DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and MARK3

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001122390.2	Gene:	MARK3 / 4140	HGNCID:	6897	Length:	753	Species:	Homo sapiens

Alignment Length:	759	Identity:	268/759 - (35%)
Similarity:	382/759 - (50%)	Gaps:	175/759 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 EPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHP 198
            |...:|.|.:.:||||||||.||||||.:|..|||||||||:||:.|:|||::|||.|||.|.||
Human    49 EQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 113

  Fly   199 HIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRD 263
            :|:||::|:||:..:|::.||||.||:|||:..:|||.|..||.||.||:|||:|||:|.|||||
Human   114 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178

  Fly   264 LKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVL 328
            |||||||||.:||||||||||||.|..|..|.|:||||||||||:|:||:|.|||:|:|||||:|
Human   179 LKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 243

  Fly   329 YVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMC 393
            |.||.|:|||||..|:.||:|||.|::||||:||::||:|::|.|||.|.:|.|::||.:.||:
Human   244 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI- 307

  Fly   394 PELLEHVLIAKYNLGAER---QTSVEPSEDI-----LRIMAEYVGIG--SDKTRASLKKNTYDHV 448
                        |.|.|.   :..|||..||     :.||   ||:|  .::.:.||.|..||.:
Human   308 ------------NAGHEEDELKPFVEPELDISDQKRIDIM---VGMGYSQEEIQESLSKMKYDEI 357

  Fly   449 AAIYLLLQDRVSHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAK 513
            .|.|||| .|.|.:.:.|:    |:.:|:.|.:::..||..::...|....:..:::|:|
Human   358 TATYLLL-GRKSSELDASD----SSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSS----- 412

  Fly   514 DQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEV 578
             |..:|.|.|             |.|.:|
Human   413 -QKQRRYSDH-------------AGPAIP------------------------------------ 427

  Fly   579 DASGIPLPMRYTPLPTAASPAP----SNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLA 639
              |.:..|.| :...||.|...    |:..|:.|.||...::.:||        .|...:||:.|
Human   428 --SVVAYPKR-SQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASP--------MLGNASNPNKA 481

  Fly   640 NLRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDC--RALLQQSTAVAEGKDDPPKA 702
            ::..|:....         ||.::     |.|..:.:::|..|  |....:.:.:..||::....
Human   482 DIPERKKSST---------VPSSN-----TASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIP 532

  Fly   703 ESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRY------ 761
            :...    |.|||...||.|.|:....|          :..:|.|:|..:....::..|
Human   533 DQRT----PVASTHSISSAATPDRIRFP----------RGTASRSTFHGQPRERRTATYNGPPAS 583

  Fly   762 -KMSAEASKLFQTLQESP-----------------------LPVEQRTKRRVHVGSTNGSGGDSG 802
             .:|.||:.|.||.....                       ||.|.....| :.||:.....:..
Human   584 PSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGR-YEGSSRNVSAEQK 647

  Fly   803 QETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQGNDPGSASQE 846
            .|..:||    .||.:...:.         :|....|||...:|
Human   648 DENKEAK----PRSLRFTWSM---------KTTSSMDPGDMMRE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	162/251 (65%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	162/250 (65%)
MARK3	NP_001122390.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		STKc_MARK	55..307	CDD:270974	162/251 (65%)
		UBA_MARK3_4	325..367	CDD:270590	17/45 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..600		62/327 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..655		6/27 (22%)
		MARK1-3_C	654..751	CDD:213381	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810