Protein Alignment Sik2 and Sik1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_067725.2
• Gene: Sik1 / 59329
• RGDID: 69407
• Length: 776
• Species: Rattus norvegicus
• Alignment Length: 932
• Identity: 347/932 - (37%)
• Similarity: 458/932 - (49%)
• Gaps: 219/932 - (23%)

  Fly   117 SAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTN 181
            |||..|...|:     ::|:||||||:|||:||||||||||||||:||.:||||||||::||.:|
  Rat     8 SAVPTGTGQGQ-----QKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSN 67

  Fly   182 LQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQ 246
            |:|:||||::||.|.||:|||||||||||:|:|||:|:|..||:|||:...|.:||:.||.||||
  Rat    68 LEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQ 132

  Fly   247 IISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEG 311
            |:|||||||...|||||||.||||||.||:||:|||||.|.:||||.|:||||||||||||||||
  Rat   133 ILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEG 197

  Fly   312 KQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLE 376
            |:|.||::|||||||||||||||:|||||..|.:||.|||.||||||||||.:||.|||||||::
  Rat   198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVD 262

  Fly   377 PTRRYTIDQIKRHRWM--CPELLEH----VLIAKY--NLGAERQTSVEPSEDILRIMAEYVGIGS 433
            |.:|.||.||::||||  .|.||:.    ..:..|  |||       :.:|.:|.|| :.:||..
  Rat   263 PAKRITIAQIRQHRWMQADPTLLQQDDPAFSMQGYTSNLG-------DYNEQVLGIM-QALGIDR 319

  Fly   434 DKTRASLKKNTYDHVAAIYLLLQDRV-SHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQ 497
            .:|..||:.::|:|.||||.||.:|: .|:..|.                   |||....|.:|.
  Rat   320 QRTVESLQNSSYNHFAAIYYLLLERLREHRSTQP-------------------SSRATPAPARQP 365

  Fly   498 SQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLT 562
            ..:.|...|             |...|.:|..:     ...|::..|.|...|: ..||..:...
  Rat   366 QLRNSDLSS-------------LEVPQEILPCD-----PFRPSLLCPQPQALAQ-SVLQAEIDCD 411

  Fly   563 GHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVA 627
            .||.|.               ||   :.||.|       |||.    |.||  .|.||.|....|
  Rat   412 LHSSLQ---------------PL---FFPLDT-------NCSG----VFRH--RSISPSSLLDTA 445

  Fly   628 ISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAV 692
            ||......|||...  :|:.|...|..|.          ..|::|.....|..:...::..|:|.
  Rat   446 ISEEARQGPSLEEE--QEVQEPLPGSTGR----------RHTLAEVSTHFSPLNPPCIIVSSSAA 498

  Fly   693 AEGKDDPPKAESSVGGVPPPASTTPTSSTAGPE--SGSAPCPGEINGKT--------IKTMSSSS 747
            .    .|.:..||       .|..|.|::.||.  .|....||.:...:        :.:.|::.
  Rat   499 V----SPSEGTSS-------DSCLPFSASEGPAGLGGGLATPGLLGTSSPVRLASPFLGSQSATP 552

  Fly   748 SFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNG 812
            ...|:|.||.:....:|.                 |..:|......|.|......|...:|::.|
  Rat   553 VLQSQAGLGATVLPPVSF-----------------QEGRRASDTSLTQGLKAFRQQLRKNARTKG 600

  Fly   813 DSRSEK-KVLAQGSSSTDEGCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDLTRLVGT 876
            .....| |.||:      :.|::           ..:||.||.|       |.|:.:..:.|.|.
  Rat   601 FLGLNKIKGLAR------QVCQS-----------SIRGSRGGMS-------TFHTPAPSSGLQGC 641

  Fly   877 TTS---GQS------HKMR----SYASSSSSSGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDS 928
            |.|   |:|      |:.|    .:.|:.||....|.........|:              |.|.
  Rat   642 TASSREGRSLLEEVLHQQRLLQLQHHSAVSSDYQQAPQLSPVPYVLT--------------PCDG 692

  Fly   929 LDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISSEHSSERSLYGSHNSCIHM---PGALPLG 990
            |   |.||...||:.:....|         ||.      :|...|..:|   :|:   |.|||.|
  Rat   693 L---LVSGIPLLPTPLLQPGM---------SPV------ASAAQLLDAH---LHISAGPVALPTG 736

  Fly   991 LGLPQS-SASTPTPNPTPPPNG 1011
             .|||. :..:|:.:|...|.|
  Rat   737 -PLPQCLTRLSPSCDPAGLPQG 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	184/251 (73%)
		UBA_SIK	418..458	CDD:270523	17/39 (44%)
Sik1	NP_067725.2	STKc_SIK	26..278	CDD:270973	184/251 (73%)
		UBA_SIK1	300..349	CDD:270591	21/56 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..371		6/39 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		6/24 (25%)
		RK-rich region. /evidence=ECO:0000250	586..612		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..643		9/28 (32%)