Protein Alignment Sik2 and Brsk1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001120809.1
• Gene: Brsk1 / 499073
• RGDID: 1563268
• Length: 778
• Species: Rattus norvegicus
• Alignment Length: 891
• Identity: 249/891 - (27%)
• Similarity: 367/891 - (41%)
• Gaps: 210/891 - (23%)

  Fly   105 GGGST------PGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRIT 163
            ||||.      |.|.|...|                 ..||.|.:|:|:|||...:|||..|.||
  Rat     9 GGGSPAYHLPHPHPHPPQHA-----------------QYVGPYRLEKTLGKGQTGLVKLGVHCIT 56

  Fly   164 KNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDY 228
            ..:||:||:::.:|.::.|.||.||:.|:|.::|||::||:.|.|.|..:|:|.|:.|.||:|||
  Rat    57 GQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDY 121

  Fly   229 IAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGEL 293
            :.|.||::...||..|.||:||:::||...|.|||||.||||||...||:|||||.::......|
  Rat   122 LVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSL 186

  Fly   294 LATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIP 358
            |.|.||||.||.|||.:|::|.|...|:||.||:|:.|:.||||||...|:.|.::|..|.|.:|
  Rat   187 LETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMP 251

  Fly   359 FFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM---------CPELLEHVLIAKYNLGAERQTS 414
            .|:..:|:.|:|.|:.:||.:|.:::||::|.|.         |.|......:|..:|.:..:
  Rat   252 HFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGE-- 314

  Fly   415 VEPSEDILRIMAEYVGIGSDKTR--ASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASS 477
            ::|  |:|..||. :|...|:.|  ..|:....:....||.||.||    ||:           .
  Rat   315 LDP--DVLESMAS-LGCFRDRERLHRELRSEEENQEKMIYYLLLDR----KER-----------Y 361

  Fly   478 TSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVP 542
            .|........|||..|.:::         ..|.:......:|..|....::|..:|.:|.:|.
  Rat   362 PSCEDQDLPPRNDVDPPRKR---------VDSPMLSRHGKRRPERKSMEVLSITDAGSGGSPV-- 415

  Fly   543 DPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLP----MRYTPLPTAASPAPSNC 603
                       |.:..|.:..||..:..::|....:.:|.:..|    ..::|.|.....|....
  Rat   416 -----------PTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGVGDEARGGG 469

  Fly   604 SSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGG------PVGAVGVPLA 662
            |.||.   ..:|.|..||                            |||      |..|...||.
  Rat   470 SPTSK---TQTLPSRGPR----------------------------GGGAGEQPPPPSARSTPLP 503

  Fly   663 SKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVP-------PPASTTPTSS 720
            .                                   ||.:..|.||.|       |.||.|.|..
  Rat   504 G-----------------------------------PPGSPRSSGGTPLHSPLHTPRASPTGTPG 533

  Fly   721 TAGPES-----GSAPCPGEING------------------KTIKTMSSSSSFDSKANLGQSF--R 760
            |..|.|     |.|.....:|.                  .|.:.|||.:...|.....:|:  .
  Rat   534 TTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGN 598

  Fly   761 YKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAK---SNGDSRSEKKVLA 822
            :....:..::|..|::.||...:.......:...:.|.....|.:..|:   |.|.|..:|.|..
  Rat   599 FISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRF 663

  Fly   823 QGSSSTDEGCETDQGNDPGSASQESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSG--QSHKM 885
            |...|:.||.|.....|         ||:|||..:......|..|....|:|.|..:.  .:|..
  Rat   664 QVDISSSEGPEPSPRRD---------GSSGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQ 719

  Fly   886 RS-YASSSSSSGVLAGSAGSYSKS-----------LSQNLSRGSSK 919
            .| .|.:...:|.....||:..:|           ||.:..||.||
  Rat   720 PSVQALADEKNGAQTRPAGTPPRSLQPPPGRPDPDLSSSPRRGPSK 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	117/251 (47%)
		UBA_SIK	418..458	CDD:270523	12/41 (29%)
Brsk1	NP_001120809.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		8/36 (22%)
		STKc_BRSK1_2	32..285	CDD:270983	118/252 (47%)
		UBA_BRSK	314..367	CDD:270525	18/72 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..548		51/273 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	719..778		12/47 (26%)