DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik2 and Mark4

DIOPT Version :9

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_001178000.1 Gene:Mark4 / 680407 RGDID:1591792 Length:752 Species:Rattus norvegicus


Alignment Length:710 Identity:262/710 - (36%)
Similarity:358/710 - (50%) Gaps:160/710 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 SGGGSTPGPSPTSSAVGA---GGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKN 165
            ||..|..|||.:|.::||   ..|:...    :|...||.|.:.|||||||||.||||||.:|..
  Rat    23 SGRSSDKGPSWSSRSLGARCRNSIASCP----EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGR 83

  Fly   166 EVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIA 230
            |||||||||:||:.::|||::|||.|||.|.||:|:||::|:||:..:|:|.||||.||:|||:.
  Rat    84 EVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLV 148

  Fly   231 KYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLA 295
            .:|||.|..||.||.||:|||.|||:|.||||||||||||||...|||||||||||.|..|..|.
  Rat   149 SHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213

  Fly   296 TWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFF 360
            |:||||||||||:|:||:|.|||:|||||||:||.||.|:|||||..|:.||:|||.|::|:||:
  Rat   214 TFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFY 278

  Fly   361 MSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNL---GAERQTSVEPSEDI- 421
            ||::||.::||.|||.|.:|.|::||.:.:|:             |:   |.|.:...||.||. 
  Rat   279 MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI-------------NIGYEGEELKPYTEPEEDFG 330

  Fly   422 ----LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALA----- 475
                :.:|   ||:|  .::.:.:|....|:.|.|.||||    ..|.|:....||..||     
  Rat   331 DTKRIEVM---VGMGYTREEIKEALTNQKYNEVTATYLLL----GRKTEEGGDRGAPGLALARVR 388

  Fly   476 ------SSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAH 534
                  :.||:|:  .||.|..|.|...:..:.:..|       |.|.                 
  Rat   389 APSDTTNGTSSSK--GSSHNKGQRTSSSTYHRQRRHS-------DFCG----------------- 427

  Fly   535 AGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPA 599
                   |.|.| .:.|..|                .:.|..|:....:|             ..
  Rat   428 -------PSPAP-LHPKRSP----------------TSTGDTELKEERLP-------------GR 455

  Fly   600 PSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASK 664
            .::||:..|  |...|..|||        .:|..:||:.|.                  :|...|
  Rat   456 KASCSAAGS--GSRGLPPSSP--------MVSSAHNPNKAE------------------IPERRK 492

  Fly   665 QLHQTIS----EFIIKQSTEDC--RALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAG 723
            ....|.:    ..:.:::|..|  |...::.:.:..||::    .|....|||   .:|:|.:..
  Rat   493 DSTSTPNNLPPSMMTRRNTYVCTERPGSERQSLLPNGKEN----SSGTSRVPP---ASPSSHSLA 550

  Fly   724 PESGSAPCPGEINGKTIK-TMSSSSSFDSKANLGQSFRYKMSAEASKLFQTL--QESPLP 780
            |.||..  .....|.||: |.......|.:|..|.....:....||   .||  :.:|||
  Rat   551 PPSGER--SRLARGSTIRSTFHGGQVRDRRAGGGSGGGVQNGPPAS---PTLAHEAAPLP 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 161/251 (64%)
S_TKc 141..392 CDD:214567 161/250 (64%)
Mark4NP_001178000.1 STKc_MARK 58..310 CDD:270974 161/251 (64%)
S_TKc 59..310 CDD:214567 161/250 (64%)
UBA_MARK3_4 328..370 CDD:270590 13/48 (27%)
MARK4_C 654..752 CDD:213382
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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