DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik2 and 4921509C19Rik

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	NP_941057.1	Gene:	4921509C19Rik / 381393	MGIID:	2685851	Length:	640	Species:	Mus musculus

Alignment Length:	708	Identity:	190/708 - (26%)
Similarity:	315/708 - (44%)	Gaps:	149/708 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            |:|..|:|:|.|..||||.|.:|:.:|||||:.||:.:..    |..|:||||.|.|||||||..
Mouse    24 YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSL----VQPEIEIMKSLDHPHIIKLLH 84

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            :::|...|:||.|:|..||:...|.::|.::|......|.|::.|::|||:|||||||||.||:|
Mouse    85 IIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENIL 149

  Fly   271 LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGA 335
            ||...|:|:.|||.......|:.|.|:||:.||.|||:||.:.|.|...|:||||||||.:..|.
Mouse   150 LDHRGNVKLTDFGLGTKIIMGQKLVTFCGTLPYCAPELFEDRGYDGRATDVWSLGVVLYFMATGC 214

  Fly   336 LPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHV 400
            |||:|.:.::::.::::|::...|.:|.|...:|.::|.:.|..|.|:..|.|.:|:.|:    .
Mouse   215 LPFNGYSYEAIKQKIIAGKYPRSFSLSPELWEVIAKLLTVNPGERPTVHDIARFKWLKPD----N 275

  Fly   401 LIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQ 465
            ..:..:||...::..:||   :.::...:|....:.|.||::..:|.|.|.||:|       |:|
Mouse   276 EASPASLGENIESHPDPS---IMVLMGVMGYNPGEIRESLREKKFDQVMATYLML-------KQQ 330

  Fly   466 SNGLGASALASSTS-------ASRMIYSSRNDHQPT--QQQSQQQSKTISTSSILAKDQCHKRLS 521
                  ||..:.|:       ..||:.|:    :||  .|.|.:::.::.|.|..:.....:.|.
Mouse   331 ------SAWENKTTKKPDPRLCDRMLRST----EPTIKNQTSVRRASSVPTHSTFSLPNESESLE 385

  Fly   522 RHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLP-LTGHSHLTGYLNG-----GGVEVDA 580
            :.:...||.         ::|.....:..:..||....| |...:|....:.|     ...|..:
Mouse   386 KGKRTTMSH---------SMPPTRNCFNEETTPLHSICPQLVQKAHYRRSIWGETEISDTSEESS 441

  Fly   581 SGIPL---PMRYTPLPTAASPAPSNCSSTSSRVGRHSLSS--SSPRSHRPVAISLSIDNNPSLAN 640
            :|..|   .::...|.|:...:.:..:.:.|:.....:||  :|....:....::|.:.||.|:.
Mouse   442 TGESLEHPSLKIHTLQTSMGVSKAGSTYSKSKGSSQCVSSHHTSVEEDQCEGTNISREINPPLSP 506

  Fly   641 LRCREMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESS 705
            :..:|.:..               |||     .:....:.|.     .:|.|.    .||.:...
Mouse   507 VSPQENLMG---------------QLH-----IVTTAGSMDI-----MNTQVT----SPPFSRKE 542

  Fly   706 VGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKL 770
            ..| ..||.....|..:.|.:    ..|.::|:.
Mouse   543 AKG-EGPALQQRESRPSSPNT----LQGHLHGRR------------------------------- 571

  Fly   771 FQTLQESP-----------------------LPVEQR---TKRRVHVGSTNGSGGDSG 802
             ||:.::|                       ||:|:|   |..|....|....||..|
Mouse   572 -QTVPQAPFQRRVWRTLRNGLIRGLRTLCCCLPIERRVHPTNNRDLAVSQKSHGGSHG 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	108/250 (43%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	108/250 (43%)
4921509C19Rik	NP_941057.1	STKc_AMPK-like	23..270	CDD:270905	108/249 (43%)
		UBA_MARK_Par1	290..328	CDD:270522	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..399		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..509		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..576		13/85 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..640		4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810