DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and KP78b

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001163587.1	Gene:	KP78b / 41361	FlyBaseID:	FBgn0026063	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	755	Identity:	245/755 - (32%)
Similarity:	338/755 - (44%)	Gaps:	203/755 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 PGPS---------PTSSAVGAGGI----SGKDLLKLKEPMR---VGFYDIERTIGKGNFAVVKLA 158
            |||:         |:::|...||.    .|:...|.:..:.   .|.|.|.:|:||||||.||||
  Fly    16 PGPNTSISTTATPPSAAAQNVGGCFGSSGGRSSPKFQSYVNGNGYGVYKIIKTLGKGNFAKVKLA 80

  Fly   159 RHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQG 223
            .|..|..|||||:|||:.|:....||:||||.|||:|.||:|::|.||:|::..:|:|.||.|.|
  Fly    81 IHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGG 145

  Fly   224 EIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHF 288
            |:|:|:.|.|||.|..||..|.|::||:||||.|.||||||||||||||..|.:||||||||..|
  Fly   146 ELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTF 210

  Fly   289 KPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSG 353
            :|...|.|:||||||||||:|.||:|:|||:|.||||||||.||.|:|||||:.|:.||||||.|
  Fly   211 EPKAPLETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRG 275

  Fly   354 RFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLGAERQTSVEPS 418
            ::|:|:::|.|||.|||:.|||.||:|.::..:...||:             |:|.|:...:.|.
  Fly   276 KYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWI-------------NMGYEQGNGLRPF 327

  Fly   419 E-------DILRI-MAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALA 475
            :       |:.|: :...:|........|||...:|.:...|:||.               .|..
  Fly   328 QEKPMDLHDVNRLSLLSNMGHKPRDVEQSLKNQKFDDIYCTYMLLD---------------VAKP 377

  Fly   476 SSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPT 540
            .||:.|....||..:                                               |||
  Fly   378 RSTACSEKSGSSFRE-----------------------------------------------TPT 395

  Fly   541 VPDPGPGYYAKYGPLQLPLPLTGH----SHLTGYLNGGGVEVDASGIPLPM------RYTPLPTA 595
                     |..|..::|:|:...    |.:|..|:.......|:....||      ..||||..
  Fly   396 ---------AMPGSSRIPVPIAAPNVTISQVTFALDKSTPNRPAATSIRPMAPRLANALTPLPLT 451

  Fly   596 ASPAPSNCSSTSSRVG-RHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGV 659
            ..|....|.|.|.... |.|..||.|:|..|                     .:..|.||. |..
  Fly   452 PPPKKYICCSASKAANPRRSEPSSIPQSAMP---------------------KKGVGSPVD-VKT 494

  Fly   660 PLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGP 724
            .|.|.|....:::.:...| ...|:.:.||         |.:|..        .:.||.:.....
  Fly   495 TLLSAQRKLAVNQKLTSAS-HQIRSPITQS---------PSQASE--------CTRTPPTHFEML 541

  Fly   725 ESGSAPCPGEINGKTIKTMSSSSSF-DSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRR 788
            :|.|.|.      |.:|.::|:|.. .|..|..:..|....::.|..|             .:|.
  Fly   542 DSTSTPL------KVLKLVASNSQTPPSTENTNRPTRVGFFSKLSARF-------------VRRS 587

  Fly   789 VHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSST 828
            :|.|                        ||.:..||.:.|
  Fly   588 LHKG------------------------EKDISEQGRNLT 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	151/251 (60%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	151/250 (60%)
KP78b	NP_001163587.1	PKc_like	63..314	CDD:304357	151/250 (60%)
KP78b	NP_001163587.1	S_TKc	63..314	CDD:214567	151/250 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810