DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik2 and Gm6902

DIOPT Version :10

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_001257423.1 Gene:Gm6902 / 628664 MGIID:3647238 Length:301 Species:Mus musculus


Alignment Length:270 Identity:117/270 - (43%)
Similarity:167/270 - (61%) Gaps:13/270 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 LKLKEPMRVGFYDIE----------RTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK 184
            ||:.|......|.||          .|:|:|.|:|||.|.|..|...||:||:..:: :.|:  .
Mouse     6 LKMMEQDLKACYSIEENFDTNYKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNTK-EYTS--P 67

  Fly   185 VYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIIS 249
            :.||..|||.|.||:||||:.|::.:...|:|.||||:||:.|.|.|.|.:.||..|..|.||:.
Mouse    68 ICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELQDRIIKVGSLEESETRRLFAQIVH 132

  Fly   250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314
            ||:|||...|||||:||.|:|:|...|.|:.|||.:....||:.||.:||:.||.|||:.:.::|
Mouse   133 AVQYCHDHHIVHRDIKASNILIDYRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKY 197

  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379
            .||.:|||||||:|:::|.|.|||.|.....|:..::|..|.||..:|.:..::|..:|::.|:|
Mouse   198 EGPPVDIWSLGVLLFLMVSGNLPFQGRYFVDLKQEIISANFSIPSHVSIDILNVIIELLMINPSR 262

  Fly   380 RYTIDQIKRH 389
            |.||.||.||
Mouse   263 RPTIHQIMRH 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 114/260 (44%)
UBA_SIK 418..458 CDD:270523
Gm6902NP_001257423.1 STKc_AMPK-like 26..273 CDD:270905 111/250 (44%)
Blue background indicates that the domain is not in the aligned region.

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