DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and Smok3a

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001119517.1	Gene:	Smok3a / 545814	MGIID:	3693943	Length:	504	Species:	Mus musculus

Alignment Length:	456	Identity:	138/456 - (30%)
Similarity:	229/456 - (50%)	Gaps:	58/456 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 VGAGGISGKDLLKLKEPMR-----VGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLD 178
            :|.|.....:.|:.|.|:.     ...|.:..|||.|..|.||||:||:|...||:|.|.|.:.
Mouse     1 MGPGSQQKSEKLRSKSPLADMDGLHAQYVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREY- 64

  Fly   179 QTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFK 243
              ...:|..|||::....||:||.|.||:|||..:|::.|......::.:|.|.|.:.|..||..
Mouse    65 --WCNRVISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARAL 127

  Fly   244 FWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEV 308
            |.|::||:.|||.:||||||||.:|::::.:..:||.|||.....|||:.|..:||:.|::||||
Mouse   128 FKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEV 192

  Fly   309 FEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRML 373
            .....|.||:||:|:||||||.:|.|.:|||..:::.|..|:|:|::.||..:|:|.:.|:..::
Mouse   193 LLSTPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLM 257

  Fly   374 VLEPTRRYTIDQIKRHRWMC------PELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIG 432
            ...|..|.|:.::..|.|:.      |:            ..|.||.::|...|::.|. ::|..
Mouse   258 TANPKLRPTVAEVMVHPWVTEGSGVFPD------------PCEEQTPLKPDPAIVKAMG-HIGFQ 309

  Fly   433 SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASST--------SASRMIYSSRN 489
            :.....||::..::...|.|.||:.::  .||......|..:..|.        :|:..:...|.
Mouse   310 AQDIEDSLRQRKFNQTMASYCLLKKQI--LKECDRPTRARPVNPSVTPFPSLVDTATTRLGLRRR 372

  Fly   490 DHQPT--------------QQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPT 540
            :::||              :..|:::.:.:|..|:|.:       .||....|........:.|.
Mouse   373 ENEPTCPWSSANRQVSVCGKSTSKKRDRRVSWPSVLGR-------PRHTAPTMDHTRTRTRSVPC 430

  Fly   541 V 541
            :
Mouse   431 I 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	102/251 (41%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	102/250 (41%)
Smok3a	NP_001119517.1	STKc_AMPK-like	27..275	CDD:270905	102/250 (41%)
		UBA_MARK_Par1	295..334	CDD:270522	10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..421		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810