DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and Nuak1

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_001369005.1	Gene:	Nuak1 / 41256	FlyBaseID:	FBgn0262617	Length:	2803	Species:	Drosophila melanogaster

Alignment Length:	1475	Identity:	340/1475 - (23%)
Similarity:	537/1475 - (36%)	Gaps:	387/1475 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LDKPPENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGAASPSIDAIVACKDALLAQKLFASG 105
            :.||....| ||  .|.||| |.:...|||..:|:...:|.....||.|::
  Fly     3 ISKPDGTAP-NG--AAGGAE-AAAPTGLDATGNSLAHPSGIPQDQIDNIMS-------------- 49

  Fly   106 GGSTPGPSPTSSAVGAGGISGKDLLKL---KEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEV 167
                             ||:....:|:   ::.:|..| ||.:.:|:|.:..|:|..::.|..||
  Fly    50 -----------------GIANTGNVKMNNHRKKLRQRF-DIIKKLGQGTYGKVQLGINKETGQEV 96

  Fly   168 AIKIIDKSQLD-QTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAK 231
            |||.|.|.::: :.:|.::.|||:||..:.||:||.:|:|.|.:..:.:|.|:|:.||::||:::
  Fly    97 AIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSE 161

  Fly   232 YGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLAT 296
            ...::|..||..|.|:.:||.||||..|.|||||.||:|||...|.||||||.||.|....||.|
  Fly   162 RKVLTEEEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGT 226

  Fly   297 WCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFM 361
            :||||.||:||:.||..|.|||:|.|||||:||.||.|::|||||..:.|..::..|.:..| ..
  Fly   227 FCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEP-RK 290

  Fly   362 SSECEHLIRRMLVLEPTRRYTIDQIKRHRWM-------CPELLEHVLIAKYNLGAERQTSVEPSE 419
            .|....|||.||.:.|.:|.:|:||..|.|:       |.:|.|.:         ..||.|.  .
  Fly   291 PSRASTLIRDMLTVCPRKRASIEQICSHWWVNENDNVSCLDLAEDL---------ANQTPVR--L 344

  Fly   420 DIL------RIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASST 478
            |:|      .|.|:.:.:.|.:..|:.|....:.|..         ||.......:|    ..:|
  Fly   345 DVLLSLTPATITADQLVVPSAEGAAAAKAAANERVPR---------SHSVGSIRDMG----PPNT 396

  Fly   479 SASRMIY-------------SSRNDHQPTQQQSQQQSK---TISTSSILAKDQCHKRLSRHQTVL 527
            .|.|.|.             |......|.|...|.:.|   |:||.:........|....:.:.:
  Fly   397 EAERRILDMVAAGGEAALMPSPTRTITPAQSPVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFV 461

  Fly   528 MSERNAH-AGATPTVPDPGPGYYAKYGPLQLP--LPLTGHSHLTGYLNGGGVEVDASG--IPLPM 587
            :|:..|. ..|.||:.:|............:|  :|:..:|.         .::.|.|  ..|.|
  Fly   462 ISKDGAPLTEAPPTIIEPQATLMEAETIANIPEEVPVPSYSQ---------KDMQAVGDICDLLM 517

  Fly   588 RYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANL--RCREMMEAG 650
            .....|..|.|||:..:...:| |:......:|.......:.....|....|:|  ...|.....
  Fly   518 GTATTPAPAPPAPTPVARQPTR-GKLDAVVETPEEKDATKVIKKFVNKHKTADLVNAINESASKA 581

  Fly   651 GGPVGAVGVP----LASKQLHQTISEFII---KQSTEDCRALLQQSTAVAEGKDDPPKAES---- 704
            ..||.||..|    ..|.|...|:::|..   |....:.....|....||....:.||..|
  Fly   582 AAPVSAVAPPPFVRKCSLQDESTLNKFNAERRKSRILETAEKFQPPPPVAAAPPEKPKKLSIPGV 646

  Fly   705 SVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASK 769
            |||..........|:    |.:...|.|||:..:.                    :...:|.|::
  Fly   647 SVGSFKKEFEKKATN----PPAAEGPTPGELRAQE--------------------QVAAAAAAAQ 687

  Fly   770 LFQTLQ-ESPLPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLA-------QGSS 826
            ..:||. ..|.||..::.          .|.||.........:...||.:..:|       :.|.
  Fly   688 EAETLSTPPPSPVVAQSL----------EGSDSKNSVASISLDEARRSMENSIALLLQAQNESSK 742

  Fly   827 STDEGC---ETDQGNDPGSASQ-ESKGSN----------------------GGGSGNANGGPTSH 865
            ..|:.|   ||...::|.:..: |.|..|                      |.|.||..||....
  Fly   743 EVDQLCAQTETIGVSEPATQQERERKLKNARAIIGNAIQPVIRRPTPFYGIGNGFGNGMGGAVGA 807

  Fly   866 SSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDSLD 930
            |        |.|.:....:.:|.:|....||..:....:.|..:             |||
  Fly   808 S--------GATVNNAPKRAQSGSSFMGYSGATSPGTAATSPPI-------------SGP----- 846

  Fly   931 FALPSGKGSLPSCMGSSSMLATPTPASASPAGIS-SEHSSERSLYGSHNSCIHMPGALPLGLGLP 994
                                .|..|...||..:: ::.:.::.::|.               ||
  Fly   847 --------------------QTAPPVLISPNALAVAKQTIQQRIFGG---------------GL- 875

  Fly   995 QSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRASDGLVAQGLLSSGSLLGTSRVYGSYRYE 1059
                  |:||..|.          .|.|..::          .|...|:.|:         ::..
  Fly   876 ------PSPNNQPA----------NRRPATWQ----------PQASYSTASI---------FQPP 905

  Fly  1060 QAKRHGWLEIQQLQQLQQEAAVGHSHPHAHQHPHQHPHPHPQ-----AYGLE------------- 1106
            |::...:..:||..|.:.:.....|.|..       |.|.||     ||..:
  Fly   906 QSQSSPFKMLQQQYQQRCQEDQKQSCPFT-------PPPSPQNAASHAYAAQANSNNYGGNSNSG 963

  Fly  1107 --------ELCQFPN-GQFYALPGKHHPLLTLPHHHAHPAQHHHGHHSL---FHSGHQATPLL-- 1157
                    ..|...| |....:|..::.:    :....|..|:....:|   .::...||..|
  Fly   964 ASGGSSSNSRCNSSNIGNCNTMPYVNYNV----NSRTRPFNHNQAQDTLNTNANTSASATCALPV 1024

  Fly  1158 ---LEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQL---LQHRLLQQK 1216
               |:::.|.:        .||.|||........:.:.....|.:|...:.::   ::.|:.:|
  Fly  1025 AMWLKSSPGAE--------GPPTPPGAVKTSTASITLKSATLPRRKINAKAEVQLDIKPRIPEQ- 1080

  Fly  1217 RQLFQKQYALEAQLAGRHHHHQQHSHHHHHHFGHSLGPPPPPAPAPEHHLADELYELALLDRPRS 1281
                    ....|.|.|.....||.      .......||...|.|...:...|...|....|:
  Fly  1081 --------GAPPQPAMRFSTEMQHP------VADLRSAPPREGPIPYSPIKTTLQARATSLEPK- 1130

  Fly  1282 GTPRLQHSMTM---PGAHAFSQMNLKTSYISQSDQVPGAAPNGAGSGGSAAGVSCSAPPSTAPGT 1343
                 :|.:|:   |..||:.:.:..|:  ::|..:...:...:.|.|:....:.|....|:...
  Fly  1131 -----EHVITIQRPPTQHAYGRTSSNTT--TRSGSLSRQSTVESESEGTTTATNMSQATITSTSQ 1188

  Fly  1344 PTVKCKP--------------TTPHGHSLD-SDYHTSTPVLSLFT 1373
            | :|..|              .||...|:: |:...:|...|.||
  Fly  1189 P-IKKSPREFIIPIAVEGGGFITPRERSVEPSESSHTTSSRSTFT 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	115/252 (46%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	114/251 (45%)
Nuak1	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	115/254 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840