Protein Alignment Sik2 and Snrk

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Alignment Length: 1014
• Identity: 237/1014 - (23%)
• Similarity: 394/1014 - (38%)
• Gaps: 333/1014 - (32%)

  Fly   122 GGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVY 186
            ||:|...:        .|.||:|.|:|.|:|||||||||..|..:||:|::||::||..:...::
  Fly     9 GGVSDGKI--------AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLF 65

  Fly   187 REVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKY-GRMSESAARFKFWQIISA 250
            :||..||.::||::::||:|::|:..:|:|.|....|:::|||.|: ..:||..||..|.||:.|
  Fly    66 QEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRA 130

  Fly   251 VEYCHKKGIVHRDLKAENLLLDLNMN-IKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQY 314
            :.|||:..:||||||.||::....:. :|:.||||||.|.||:.|.|:|||..|:|||:..|..|
  Fly   131 ITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSY 195

  Fly   315 TGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTR 379
            ..|.:|||||||:||:||||..||:.:........::..::.:|..:|::|..||..|||.:|.:
  Fly   196 DAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKK 260

  Fly   380 RYTIDQIKRHRWMCP--------ELLEHV--LIAKYNLGAERQT---------SVEPSEDILRIM 425
            |.|:::|....|:.|        ...||.  |:::..||.|...         ::...|:||:
  Fly   261 RATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQ-- 323

  Fly   426 AEYVGIGSDKTRASLKKNTYDHVAAIYLLLQD-RVSHKKEQSNGLGASALASSTSASRMIYSSRN 489
                         :|.||.|:|:.|.|.||.: |:..::|:        ||
  Fly   324 -------------ALDKNKYNHITATYFLLAELRLRRRREE--------LA-------------- 353

  Fly   490 DHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGP 554
                      |:.:.::.:|:...|...|                  ..|..|.|
  Fly   354 ----------QKQRLLNDASMKVGDASRK------------------LVPEKPSP---------- 380

  Fly   555 LQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSS 619
                                 .|....|:|:.:..||....|:..
  Fly   381 ---------------------TEAQKGGVPISINVTPAAQFANDG-------------------- 404

  Fly   620 PRSHRPVAISLSIDNNPSLANLRC---REMMEAGGGPVGAVGVPLASKQLHQTISEFIIKQSTED 681
                          ..|...:.:|   ||..|                           ::|..:
  Fly   405 --------------GKPDKRSRKCSIVREEDE---------------------------EESATE 428

  Fly   682 CRA----LLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSAPCPGEINGKTI-- 740
            |.|    |...|::..|...|.|.:.|    :...:|:.|.:.|.|.:..::..|.....|.:
  Fly   429 CTAVGNELKVTSSSRREAFSDSPFSRS----IHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVS 489

  Fly   741 ---------KTMSSSSSFDSKANLGQSFRYKMSAEASKL--FQTLQESPLPVEQRTK-RRVHVGS 793
                     |.|..|:..|.....|..     ..|..||  ..:..::|:...:||| .::...|
  Fly   490 VDATLAHKLKQMEKSAKIDEDTLSGLK-----ELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPS 549

  Fly   794 TNGS--GGDSGQETNDAKSN---GDS----RSEKKVLAQGSSSTDE------GCETDQGN----- 838
            .:.|  ..|..:..|..|.|   ||:    |..::.....||.:.:      |..::.||
  Fly   550 CSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFISKS 614

  Fly   839 --------------DPGSASQESKGSNG----------------------GGSGNANGGPTSH-- 865
                          :|.:.|.|::.|:.                      ..|..|..|.:::
  Fly   615 GSVSGKKEGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAERQLADSSTATTGNSTNRR 679

  Fly   866 ----SSSDLTRLVGTTTSGQSHKMR------SYASSSSSS---------GVLAGSAGSYSKSLSQ 911
                .|..|.|:    |..|.::||      |.|:|||||         .:|:.:..::  |:::
  Fly   680 RRIRESQSLDRI----TEAQEYEMRHRCYAESEAASSSSSSTQHIDQRYSLLSLNTSTF--SVAE 738

  Fly   912 NLSRGSSKSNCSGPYDSLDFALPSGKGSL---------------------PSCMGSSSMLATPTP 955
            .......:::.:...|.:...|.:.|.:|                     .|.:..||..|....
  Fly   739 TKEEYDEEADATNATDQIMNTLNAAKATLQQEQYFNNNTNLSRNFNHNHNQSIIHISSQKANGKK 803

  Fly   956 ASASPAGI----SSEH----SSERSLYGSHNSCIHMPGA 986
            ::.:|..|    |.||    ..::||    ...||:.|:
  Fly   804 SNETPKDIYNLNSIEHIDLILEDKSL----TKAIHVTGS 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	109/253 (43%)
		UBA_SIK	418..458	CDD:270523	12/40 (30%)
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	110/264 (42%)
		UBA_SNRK	296..338	CDD:270524	12/56 (21%)