRL 873
                   .|.:.:.|..|..:....||.|.: ...|:.::
Mouse   677 -------PAKRSAHGPLGDSAAAGPGGDTEYPMGKDMAKM 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	117/251 (47%)
		UBA_SIK	418..458	CDD:270523	9/45 (20%)
Brsk2	NP_001009930.1	STKc_BRSK1_2	18..271	CDD:270983	118/252 (47%)
		UBA_BRSK	298..351	CDD:270525	12/67 (18%)