Protein Alignment Sik2 and brsk1a

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_073774214.1
• Gene: brsk1a / 564701
• ZFINID: ZDB-GENE-121214-354
• Length: 844
• Species: Danio rerio
• Alignment Length: 1009
• Identity: 266/1009 - (26%)
• Similarity: 403/1009 - (39%)
• Gaps: 266/1009 - (26%)

  Fly   127 KDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEI 191
            |:|...:....||.|.:|:|:|||...:|||..|.||..:|||||:::.:|.::.|.||.||:.|
Zfish     3 KELSVTQAAQYVGPYRLEKTLGKGQTGLVKLGIHCITSQKVAIKIVNREKLSESVLMKVEREIAI 67

  Fly   192 MKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHK 256
            :|.::|||::||:.|.|....:|:|.|:.|.||:|||:.|.||::...||..|.|||||:::||.
Zfish    68 LKLIEHPHVLKLHDVYENNKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHS 132

  Fly   257 KGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDI 321
            ..|.|||||.||||||...||:|||||.::......||.|.||||.||.|||..|::|.|...|:
Zfish   133 HSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRRADV 197

  Fly   322 WSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQI 386
            ||.||:|:.|:.||||||...|:.|.::|.||.|.:|.|:..:|:.|:|.|:.:.|.:|.|::.|
Zfish   198 WSCGVILFALLVGALPFDHDNLRQLLEKVKSGVFHMPHFIPPDCQALLRGMIEVNPEKRLTLEAI 262

  Fly   387 KRHRWM-------CP-----------------ELLEHVLIAKYNLGAERQTSVEPSEDILRIMAE 427
            ::|.|.       ||                 ||...||.:.|:||..|. .|:.::|:
Zfish   263 QKHAWYQAGRNEPCPEQPPPRRVSMGRIMSLTELDPDVLDSMYSLGCFRD-RVKLAQDL------ 320

  Fly   428 YVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQ 492
                       ..:::..:.:  ||.||.||    ||:                   |.|..|..
Zfish   321 -----------QCEEDNQEKM--IYYLLLDR----KER-------------------YPSYEDED 349

  Fly   493 -PTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQ 556
             |.:.......|.:.:..:....:|.......:.:.::|:     .:||.|             :
Zfish   350 LPPRNDVDPPRKRVDSPMLTRHGRCRPERKSLEVLSVTEQ-----GSPTPP-------------R 396

  Fly   557 LPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPA-----PSNCSSTSSRVGRHSLS 616
            ..|..:.||..:..::|....:.:|         ||.:..||.     |...::|.:..|  |.:
Zfish   397 RALDTSTHSQRSRSVSGASTGLSSS---------PLSSPRSPVFTFSEPEVVAATKATSG--STN 450

  Fly   617 SSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQ--------LHQTISEF 673
            |...|||.|...:|...|.|....|:..:            .:||.|..        |...|..|
Zfish   451 SRPNRSHEPKTQTLPSKNAPERPQLQSMK------------SLPLPSSSSRSPSPSPLLSPIPRF 503

  Fly   674 --------IIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAP 730
                    ::|..|   ::|...|....:|...|....:.|....||.:|.|:||:
Zfish   504 LFFPSPSAVLKSVT---KSLYPMSQVTPQGSPLPTPLGTPVHHPHPPTATPPSSSS--------- 556

  Fly   731 CPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTN 795
                         |||||......:|          ...|..|...||                .
Zfish   557 -------------SSSSSRAEGGGVG----------VGSLSLTPPSSP----------------G 582

  Fly   796 GSGGDSGQET-------NDAKSN--GDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQESKGSN 851
            |.||.:...:       |..|:|  |..|..::.| |..:|.|....|     |.|:.:.:|.|
Zfish   583 GGGGMAASSSAHWRTRLNSLKNNLLGSPRFHRRKL-QVPTSEDMSSLT-----PESSPELAKRS- 640

  Fly   852 GGGSGN-------------ANGGPTSHSSSDLTRLVGTTTSGQSHKM---RSYASSSSSSG---- 896
              ..||             ....|.|...:|:.....:..| .||.:   .|:.:...:||
Zfish   641 --WFGNFISLEKEEQIFVVIRDKPLSSIKADIVHAFLSIPS-LSHSVISQTSFRAEYKTSGGPSV 702

  Fly   897 ---------VLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLAT 952
                     .::.|.|...:...:...|...|.  .|.| |:.|:|.||    ||       ...
Zfish   703 FQKPVKFQVDISFSEGERERERERERDRDGQKD--FGIY-SVTFSLISG----PS-------RRF 753

  Fly   953 PTPASASPAGISSEHSSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPP----PNGGG 1013
            ........|.:.|.|  ::::..:.::|:         ...|....|.|...||..    ..|||
Zfish   754 RRVVETIQAQLLSAH--DQTMVQTFSACL---------CSSPDEKNSRPPRTPTRQNSRRSEGGG 807

  Fly  1014 VTFLDKRSPIHFREG----RRASDGLVAQGLLSS 1043
                |:...:...||    :|...|.....||||
Zfish   808 ----DRCEWVERGEGGVLLQRRGSGKERTRLLSS 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	118/251 (47%)
		UBA_SIK	418..458	CDD:270523	5/39 (13%)
brsk1a	XP_073774214.1	None