Protein Alignment Sik2 and Sik3

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Alignment Length: 1563
• Identity: 403/1563 - (25%)
• Similarity: 594/1563 - (38%)
• Gaps: 556/1563 - (35%)

  Fly   109 TPGPS---PTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIK 170
            |.||:   ||||......:.....:.:.:.:|||:|::|:|||||||||||||.:.:||.:||||
  Fly     6 TAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIK 70

  Fly   171 IIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRM 235
            ||||:.|::..|.|.:||:.|:|.|:||||.:||:|||:::|||:|:|||..|||||::...|||
  Fly    71 IIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRM 135

  Fly   236 SESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGS 300
            .|..|...|.|::|||.|||::|:|||||||||:|||.:||||:||||||||::.|..|.|||||
  Fly   136 KEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGS 200

  Fly   301 PPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSEC 365
            |||||||||:|.:|.||:.||||||||||.||||||||||.|:..|:.||:.|:||||||||.||
  Fly   201 PPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQEC 265

  Fly   366 EHLIRRMLVLEPTRRYTIDQIKRHRWMC---PELLEHV----------LIAK----YNLGAERQT 413
            |.|||.|||:||.|||||.||.:|||:.   .|:.|..          .::|    .:||:...:
  Fly   266 EQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDS 330

  Fly   414 SVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASA-LASS 477
            ..:....::..|.:..|:.:|....|:.:..:|::.|||.||.|::..::.::..|...| ||.|
  Fly   331 PPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYS 395

  Fly   478 TSASRMIYSSRNDH-QPTQQQSQQQSKTISTS-----------SILAKD---------QCHKRLS 521
            .|....|.:...|. :|.:|:|..:...:|.:           |.:|.|         :|..| |
  Fly   396 RSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLAR-S 459

  Fly   522 RHQTVLMSERNAHAG------------------------ATPTVPD---------PGPGYYAKYG 553
            ....|.....:||||                        |.|.||.         ..|.....|.
  Fly   460 NDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYY 524

  Fly   554 PLQLPL----PLTGHS------HL-----------------------------TGYLNG--GGVE 577
            |:.||:    ||  |:      ||                             ||.:.|  .|.:
  Fly   525 PVNLPMLQNQPL--HNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQ 587

  Fly   578 VDASGI---------PLPMR-YTPL---------------------------------------- 592
            :|.:|.         ||.:: .:||
  Fly   588 MDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGC 652

  Fly   593 ------------------PTAAS----------------PA--PSNCSSTSSRVGR-------HS 614
                              ||.:|                |.  |.......||:.|       .|
  Fly   653 TEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKS 717

  Fly   615 LSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLA---SKQLHQTISEFI-- 674
            ||.|.|....||..:|.:..:..|:......::.|.||     .|||.   ::::|:.:...:
  Fly   718 LSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGG-----SVPLVAPNNRRIHRVVHSKLPT 777

  Fly   675 ------------IKQSTE-----------DCRAL----LQQSTAVAEGKDDPPKAESSVG--GVP 710
                        :::::|           :|::|    .|::..||   ..||..|:|:.  |.|
  Fly   778 VQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQKGIAQRNFLVA---PSPPLLENSISLPGSP 839

  Fly   711 ---PPASTTPTSSTAG------PESGSAPCPG------------EINGKTIKT------------ 742
               .|......:...|      ||:.....|.            ||..|.|.|
  Fly   840 IHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHVVPMDLAPLLG 904

  Fly   743 ---MSSSSSFDSKANLGQS-FRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQ 803
               .:||::..|..:|.|| |.:....:..:...:...|||.:.|              ||....
  Fly   905 LAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQ--------------GGAVNA 955

  Fly   804 ETNDAKSN------GDSRSEKKVLA-------------------QGSSSTDEGCETDQGND---- 839
            ....||..      |.::.:...||                   ..:|::..||::...:.
  Fly   956 SLTSAKQMFGQPICGYTQYQPMTLALQPQHQQQLVGQFSSINLGASNSNSSSGCQSPVFSTSFSG 1020

  Fly   840 --------PGSAS------QESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYAS 890
                    ||:|.      |.:||.:|..:|.|.|        .:||  ||
  Fly  1021 SCSPNPYLPGAAGGSSPLHQITKGISGLSTGCAGG--------SITR--GT-------------- 1061

  Fly   891 SSSSSGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDS--LDFA--------------------- 932
            |::|.|..|.:|.:....||.::        |.|..|.  .|:|
  Fly  1062 SAASEGAAAAAAANQPLDLSMDV--------CGGVMDQQPTDYAATNWFMPTASYYDMKPLNLSP 1118

  Fly   933 ------LPSGKGSLPSCM-----GSSSM---LATPTPASASPAGI-------------------S 964
                  :|:...|...|:     |:..|   ::|.||.:....||                   |
  Fly  1119 AQPVRVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGGITPQICLTDVQGSEITLVALS 1183

  Fly   965 SEHS--SERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFRE 1027
            |::|  ||.||..      |.|.....||.:.:.|:..|:..       .|:
  Fly  1184 SDNSRDSEDSLEQ------HTPVMSLQGLIITEPSSDMPSIT-------RGI------------- 1222

  Fly  1028 GRRAS----DGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEI-----------QQLQQLQQ 1077
            ||:||    .|..:...::|||.........:....|.:|.....:           ..|...|:
  Fly  1223 GRKASLDCDSGAGSHCPVASGSSHANQSQTQAQTEAQCRRGSDKSLGFSDDSLSNDSNNLSPCQE 1287

  Fly  1078 EAAVGHSHPHAHQHPHQHP---HPHPQAY-----GLEELCQFPNGQFYALPGKHHPLLTLPH--- 1131
            .:|.......:|.....|.   |..|.:.     ..:|:|       |.:|        |||
  Fly  1288 PSASSGFKSDSHSEMGDHTECGHLTPDSMCDSRRMSDEMC-------YEVP--------LPHECS 1337

  Fly  1132 --------------------------HHAHPAQHHHG---HHSLFHSGHQATPLLLEAAAGGDMY 1167
                                      |....:....|   .||...:...:.||..|||:  .:.
  Fly  1338 NLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGAESRHSSASNASTSNPLACEAAS--LLA 1400

  Fly  1168 GHGCYAPPPPPPGL-YT----------------HHQLGVGM---AVPMSPMQKPPLQQQLLQHRL 1212
            .|..|..|.....| |:                ||..|.|:   .:.....:...:.|||:....
  Fly  1401 SHSGYGEPTTNLSLEYSGGLQIELQVCEGRSRDHHGAGKGIKLRRISGDQFEYGKICQQLISTIT 1465

  Fly  1213 LQQ 1215
            :||
  Fly  1466 MQQ 1468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	165/251 (66%)
		UBA_SIK	418..458	CDD:270523	10/39 (26%)
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	165/251 (66%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)