Protein Alignment Sik2 and Prkaa1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_062015.2
• Gene: Prkaa1 / 65248
• RGDID: 3387
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 183/550 - (33%)
• Similarity: 277/550 - (50%)
• Gaps: 91/550 - (16%)

  Fly   136 MRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTN-LQKVYREVEIMKRLKHPH 199
            :::|.|.:..|:|.|.|..||:.:|.:|.::||:||:::.::...: :.|:.||::.:|..:|||
  Rat    22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||:.|.:.|::|.||.|.||:||||.|.||:.|..:|..|.||:|.|:|||:..:|||||
  Rat    87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDL 151

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            |.||:|||.:||.||||||.||....||.|.|.||||.||||||..|:.|.|||:||||.||:||
  Rat   152 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILY 216

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            .|:||.||||...:.:|..::..|.|..|.:::.....|::.||.::|.:|.||..|:.|.|...
  Rat   217 ALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 281

  Fly   395 ELLEHVLIAKYNLGAE-RQTSVEPSEDILRIMAEYVGIGSDKTRASL-KKNTYDHVAAIYLLLQD 457
            :|      .||....: ..:|....::.|:.:.|......::..:.| .:|..|.:|..|.|:.|
  Rat   282 DL------PKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIID 340

  Fly   458 --RVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQ----QSKTISTSSILAKDQC 516
              |:.::.:.      ..||:|...|.:     :||..|:...::    .::|......|  |:.
  Rat   341 NRRIMNEAKD------FYLATSPPDSFL-----DDHHLTRPHPERVPFLVAETPRARHTL--DEL 392

  Fly   517 HKRLSRHQTVLMSERNA--HAG----ATPT------------------VPDPGPGYYAK------ 551
            :.:.|:||.|    |.|  |.|    :.|.                  |.:|   ||.:
  Rat   393 NPQKSKHQGV----RKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNP---YYLRVRRKNP 450

  Fly   552 ----YGPLQLPL-PLTGHSHLTGYLNGGGVEVDA-SGIPLPMR------YTPLPTAASPA----- 599
                :..:.|.| .:...::|..:.:......:| ||...|.|      |.....:.|.|
  Rat   451 VTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGK 515

  Fly   600 PSNCSSTSSRVGRHSLSSS------SPRSH 623
            ||..|.|||..   ||.||      .|.||
  Rat   516 PSEVSLTSSVT---SLDSSPVDVAPRPGSH 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	120/252 (48%)
		UBA_SIK	418..458	CDD:270523	9/42 (21%)
Prkaa1	NP_062015.2	STKc_AMPK_alpha	24..279	CDD:270981	121/254 (48%)
		UBA_AID_AAPK1	296..360	CDD:270586	14/69 (20%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	302..381		17/89 (19%)
		AMPKA1_C	404..557	CDD:213384	31/144 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	484..536		18/54 (33%)