Protein Alignment Sik2 and PRKAA2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_006243.2
• Gene: PRKAA2 / 5563
• HGNCID: 9377
• Length: 552
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 189/597 - (31%)
• Similarity: 282/597 - (47%)
• Gaps: 106/597 - (17%)

  Fly   136 MRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTN-LQKVYREVEIMKRLKHPH 199
            :::|.|.:..|:|.|.|..||:..|::|.::||:||:::.::...: :.|:.||::.:|..:|||
Human    11 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPH 75

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||:.|....::|.||.|.||:||||.|:||:.|..||..|.||:|||:|||:..:|||||
Human    76 IIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDL 140

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            |.||:|||.:||.||||||.||....||.|.|.||||.||||||..|:.|.|||:||||.||:||
Human   141 KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILY 205

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            .|:||.||||...:.:|..::..|.|.||.:::.....|:..||.::|.:|.||..|:.|.|...
Human   206 ALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQ 270

  Fly   395 ELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDK---TRASLKKNTY-----DHVAAI 451
            :|..::.            ..:||.|...|..|.|....:|   |.:.:..:.|     |.:|..
Human   271 DLPSYLF------------PEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVA 323

  Fly   452 YLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQC 516
            |.|:.|    .:...|......||||..:...:..|.....|..:...::...:...|  .|.:|
Human   324 YHLIID----NRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADS--PKARC 382

  Fly   517 ---HKRLSRHQTVLMSERNAHAG-ATPTVP-------------------------------DPGP 546
               ....::.:::.:.:...|.| .:.:.|                               :|..
Human   383 PLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVT 447

  Fly   547 GYYAKYGPLQLPLPLTGHSHLTGY--LNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSR 609
            |.|.|.. |||.| :...|:|..:  ::...|| ..||...|.|             :||:....
Human   448 GNYVKMS-LQLYL-VDNRSYLLDFKSIDDEVVE-QRSGSSTPQR-------------SCSAAGLH 496

  Fly   610 VGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFI 674
            ..|.|..|::..||     |||.....||.           |..:.:|...|.|    .|:..|
Human   497 RPRSSFDSTTAESH-----SLSGSLTGSLT-----------GSTLSSVSPRLGS----HTMDFF- 540

  Fly   675 IKQSTEDCRALL 686
                 |.|.:|:
Human   541 -----EMCASLI 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	122/252 (48%)
		UBA_SIK	418..458	CDD:270523	12/47 (26%)
PRKAA2	NP_006243.2	STKc_AMPK_alpha	13..268	CDD:270981	123/254 (48%)
		UBA_AID_AAPK2	285..349	CDD:270587	16/67 (24%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376		17/88 (19%)
		AMPKA2_C	395..550	CDD:213385	40/195 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..521		17/62 (27%)