Protein Alignment Sik2 and Gm5891

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001030076.1
• Gene: Gm5891 / 545929
• MGIID: 3649014
• Length: 313
• Species: Mus musculus
• Alignment Length: 314
• Identity: 124/314 - (39%)
• Similarity: 179/314 - (57%)
• Gaps: 35/314 - (11%)

  Fly   130 LKLKEPMRVGFYDIE----------RTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQK 184
            ||:.|......|.||          .|:|:|||:|||.|.|..|...||:||:..:: :.|:  .
Mouse    13 LKMMEQDLKACYSIEENFDINYKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNTK-EYTS--P 74

  Fly   185 VYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIIS 249
            :.||..|||.|.||:||||:.|::.:...|:|.||||:||:.|.|.....:.||..|..|.||:.
Mouse    75 ICREARIMKSLSHPNIIKLFHVVQRRETTYLVMEYASEGELLDRIINVVSLEESETRRLFAQIVH 139

  Fly   250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314
            ||:|||...|||||:||.|:|:|...|.|:.|||.:....||:.||.:||:.||.|||:.:.::|
Mouse   140 AVQYCHDHHIVHRDIKASNILIDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKY 204

  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379
            .|..:|||||||:|:::|.|.|||.|.:...|:..::|..|.||..:|.:..::|..:|::.|:|
Mouse   205 EGLPVDIWSLGVLLFLMVSGNLPFQGRSFVDLKQEIISANFSIPSHVSIDISNVIIELLMINPSR 269

  Fly   380 RYTIDQIKRHRWMCPELLEHVLIAKYNLGAER---QTSVE-----PSEDILRIM 425
            |.||.||.||..:              .|:|.   .||.:     ||..|:|.|
Mouse   270 RPTIHQIMRHPMI--------------RGSEACLPPTSTQTFPGTPSHSIVRTM 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	112/261 (43%)
		UBA_SIK	418..458	CDD:270523	4/8 (50%)
Gm5891	NP_001030076.1	STKc_AMPK-like	33..280	CDD:270905	108/249 (43%)