Protein Alignment Sik2 and AMPKalpha

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 196/652 - (30%)
• Similarity: 295/652 - (45%)
• Gaps: 158/652 - (24%)

  Fly   116 SSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQT 180
            :.||.||..:|:.|:|      :|.|.:..|:|.|.|..||:..|:||:.:||:||:::.::...
  Fly     9 AEAVAAGSANGQPLVK------IGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSL 67

  Fly   181 N-LQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKF 244
            : :.|:.||::.:|..:||||||||||:.|.:.|:::.||.|.||:||||.|:|::.|..||..|
  Fly    68 DVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFF 132

  Fly   245 WQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVF 309
            .||||.|:|||:..|||||||.||||||.||::||||||.||....||.|.|.||||.||||||.
  Fly   133 QQIISGVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVI 197

  Fly   310 EGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLV 374
            .||.|.|||:||||.||:||.|:||.||||...:.:|..::.||.|.||.:::.:..:|:.:||.
  Fly   198 SGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQ 262

  Fly   375 LEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRAS 439
            ::|.:|..|::||:|.|...:|..::    :....|:.::|..:..:..:..:: |:...:...|
  Fly   263 VDPLKRANIEEIKKHEWFQKDLPAYL----FPSSIEQDSNVIDTYAVAEVCTKF-GVKETEVHNS 322

  Fly   440 -LKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSK 503
             |..:.:|.:|..|.|:.|......:.:|                                 |..
  Fly   323 LLSGDPHDQLAIAYHLIIDNKRFADDAAN---------------------------------QIN 354

  Fly   504 TISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSH-- 566
            .|:...:                        ||:.|..|.|             |:|.:...|
  Fly   355 EINNFFV------------------------AGSPPPPPPP-------------PVPQSSMDHQA 382

  Fly   567 -LTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISL 630
             |.....|||... :||..     ||:|..|...||:.........|     .:|...|.:|:|:
  Fly   383 PLATVTVGGGTSA-SSGTA-----TPVPPVAGGTPSSTIPIRPHPER-----IAPMRDRQLAMSV 436

  Fly   631 SIDNNPSLANLRCREMMEAGGGPVGA----VGVPLASK--------------------------- 664
            ......:......|     ||.|:..    :|:...||
  Fly   437 QTSGGGAFPEKTAR-----GGTPIKRAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHV 496

  Fly   665 -----------------QLHQTISEFII---KQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGV 709
                             ||:|..::..:   |..|.|  .:.|....:.|....||   .||.||
  Fly   497 RVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTND--EVEQGDDVIMESLTPPP---LSVSGV 556

  Fly   710 PP 711
            .|
  Fly   557 MP 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	126/252 (50%)
		UBA_SIK	418..458	CDD:270523	7/40 (18%)
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	127/254 (50%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	12/96 (13%)
		AMPKA_C	457..580	CDD:213378	18/107 (17%)