DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik2 and Smok3a

DIOPT Version :10

Sequence 1:NP_569972.1 Gene:Sik2 / 31170 FlyBaseID:FBgn0025625 Length:1398 Species:Drosophila melanogaster
Sequence 2:NP_001119517.1 Gene:Smok3a / 545814 MGIID:3693943 Length:504 Species:Mus musculus


Alignment Length:456 Identity:138/456 - (30%)
Similarity:229/456 - (50%) Gaps:58/456 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 VGAGGISGKDLLKLKEPMR-----VGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLD 178
            :|.|.....:.|:.|.|:.     ...|.:..|||.|..|.||||:||:|...||:|.|.|.:. 
Mouse     1 MGPGSQQKSEKLRSKSPLADMDGLHAQYVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREY- 64

  Fly   179 QTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFK 243
              ...:|..|||::....||:||.|.||:|||..:|::.|......::.:|.|.|.:.|..||..
Mouse    65 --WCNRVISEVELLMMADHPNIISLLQVIETKKKVYLIMELCKGKSLYQHIRKAGYLQEHEARAL 127

  Fly   244 FWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEV 308
            |.|::||:.|||.:||||||||.:|::::.:..:||.|||.....|||:.|..:||:.|::||||
Mouse   128 FKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFCGTYPFSAPEV 192

  Fly   309 FEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRML 373
            .....|.||:||:|:||||||.:|.|.:|||..:::.|..|:|:|::.||..:|:|.:.|:..::
Mouse   193 LLSTPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIKKLVKRILAGKYSIPSRLSAELQDLLSLLM 257

  Fly   374 VLEPTRRYTIDQIKRHRWMC------PELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIG 432
            ...|..|.|:.::..|.|:.      |:            ..|.||.::|...|::.|. ::|..
Mouse   258 TANPKLRPTVAEVMVHPWVTEGSGVFPD------------PCEEQTPLKPDPAIVKAMG-HIGFQ 309

  Fly   433 SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASST--------SASRMIYSSRN 489
            :.....||::..::...|.|.||:.::  .||......|..:..|.        :|:..:...|.
Mouse   310 AQDIEDSLRQRKFNQTMASYCLLKKQI--LKECDRPTRARPVNPSVTPFPSLVDTATTRLGLRRR 372

  Fly   490 DHQPT--------------QQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPT 540
            :::||              :..|:::.:.:|..|:|.:       .||....|........:.|.
Mouse   373 ENEPTCPWSSANRQVSVCGKSTSKKRDRRVSWPSVLGR-------PRHTAPTMDHTRTRTRSVPC 430

  Fly   541 V 541
            :
Mouse   431 I 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik2NP_569972.1 STKc_SIK 140..392 CDD:270973 102/251 (41%)
UBA_SIK 418..458 CDD:270523 9/39 (23%)
Smok3aNP_001119517.1 STKc_AMPK-like 27..275 CDD:270905 102/250 (41%)
UBA_MARK_Par1 295..334 CDD:270522 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..421 7/38 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..468
Blue background indicates that the domain is not in the aligned region.

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