Protein Alignment Sik2 and Mark4

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001178000.1
• Gene: Mark4 / 680407
• RGDID: 1591792
• Length: 752
• Species: Rattus norvegicus
• Alignment Length: 710
• Identity: 262/710 - (36%)
• Similarity: 358/710 - (50%)
• Gaps: 160/710 - (22%)

  Fly   104 SGGGSTPGPSPTSSAVGA---GGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKN 165
            ||..|..|||.:|.::||   ..|:...    :|...||.|.:.|||||||||.||||||.:|..
  Rat    23 SGRSSDKGPSWSSRSLGARCRNSIASCP----EEQPHVGNYRLLRTIGKGNFAKVKLARHILTGR 83

  Fly   166 EVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIA 230
            |||||||||:||:.::|||::|||.|||.|.||:|:||::|:||:..:|:|.||||.||:|||:.
  Rat    84 EVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLV 148

  Fly   231 KYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLA 295
            .:|||.|..||.||.||:|||.|||:|.||||||||||||||...|||||||||||.|..|..|.
  Rat   149 SHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLD 213

  Fly   296 TWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFF 360
            |:||||||||||:|:||:|.|||:|||||||:||.||.|:|||||..|:.||:|||.|::|:||:
  Rat   214 TFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFY 278

  Fly   361 MSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNL---GAERQTSVEPSEDI- 421
            ||::||.::||.|||.|.:|.|::||.:.:|:             |:   |.|.:...||.||.
  Rat   279 MSTDCESILRRFLVLNPAKRCTLEQIMKDKWI-------------NIGYEGEELKPYTEPEEDFG 330

  Fly   422 ----LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALA----- 475
                :.:|   ||:|  .::.:.:|....|:.|.|.||||    ..|.|:....||..||
  Rat   331 DTKRIEVM---VGMGYTREEIKEALTNQKYNEVTATYLLL----GRKTEEGGDRGAPGLALARVR 388

  Fly   476 ------SSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAH 534
                  :.||:|:  .||.|..|.|...:..:.:..|       |.|.
  Rat   389 APSDTTNGTSSSK--GSSHNKGQRTSSSTYHRQRRHS-------DFCG----------------- 427

  Fly   535 AGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPA 599
                   |.|.| .:.|..|                .:.|..|:....:|             ..
  Rat   428 -------PSPAP-LHPKRSP----------------TSTGDTELKEERLP-------------GR 455

  Fly   600 PSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASK 664
            .::||:..|  |...|..|||        .:|..:||:.|.                  :|...|
  Rat   456 KASCSAAGS--GSRGLPPSSP--------MVSSAHNPNKAE------------------IPERRK 492

  Fly   665 QLHQTIS----EFIIKQSTEDC--RALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAG 723
            ....|.:    ..:.:::|..|  |...::.:.:..||::    .|....|||   .:|:|.:..
  Rat   493 DSTSTPNNLPPSMMTRRNTYVCTERPGSERQSLLPNGKEN----SSGTSRVPP---ASPSSHSLA 550

  Fly   724 PESGSAPCPGEINGKTIK-TMSSSSSFDSKANLGQSFRYKMSAEASKLFQTL--QESPLP 780
            |.||..  .....|.||: |.......|.:|..|.....:....||   .||  :.:|||
  Rat   551 PPSGER--SRLARGSTIRSTFHGGQVRDRRAGGGSGGGVQNGPPAS---PTLAHEAAPLP 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	161/251 (64%)
		UBA_SIK	418..458	CDD:270523	14/46 (30%)
Mark4	NP_001178000.1	STKc_MARK	58..310	CDD:270974	161/251 (64%)
		UBA_MARK3_4	328..370	CDD:270590	13/48 (27%)
		MARK4_C	654..752	CDD:213382