Protein Alignment Sik2 and Gm14151

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001091446.1
• Gene: Gm14151 / 433486
• MGIID: 3651016
• Length: 640
• Species: Mus musculus
• Alignment Length: 698
• Identity: 188/698 - (26%)
• Similarity: 322/698 - (46%)
• Gaps: 129/698 - (18%)

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            |:|..|:|:|.|..||||.|.:|:.:|||||:.:::.:..    |..|:||||.|.|||||||..
Mouse    24 YEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNPL----VQPEIEIMKSLDHPHIIKLLH 84

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            :::|...|:||.|:|..||:.:.|.::|.::|......|.|::.|::|||:|||||||||.||:|
Mouse    85 IIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENIL 149

  Fly   271 LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGA 335
            ||...|:|:.|||.......|:.|.|:||:.||.|||:||.:.|.|...|:||||||||.:..|.
Mouse   150 LDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGC 214

  Fly   336 LPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHV 400
            |||:|.:.::::.::::|::...|.:|.|...:|.::|.:.|..|.|:..|.|.:|:.|:    .
Mouse   215 LPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKPD----N 275

  Fly   401 LIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQ 465
            ..:..:||...::..:||   :.::...:|....:.|.||::..:|.|.|.||:|       |:|
Mouse   276 EASPASLGENIESHPDPS---IMVLMGVMGYNPGEIRESLREKKFDQVMATYLML-------KQQ 330

  Fly   466 SNGLGASALASSTS-------ASRMIYSSRNDHQPT--QQQSQQQSKTISTSSILAKDQCHKRLS 521
                  ||..:.|:       ..||:.|:    :||  .|.:.:::.::.|.|..:.....:.|.
Mouse   331 ------SAWENKTTKKPDPRLCDRMLRST----EPTIKNQTAVRRASSVPTHSTFSLPNESESLE 385

  Fly   522 RHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLP-LTGHSHLTGYLNG-----GGVEVDA 580
            :.:...||.         ::|.....:..:..||....| |...:|....:.|     ...|..:
Mouse   386 KGKRTTMSH---------SMPPTRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSEESS 441

  Fly   581 SGIPL---PMRYTPLPTAASPAPSNCSSTSSRVGRHSLSS--SSPRSHRPVAISLSIDNNPSLAN 640
            :|..|   .::...|.|:...:.:..:.:.|:.....:||  :|....:....::|.:.||.|:.
Mouse   442 TGESLEHPSLKIHTLQTSMGVSKAGSTYSKSKGSSQCVSSHHTSVEEDQCEGTNISREINPPLSP 506

  Fly   641 LRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESS 705
            :..:|.:..               |||     .:....:.|.     .:|.|.    .||.:...
Mouse   507 VSPQENLMG---------------QLH-----IVTTAGSMDI-----MNTQVT----SPPFSRKE 542

  Fly   706 VGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEA--- 767
            ..| ..||.....|..:.|.:    ..|.::|                      |::.:.:|
Mouse   543 AKG-EGPAIQQRESRPSSPNT----LQGHLHG----------------------RHQTAPQAPFQ 580

  Fly   768 SKLFQTLQES----------PLPVEQR---TKRRVHVGSTNGSGGDSG 802
            .::::||:..          .||:|:|   |..|....|....||..|
Mouse   581 RRVWRTLRNGLIRGLRTLCCCLPIEKRVHPTNNRDLAVSQKSQGGSHG 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	106/250 (42%)
		UBA_SIK	418..458	CDD:270523	11/39 (28%)
Gm14151	NP_001091446.1	STKc_AMPK-like	23..270	CDD:270905	106/249 (43%)
		UBA_MARK_Par1	290..328	CDD:270522	12/47 (26%)