DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and sik1

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001119855.1	Gene:	sik1 / 553465	ZFINID:	ZDB-GENE-030131-9446	Length:	811	Species:	Danio rerio

Alignment Length:	737	Identity:	292/737 - (39%)
Similarity:	390/737 - (52%)	Gaps:	174/737 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKN-----------EVAIKIIDKSQLDQTNLQKVYRE 188
            |::||||:|.||:|||||||||||||::||.           :||||||||::|:..||:|:|||
Zfish    20 PLQVGFYEIIRTLGKGNFAVVKLARHKVTKTQAITTFYFIFMQVAIKIIDKTRLNSANLEKIYRE 84

  Fly   189 VEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEY 253
            |:|||.|.||||||||||||||:|:|||:|||..||:|||:...|||||:.||.|||||::||:|
Zfish    85 VQIMKLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDYLTSNGRMSENEARKKFWQILTAVDY 149

  Fly   254 CHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPE 318
            ||:..|||||||.||||||.|||||:|||||.|.:..||.|:|||||||||||||||||:|.||:
Zfish   150 CHRHHIVHRDLKTENLLLDANMNIKLADFGFGNFYNAGEPLSTWCGSPPYAAPEVFEGKEYEGPQ 214

  Fly   319 IDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTI 383
            :|||||||||||||||:|||||.:|.:||.||..||||||||||.:||:|||:|||::|.:|.||
Zfish   215 LDIWSLGVVLYVLVCGSLPFDGDSLPALRQRVTEGRFRIPFFMSQDCENLIRKMLVVDPAKRITI 279

  Fly   384 DQIKRHRWM-----CPELLEHVLIAKY--NLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLK 441
            .|||:||||     .|.....:.:..|  |||       :.||.:|.|| :.:||...:|..||:
Zfish   280 AQIKQHRWMLADPSAPHQTLSLSLTDYNSNLG-------DYSEPVLGIM-QTLGIDRQRTVESLQ 336

  Fly   442 KNTYDHVAAIYLLLQDRV-SHKKEQ-SNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKT 504
            .::|:|.:|||.||.:|| .|:.:| |...||                          ..|:|:|
Zfish   337 NSSYNHFSAIYYLLLERVKEHRSQQISRQCGA--------------------------WNQRSRT 375

  Fly   505 ISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTG 569
            .|.|            |..:.::.|..:....|.|..             .::..|:  ||.:.
Zfish   376 ASDS------------STPEVIMESSDSFRNSAFPVA-------------TKVNAPI--HSEME- 412

  Fly   570 YLNGGG--------VEVDASGI-------PLPMRYTPLPTAASP------------APSNCSSTS 607
             ...||        ||...:|:       |..:..|.:.....|            .|.:..||:
Zfish   413 -CEQGGLFQRVVCPVEASLNGLLWNRSISPNSLLETTISEEVRPHDLEEEEGILQVQPPHLPSTT 476

  Fly   608 SRVGRHSLSS-SSPRSHR--PVAISL--------------SIDNNPSLANL--RCREMMEAGGGP 653
            ||  ||:|:. |:.|.|:  |..|.:              |.:.||.|:.:  ....::.:|.||
Zfish   477 SR--RHTLAEVSTSRFHQCSPPCIVVSPSDGASSDSCLKSSSNTNPPLSPVVGDFSSLLISGTGP 539

  Fly   654 --VGAVGVPL----------------ASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPP 700
              :|..|.||                ||.|..:..|:..:.|..:..|..|:::|. |:|.....
Zfish   540 GALGPAGTPLALSSNLLLQNQGSMLAASFQEGRRASDTSLTQGLKAFRQQLRKNTR-AKGLLGLN 603

  Fly   701 KAESSVGGVPPPASTTPTS-STAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMS 764
            |.:.....|.||:|.:..| .:.||                 ||...||..|.:  |...|..|.
Zfish   604 KIKGLARQVCPPSSCSRGSRGSLGP-----------------TMCPPSSLQSSS--GPRERRSML 649

  Fly   765 AEA---SKLFQTLQESPLPVEQ 783
            .|.   .::.| :|..|.|..|
Zfish   650 EEVLHQQRMLQ-IQHQPQPQVQ 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	182/262 (69%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	181/261 (69%)
sik1	NP_001119855.1	STKc_SIK	25..288	CDD:270973	182/262 (69%)
		S_TKc	26..288	CDD:214567	181/261 (69%)
		UBA_SIK1	309..358	CDD:270591	22/56 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I618
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	1	1.000	-	-		otm25977
orthoMCL	1	0.900	-	-		OOG6_105552
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2250
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.770