DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and sik2b

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_696325.5	Gene:	sik2b / 567919	ZFINID:	ZDB-GENE-071012-1	Length:	896	Species:	Danio rerio

Alignment Length:	1317	Identity:	406/1317 - (30%)
Similarity:	536/1317 - (40%)	Gaps:	493/1317 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLK 196
            |:.|:||||||||||:|||||||||||||||||.|||||||||:|||..||:|:||||:|||.|.
Zfish    13 LRGPVRVGFYDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLD 77

  Fly   197 HPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVH 261
            ||||||||||||||||:|:|:|||..||||||:||:||:||..||.|||||:|||||||.:.|||
Zfish    78 HPHIIKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNIVH 142

  Fly   262 RDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGV 326
            |||||||||||.:||||||||||.|.|:.|:.||||||||||||||||||:||.||::||||:||
Zfish   143 RDLKAENLLLDGHMNIKIADFGFGNFFQSGKPLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGV 207

  Fly   327 VLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRW 391
            ||||||||||||||.:|..||.|||.||||||:||:.:|||||||||||:|::|.:|.|||.|:|
Zfish   208 VLYVLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKRLSIGQIKEHKW 272

  Fly   392 MCPEL-LEHVLIAKYNLGAERQTSV-EPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLL 454
            |..|: ::..::  |....|.:..| |.:|.:||:| ..:||...||..||:..:|:|.||||.|
Zfish   273 MVMEVPVQRPML--YQQTTEGEAGVGEYNEQVLRLM-HSLGIDQHKTVESLQNKSYNHFAAIYYL 334

  Fly   455 LQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKR 519
            |.:|:                   .|.|..:..    :|.....|::..||:..:::      |.
Zfish   335 LVERL-------------------KAHRCSFPV----EPRLDARQRRPSTIAEQTLV------KA 370

  Fly   520 LSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIP 584
            .|....|.:..:|......|.||                                  :..|....
Zfish   371 SSAAPQVSLLPQNVRLLRPPAVP----------------------------------QTSADSFT 401

  Fly   585 LPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEA 649
            .|.             |:|::      .|||                               ||
Zfish   402 FPQ-------------SSCAA------EHSL-------------------------------ME- 415

  Fly   650 GGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPAS 714
                                                                 |..||
Zfish   416 -----------------------------------------------------EEEVG------- 420

  Fly   715 TTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPL 779
             ||                :|||..:                                    .||
Zfish   421 -TP----------------KINGCML------------------------------------DPL 432

  Fly   780 PVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSAS 844
            |       .|.|..::.|...:..||                     |.|||.||:   :|.:..
Zfish   433 P-------PVAVRKSSASSPSNMMET---------------------SIDEGIETE---EPDTED 466

  Fly   845 QESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSL 909
            ..:...|  ....|..|...|:.|::|...|..|||               |.|.        |:
Zfish   467 DHTHVFN--AYQTARFGQRRHTLSEVTNQPGIITSG---------------GKLF--------SM 506

  Fly   910 SQNLSRGSSKSNCSGPYD----SLDFALPSGKGSLPSCMGSSSMLATPTP--ASASPAGISSEH- 967
            ..|.|.||..|.    ||    ..|.:|.....||...:.:::.:...||  .||.||..:.:.
Zfish   507 GHNPSLGSVDSE----YDMGSMHSDLSLLEDGPSLNEVVLANTPVTRLTPPFISARPANPTMQAL 567

  Fly   968 SSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRAS 1032
            |::|.  .:||                                         ||||.||||||||
Zfish   568 STQRR--ETHN-----------------------------------------RSPISFREGRRAS 589

  Fly  1033 DGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQHPH 1097
            |..:.|||::          :..:....|:..|.||   |.::..:...|.:.......|..|||
Zfish   590 DTSLTQGLVA----------FRQHLQNLARTKGILE---LNKVYAQMGSGETPSLGLLSPQAHPH 641

  Fly  1098 PHPQAYG-LEELCQFPNGQFYALPGKHHPLLTLPHHHAHPA----------QHHHGHHSLFHSGH 1151
                  | |:...|...|        |.|.:.|.....|||          |:      |.|...
Zfish   642 ------GLLDPALQEERG--------HQPDIALCSGGTHPALLSRRQSLEPQY------LPHRIQ 686

  Fly  1152 QATPLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQLLQHRLLQQK 1216
            :|| |:..:.:...|:   |...|                         ..|:|||.:|| ||||
Zfish   687 KAT-LMANSPSSCQMF---CKETP-------------------------RSLEQQLQEHR-LQQK 721

  Fly  1217 RQLFQKQYALEAQLAGRHHHHQQHSHHHHH----HFGH-SLGPPPPP--APAPEHHLADELYELA 1274
            |...|||..::|      :.:|.|......    ..|| ..|.||.|  :.||.|
Zfish   722 RLYLQKQTQMQA------YFNQMHIVEDPFAPCATMGHQDSGAPPQPQGSLAPAH---------- 770

  Fly  1275 LLDRPRSGTPRLQHSMTM-------PGAHAFS-------QMN-LKTSYISQSDQVPGAAPNGAGS 1324
              .:|:| :|...|:..:       |.|.|:.       |:. |..||.:|..|
Zfish   771 --QQPQS-SPPFAHAQPLGPLMEPNPEALAYETYLGLYPQLQPLPQSYPAQLQQ----------- 821

  Fly  1325 GGSAAGVSCSAPPSTAPGTPTVKCKPT-TPHGHSL---DSDYHTS----TPVLSLFTPNWQSLV- 1380
               ...::.:.||          |.|: :|.|.:|   ..||...    .|...:.|..::.|.
Zfish   822 ---PEPLNYTYPP----------CDPSHSPSGEALYPEQYDYPLDPGQLPPPAEVSTAGYEGLAL 873

  Fly  1381 -KPLSESPILEI--SEH 1394
             .|..:|.::|.  |:|
Zfish   874 GDPFLDSEMMETVDSQH 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	195/251 (78%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	194/250 (78%)
sik2b	XP_696325.5	STKc_SIK	21..273	CDD:270973	195/251 (78%)
		S_TKc	22..273	CDD:214567	194/250 (78%)
		UBA_SIK2	299..343	CDD:270592	20/63 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594923
Domainoid	1	1.000	420	1.000	Domainoid score	I618
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1304
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm25977
orthoMCL	1	0.900	-	-		OOG6_105552
Panther	1	1.100	-	-	O	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5859
SonicParanoid	1	1.000	-	-		X2250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780