DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and Sik3

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_081774.3	Gene:	Sik3 / 70661	MGIID:	2446296	Length:	1369	Species:	Mus musculus

Alignment Length:	1515	Identity:	437/1515 - (28%)
Similarity:	596/1515 - (39%)	Gaps:	491/1515 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ASGGGSTP----------GPSPTSSAVGAGGISGKDLLKLKE---PMRVGFYDIERTIGKGNFAV 154
            |..||:.|          ||....:||....:..:.......   ..|:|:|:|:||||||||||
Mouse    15 AGAGGAGPAGRLLPPPAAGPPAAPAAVPPAAVPARPTAPASRGSMAARIGYYEIDRTIGKGNFAV 79

  Fly   155 VKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEY 219
            ||.|.|.:||.:||||||||||||:.||:|::|||:|||.|.|||||:|||||||:.|||:|:||
Mouse    80 VKRATHLVTKAKVAIKIIDKSQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEY 144

  Fly   220 ASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGF 284
            ||.|||||::..:|||:|..||.||.||::||.:||.:.||||||||||||||.|:|||||||||
Mouse   145 ASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGF 209

  Fly   285 SNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDR 349
            ||.|.||:||.||||||||||||:||||:|.||::|||||||||||||||||||||||||:||.|
Mouse   210 SNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRAR 274

  Fly   350 VLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM---------------CPELLEH 399
            ||||:||||||||:|||||||.||||:|.:|.:::||.||:||               |.:|.|
Mouse   275 VLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGDADPNFDRLIAECQQLKE- 338

  Fly   400 VLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKE 464
                      |||:  :|..|.:.:..|.:|:..::|..||:.:.|||.:|||.||.||  |||.
Mouse   339 ----------ERQS--DPLNDDVLLAMEDMGLDKERTLQSLRSDAYDHYSAIYSLLCDR--HKKH 389

  Fly   465 QSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTS-----------SILAKDQC-- 516
            ::  |...||.|...|  |.:.:     |...|::|....::.|           .|:..|..
Mouse   390 KT--LRPGALPSMPQA--MTFQA-----PVNLQAEQTGTAMNLSVPQVQLINPENQIIEPDGAVN 445

  Fly   517 ----------------HKRLSRH-------QTVLMSERNAHAGATPTVPDPGPGY---------- 548
                            :..:.||       :|.:|.:........|.|...||..
Mouse   446 LDSDEGEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQGPFLQVAPNMNFTH 510

  Fly   549 ---------------YAKYGPLQLPL--PLTGHSHLTGYLNGGG--VEVDASGI------PLPM- 587
                           |.:...||.|.  .|.|...|....:.||  :::.|..:      |.|:
Mouse   511 NLLPMQSLQPTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLV 575

  Fly   588 RYTPLPTAASPAPSNCSS-----------TSSRVGRHSLSSSSPRSHRPVAISLSIDNN------ 635
            ..||...|.:|.....|.           .::|..||:|:.:||.:..|..:...:...
Mouse   576 TMTPAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTSPTAEIPPDLQRQLGQQSFRSRV 640

  Fly   636 --PSLANLRCREMMEAGG---------GPV-----GAVGVPLASKQLHQTISEFIIKQSTEDCRA 684
              |.|...:.|...:...         .||     ||..:......|.:..:...|||..::|..
Mouse   641 WPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNSSSIKQLQQECEQ 705

  Fly   685 LLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTI-KTMSSSSS 748
            |                 :...|                         |:::.:|: ||..
Mouse   706 L-----------------QKMYG-------------------------GQVDERTLEKTQQ---- 724

  Fly   749 FDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGD 813
                    |...|:.......|.|.:|:|..|
Mouse   725 --------QHMLYQQEQHHQILQQQIQDSICP--------------------------------- 748

  Fly   814 SRSEKKVLAQGSSSTDEGCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTT 878
                    .|.|......||    |.|...:.:.:...    ...:..|.:|.|:.|.|
Mouse   749 --------PQPSPPLQVACE----NQPALLTHQLQRLR----IQPSSPPPNHPSNHLFR------ 791

  Fly   879 SGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNL-SRGS----SKSNCSGPYDSLDFALPSGKG 938
                   :...|....|..:..|.|:.|.|..|.| |.|:    ...|||.|
Mouse   792 -------QPSNSPPPVSSAMITSHGATSPSQFQGLPSHGAIFQQQPENCSPP------------- 836

  Fly   939 SLPS----CMG----SSS------------MLATPTPASASPAGISSEHS-SERSLYGSHNSCIH 982
              ||    |:|    |.|            ||:.....:|..||.|...| |...:...|.:.:.
Mouse   837 --PSVALTCLGLQQASQSQPVTIQLQEPVDMLSNMAGTAAGSAGRSIPISPSASQIQIQHRASLM 899

  Fly   983 MP---GALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDGLVAQGLLSSG 1044
            .|   |..||...|...||...:.|            :::.||.:
Mouse   900 APFSYGHRPLSKQLSADSAEAHSLN------------MNRFSPAN-------------------- 932

  Fly  1045 SLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQHPHPHPQAYGLEELC 1109
                         |:||                     |.|||...   ......|.:|......
Mouse   933 -------------YDQA---------------------HLHPHLFS---DQSRGSPSSYSPSTGV 960

  Fly  1110 QFPNGQFYALPGKHHPLLTLPHHHAHP--AQHHHGHHSLFHSGHQATPLLLEAAAGGDMYGHGCY 1172
            .||..|...:|    ||...|   ..|  ||....|::        |..|.:|          ..
Mouse   961 GFPPTQALKVP----PLDQFP---TFPPSAQQQPPHYT--------TSALQQA----------LL 1000

  Fly  1173 APPPPPPGLYTHHQ----LGVGMAVPM------SPMQKPPLQ-QQLL----QHRLLQQKRQLFQK 1222
            :|.||.   |..||    :..|:..|.      |.::.||.: .||:    |||..||::|. |:
Mouse  1001 SPTPPD---YPRHQQVPHILQGLLSPRHSLTGHSDIRLPPAEFAQLIKRQQQHRQQQQQQQQ-QQ 1061

  Fly  1223 QY-------------ALEAQLAGRHHHHQQ-------HSHHHHH----HFGH-------SLGPPP 1256
            :|             :|...|.|::...||       .|:|.||    |...       |.||.|
Mouse  1062 EYHELFRHMNQGDAVSLAPSLGGQNMTEQQALSYQNADSYHRHHTSPQHILQIRAQDCISQGPSP 1126

  Fly  1257 PPAPAPEH-----HLADELYELALLDRPRSGTPRLQHSMTMPGAHAFSQMNLKTSYISQSDQVPG 1316
            .|.....|     | ::.:.|..|.:..:.|.|....|....|.|. |.:.|.||.....:.:.|
Mouse  1127 TPTHGYAHQPPLMH-SESMEEDCLCEGLKEGFPDKSSSTLTKGCHN-SPLLLCTSGPGDPEPLLG 1189

  Fly  1317 AAPNGAGSGGSAAGVSCSAPPSTAPGTPTVKCKPTTPHGHS-LDSDYHTSTPVLSLFTPNWQSL- 1379
            ..     |.....|:.   |....| |.|...:...|...| |.:....|:|..::..|:...|
Mouse  1190 TV-----SQARELGIH---PYGHQP-TATTFSRNKVPSRESVLGNCLERSSPGQAMELPDHNGLG 1245

  Fly  1380 --VKPLSESPILEISEHLES 1397
              |:||       :||||.|
Mouse  1246 YPVRPL-------VSEHLRS 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	186/251 (74%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	186/250 (74%)
Sik3	NP_081774.3	STKc_SIK	65..317	CDD:270973	186/251 (74%)
		S_TKc	66..317	CDD:214567	186/250 (74%)
		UBA_SIK3	346..390	CDD:270593	19/45 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810