Protein Alignment Sik2 and sff

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_648814.3
• Gene: sff / 39732
• FlyBaseID: FBgn0036544
• Length: 861
• Species: Drosophila melanogaster
• Alignment Length: 981
• Identity: 270/981 - (27%)
• Similarity: 398/981 - (40%)
• Gaps: 269/981 - (27%)

  Fly   138 VGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIK 202
            ||.|.:|:|:|||...:|||..|.:...:||||||::.:|.::.|.||.||:.|||.:.|||::.
  Fly    15 VGPYRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLG 79

  Fly   203 LYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAE 267
            |..|.|.|..:|::.|:.|.||:|||:.|.||::...||..|.|||||:::||...|.|||||.|
  Fly    80 LSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPE 144

  Fly   268 NLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLV 332
            |||||...||||||||.::....|.:|.|.||||.||.|||..|::|.|.:.|:||.||:||.|:
  Fly   145 NLLLDEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALL 209

  Fly   333 CGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRW------ 391
            .||||||...|:.|.::|..|.|.||.|:..:|:.|:|.|:.:.|.||.|:.:|.||.|
  Fly   210 VGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPWVTAGGK 274

  Fly   392 --------MCPELLEHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTR--ASLKKNTYD 446
                    |...:..||:        ...|:|:|  |:|..:.. :|...:|.:  ..|..::::
  Fly   275 GELELELPMMEVVQTHVI--------PTATAVDP--DVLNAICS-LGCFKEKEKLIQELLSSSHN 328

  Fly   447 HVAAIYLLL------------QDRVSHKKEQS----------------NGLGASALASSTSASRM 483
            ....||.||            .|.::.|....                ||..|.:....:..|.:
  Fly   329 TEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYGQISEGSPL 393

  Fly   484 I----------YSSRNDHQPTQQQSQQQSKTISTSSILAKD-----QCHKRLSRHQTVLMSERNA 533
            .          |||..:|       |::|.|..|||:.:..     :|:..:|      .:::.|
  Fly   394 TPRRQAFNFRSYSSTRNH-------QRRSPTTVTSSVRSSSYHSPTRCNSPMS------SAQQQA 445

  Fly   534 HAGATPTVPDPGPGYYAKYGPLQLPLPLTGH--------SH-----LTGYL-------------- 571
            :|.:.|:.|..|. .::.||...    .:||        ||     :.|.:
  Fly   446 NAISRPSSPAAGT-RHSTYGDRD----RSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDSL 505

  Fly   572 ---NGGGVEVDAS--GIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLS 631
               .|||...|..  |||          ..||..::..|||:....|..::|.|    .:|||:.
  Fly   506 RQERGGGSPRDRGDCGIP----------PGSPGGNSSGSTSASPSVHHRANSGP----TIAISMF 556

  Fly   632 ID-NNPSLANLRCREMMEAG-----GGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQST 690
            .| ::.|:.|.....||...     |.|....|..|...:|....:.|:  .|....|..:|.|.
  Fly   557 HDPDSNSVVNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFL--GSPRFHRRKMQVSA 619

  Fly   691 AVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGE-------------INGKTIKT 742
                  |:              ...||.||   ||.......|.             :.||.|.|
  Fly   620 ------DE--------------VHLTPESS---PELTKRSWFGNLITTEKDETFTILVKGKPIAT 661

  Fly   743 MSSS--SSFDSKANLGQ------SFR--YKMSAEASKLFQTLQESPLPVEQRTKRRVHVGS--TN 795
            :.:.  .:|.|.|.|..      |||  ||.:.....:||          :..|.:|.:.:  ..
  Fly   662 VKAHLIHAFLSMAELSHSVVSPTSFRVEYKRNGNGPVMFQ----------RHVKFQVDISAICKQ 716

  Fly   796 GSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCETDQG-----NDPGSASQESKGSNGGGS 855
            |...|..........:|:.|..:::           ||..|.     ..||.:|.
  Fly   717 GDIADMLFALTFTLLSGNIRRFRRI-----------CEHIQSQVCSKRFPGPSSP---------- 760

  Fly   856 GNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSYSKSLSQNLSRGSSKS 920
                  ||..|   :|:.|               |.|||.|.::....||.:.:.:|     ...
  Fly   761 ------PTVTS---VTQAV---------------SESSSCGSVSSERLSYKRQVIEN-----DME 796

  Fly   921 NCSGPYDSLDFALPSGKGSLPSCMGSSSMLATPTPASASPAGISS-----EHSSERSLYGSHNSC 980
            |     ||: |:..||.|...|...:::  |.|.....||..:.|     ||...|.|. |....
  Fly   797 N-----DSI-FSYKSGNGRRASTTNNNN--ANPVDIPGSPIAVRSNSETAEHERNRELQ-SERQA 852

  Fly   981 IHMPGA 986
            ..|.|:
  Fly   853 TTMSGS 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	122/265 (46%)
		UBA_SIK	418..458	CDD:270523	9/53 (17%)
sff	NP_648814.3	STKc_BRSK1_2	16..269	CDD:270983	122/252 (48%)
		UBA_BRSK	298..350	CDD:270525	11/54 (20%)