DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik2 and mark4b

DIOPT Version :9

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:XP_005157655.1 Gene:mark4b / 571279 ZFINID:ZDB-GENE-100330-2 Length:796 Species:Danio rerio


Alignment Length:1046 Identity:317/1046 - (30%)
Similarity:441/1046 - (42%) Gaps:317/1046 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 QPQHERNEKQLDKPPENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGAASPSIDA-----IV 90
            ||.::||                        |..|..|.|.||.  ..:|.:|.|:.|     |.
Zfish     8 QPGNDRN------------------------ADHHATLSASRSE--KGSGWSSRSLGARCRNSIA 46

  Fly    91 ACKDALLAQKLFASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVV 155
            :|.|                                       |...:|.|.:.:||||||||.|
Zfish    47 SCSD---------------------------------------EQPHIGNYRLLKTIGKGNFAKV 72

  Fly   156 KLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYA 220
            |||||.:|..|||||||||:||:.|:|||::|||.|||.|.||:|::|::|:||:..:|:|.|||
Zfish    73 KLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKGLNHPNIVQLFEVIETEKTLYLVMEYA 137

  Fly   221 SQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFS 285
            |.||:|||:..:|||.|..||.||.||:|||.|||.|.||||||||||||||.:.||||||||||
Zfish   138 SGGEVFDYLVSHGRMKEKEARGKFRQIVSAVHYCHLKNIVHRDLKAENLLLDADSNIKIADFGFS 202

  Fly   286 NHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRV 350
            |.|..|..|.|:||||||||||:|:||:|.|||:|||||||:||.||.|:|||||..|:.||:||
Zfish   203 NEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGQNLKELRERV 267

  Fly   351 LSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAER---Q 412
            |.|::|:||:||::||.::||.|||.||:|.|::||.:.:||             |:|.|.   :
Zfish   268 LRGKYRVPFYMSTDCEGILRRFLVLNPTKRCTLEQIMKDKWM-------------NVGYENDELK 319

  Fly   413 TSVEPSEDI-----LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLL----QDRVSHKKEQS 466
            ..:||.||.     :.:|   ||:|  .|:.:.:|....|:.:.|.||||    :|.:..:...|
Zfish   320 PYIEPVEDYNDTSRVDVM---VGMGYSRDEIKDALTTQKYNEIFATYLLLGRKNEDGMESRSSSS 381

  Fly   467 NGLG---ASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLM 528
            ..|.   .||:.:.||                    :.|.|.|:||..|..  |.:..|..:...
Zfish   382 LSLARVRPSAITNGTS--------------------KHSSTSSSSSTSASS--HTKPQRSASTYH 424

  Fly   529 SERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLP 593
            .:|.......|:||...|    |..|..           ||       |.|.....||.|.|   
Zfish   425 RQRRHSDFCGPSVPVAHP----KRSPTS-----------TG-------EGDLKEERLPSRKT--- 464

  Fly   594 TAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVG 658
                        :||.||..|:..|||        .:|..|||:.:.                  
Zfish   465 ------------SSSVVGSRSIPPSSP--------MVSTANNPNKSE------------------ 491

  Fly   659 VPLASKQLHQTISEF----IIKQSTEDC--RALLQQSTAVAEGKDDPPKAESSVGGVPPPAS-TT 716
            :|...|.::.|.:..    :.:::|..|  |....:.:.:..||::     ||:....|||| :|
Zfish   492 IPDRRKDINATTNNIPASAMTRRNTYVCTDRTGTDRHSLLQNGKEN-----SSLSHRLPPASPST 551

  Fly   717 PTSSTAGPESGSAPCPGEI-NGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTL--QESP 778
            .:.|.||..|.::.....: .|.||:     |:|..    ||...::....|.....||  :.||
Zfish   552 HSISGAGASSSTSSERSRLTRGSTIR-----STFHG----GQLREHRPPTHAPPTSPTLSHEASP 607

  Fly   779 LP-------------VEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDE 830
            ||             :..:..|||::..:.                          .|.|:.:..
Zfish   608 LPHSRSRATTNLFTKLTSKLTRRVNLDPSK--------------------------RQSSNKSVS 646

  Fly   831 GCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDL-TRLVGTTTSGQSHKMRSYASSSSS 894
            ||...|                 ||...........|:|| ::...|.|..|:.|...|.|    
Zfish   647 GCTLPQ-----------------GSKTVRSQTNLRESADLRSQATDTATKSQAKKHSRYLS---- 690

  Fly   895 SGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASAS 959
                     .|.|:......|.........|.|..:..|...:    :..|....:     ..|.
Zfish   691 ---------GYQKATEPRTPRCGWDVRVRSPRDPAEVVLALRE----AAQGCGCQV-----HQAG 737

  Fly   960 PAGISSEHSSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKR---S 1021
            |..:|..|.:..|..........:|..                     |....||.|  ||   :
Zfish   738 PFLLSCTHGAAGSRVAFEAEVCQLPNG---------------------PTESSGVRF--KRLWGA 779

  Fly  1022 PIHFRE 1027
            |:.||:
Zfish   780 PLAFRD 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 161/251 (64%)
S_TKc 141..392 CDD:214567 161/250 (64%)
mark4bXP_005157655.1 STKc_MARK 57..309 CDD:270974 161/251 (64%)
S_TKc 58..309 CDD:214567 161/250 (64%)
UBA_like_SF 327..369 CDD:304366 13/44 (30%)
MARK4_C 699..796 CDD:213382 20/119 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000311
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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