Protein Alignment Sik2 and mark4b

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_005157655.1
• Gene: mark4b / 571279
• ZFINID: ZDB-GENE-100330-2
• Length: 796
• Species: Danio rerio
• Alignment Length: 1046
• Identity: 317/1046 - (30%)
• Similarity: 441/1046 - (42%)
• Gaps: 317/1046 - (30%)

  Fly    31 QPQHERNEKQLDKPPENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGAASPSIDA-----IV 90
            ||.::||                        |..|..|.|.||.  ..:|.:|.|:.|     |.
Zfish     8 QPGNDRN------------------------ADHHATLSASRSE--KGSGWSSRSLGARCRNSIA 46

  Fly    91 ACKDALLAQKLFASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVV 155
            :|.|                                       |...:|.|.:.:||||||||.|
Zfish    47 SCSD---------------------------------------EQPHIGNYRLLKTIGKGNFAKV 72

  Fly   156 KLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYA 220
            |||||.:|..|||||||||:||:.|:|||::|||.|||.|.||:|::|::|:||:..:|:|.|||
Zfish    73 KLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKGLNHPNIVQLFEVIETEKTLYLVMEYA 137

  Fly   221 SQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFS 285
            |.||:|||:..:|||.|..||.||.||:|||.|||.|.||||||||||||||.:.||||||||||
Zfish   138 SGGEVFDYLVSHGRMKEKEARGKFRQIVSAVHYCHLKNIVHRDLKAENLLLDADSNIKIADFGFS 202

  Fly   286 NHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRV 350
            |.|..|..|.|:||||||||||:|:||:|.|||:|||||||:||.||.|:|||||..|:.||:||
Zfish   203 NEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGQNLKELRERV 267

  Fly   351 LSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAER---Q 412
            |.|::|:||:||::||.::||.|||.||:|.|::||.:.:||             |:|.|.   :
Zfish   268 LRGKYRVPFYMSTDCEGILRRFLVLNPTKRCTLEQIMKDKWM-------------NVGYENDELK 319

  Fly   413 TSVEPSEDI-----LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLL----QDRVSHKKEQS 466
            ..:||.||.     :.:|   ||:|  .|:.:.:|....|:.:.|.||||    :|.:..:...|
Zfish   320 PYIEPVEDYNDTSRVDVM---VGMGYSRDEIKDALTTQKYNEIFATYLLLGRKNEDGMESRSSSS 381

  Fly   467 NGLG---ASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLM 528
            ..|.   .||:.:.||                    :.|.|.|:||..|..  |.:..|..:...
Zfish   382 LSLARVRPSAITNGTS--------------------KHSSTSSSSSTSASS--HTKPQRSASTYH 424

  Fly   529 SERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLP 593
            .:|.......|:||...|    |..|..           ||       |.|.....||.|.|
Zfish   425 RQRRHSDFCGPSVPVAHP----KRSPTS-----------TG-------EGDLKEERLPSRKT--- 464

  Fly   594 TAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVG 658
                        :||.||..|:..|||        .:|..|||:.:.
Zfish   465 ------------SSSVVGSRSIPPSSP--------MVSTANNPNKSE------------------ 491

  Fly   659 VPLASKQLHQTISEF----IIKQSTEDC--RALLQQSTAVAEGKDDPPKAESSVGGVPPPAS-TT 716
            :|...|.::.|.:..    :.:::|..|  |....:.:.:..||::     ||:....|||| :|
Zfish   492 IPDRRKDINATTNNIPASAMTRRNTYVCTDRTGTDRHSLLQNGKEN-----SSLSHRLPPASPST 551

  Fly   717 PTSSTAGPESGSAPCPGEI-NGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTL--QESP 778
            .:.|.||..|.::.....: .|.||:     |:|..    ||...::....|.....||  :.||
Zfish   552 HSISGAGASSSTSSERSRLTRGSTIR-----STFHG----GQLREHRPPTHAPPTSPTLSHEASP 607

  Fly   779 LP-------------VEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDE 830
            ||             :..:..|||::..:.                          .|.|:.:..
Zfish   608 LPHSRSRATTNLFTKLTSKLTRRVNLDPSK--------------------------RQSSNKSVS 646

  Fly   831 GCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDL-TRLVGTTTSGQSHKMRSYASSSSS 894
            ||...|                 ||...........|:|| ::...|.|..|:.|...|.|
Zfish   647 GCTLPQ-----------------GSKTVRSQTNLRESADLRSQATDTATKSQAKKHSRYLS---- 690

  Fly   895 SGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASAS 959
                     .|.|:......|.........|.|..:..|...:    :..|....:     ..|.
Zfish   691 ---------GYQKATEPRTPRCGWDVRVRSPRDPAEVVLALRE----AAQGCGCQV-----HQAG 737

  Fly   960 PAGISSEHSSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKR---S 1021
            |..:|..|.:..|..........:|..                     |....||.|  ||   :
Zfish   738 PFLLSCTHGAAGSRVAFEAEVCQLPNG---------------------PTESSGVRF--KRLWGA 779

  Fly  1022 PIHFRE 1027
            |:.||:
Zfish   780 PLAFRD 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	161/251 (64%)
		UBA_SIK	418..458	CDD:270523	14/50 (28%)
mark4b	XP_005157655.1	STKc_MARK	57..309	CDD:270974	161/251 (64%)
		UBA_like_SF	327..369	CDD:473871	13/44 (30%)
		MARK4_C	699..796	CDD:213382	20/119 (17%)