Protein Alignment Sik2 and Tssk5

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_898922.2
• Gene: Tssk5 / 73542
• MGIID: 1920792
• Length: 372
• Species: Mus musculus
• Alignment Length: 358
• Identity: 124/358 - (34%)
• Similarity: 183/358 - (51%)
• Gaps: 51/358 - (14%)

  Fly   131 KLKEPMRVGFYDIERTIGKGNFAVVKLA---RHRITKNE-------------VAIKIIDKSQLDQ 179
            :::|.|..|:....:.||.|.|:.|.||   |.|:..|.             |||||:..::...
Mouse    17 QVRECMNNGYLLSSKKIGSGAFSKVYLAYATRERMKHNPRLSSDLRGKRHTMVAIKIVSMAEAPA 81

  Fly   180 TNLQK-VYREV-EIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYG------RMS 236
            ...:| :.||: .:....||.:|::||:..:.....|:|.|.|::|::.::|....      .:.
Mouse    82 EYSRKFLPREILSLNATYKHMNIVQLYETYQNSQRSYLVLELAARGDLLEHINAVSDLRCCPGLE 146

  Fly   237 ESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHF-KPGELLATWCGS 300
            |..||..|||::|||.:||..||||||||.||:|||....||:.||||:|.. ....||:|:|||
Mouse   147 EEEARRLFWQLVSAVAHCHNVGIVHRDLKCENILLDDQGFIKLTDFGFANWVGLKNSLLSTFCGS 211

  Fly   301 PPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFF---MS 362
            ..|.|||:...|:|.|.:.|:||||::|:.:|.|.|||.    :....|:|:...|.|.|   :|
Mouse   212 VAYTAPEILMSKKYNGEQADLWSLGIILHAMVSGKLPFK----EHQPHRMLNLIRRGPIFRPGLS 272

  Fly   363 SECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQ----------TSVEP 417
            .||..|||.:|.|.|..|..:.|:..|.||.|  .||:|.:.  |||.|:          .:.||
Mouse   273 PECRDLIRGLLQLHPCERLDLQQVAAHCWMLP--AEHMLSSA--LGAPREQDHSWSTVAPDNTEP 333

  Fly   418 SEDILRIMAEYVGIGSDKT---RASLKK--NTY 445
            ..|.....::.....|.:|   |.||.:  ||:
Mouse   334 DRDTRHARSKGSSSSSGRTSPRRPSLAQLCNTW 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	101/279 (36%)
		UBA_SIK	418..458	CDD:270523	8/33 (24%)
Tssk5	NP_898922.2	Protein Kinases, catalytic domain	26..301	CDD:473864	101/278 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	314..372		13/53 (25%)