Protein Alignment Sik2 and mark3a

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_021336197.1
• Gene: mark3a / 334300
• ZFINID: ZDB-GENE-030131-6232
• Length: 746
• Species: Danio rerio
• Alignment Length: 757
• Identity: 272/757 - (35%)
• Similarity: 390/757 - (51%)
• Gaps: 132/757 - (17%)

  Fly    98 AQKLFASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRI 162
            |:....:|.|.:...|.:..:.|....||..|..: .|: :|.|.:.:||||||||.||||||.:
Zfish    16 AENHTTNGHGRSEVTSRSVRSSGRNRNSGSGLDDV-HPV-IGNYRLLKTIGKGNFAKVKLARHIL 78

  Fly   163 TKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFD 227
            |.:|||||:|||:||:.|:|||:.|||.|||.|.||:|:||::|:||:..:::|.||||.||:||
Zfish    79 TGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFD 143

  Fly   228 YIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGE 292
            |:..:|||.|..||.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|.
Zfish   144 YLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGS 208

  Fly   293 LLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRI 357
            .|.|:||||||||||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||
Zfish   209 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 273

  Fly   358 PFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLG---AERQTSVEPSE 419
            ||:||::||:|::|.|||.|.:|.|::||.:.||:             |.|   .|.:...||..
Zfish   274 PFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWI-------------NSGFEDDELKPFTEPDA 325

  Fly   420 DI--LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSA 480
            ||  .:.:...||:|  .:|...||.|..||.|.|||||| .|.:|::...:...::...:.|..
Zfish   326 DISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLLL-GRKTHEEVSDSSSNSNLSVAKTRP 389

  Fly   481 SRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRH-QTVLMSERNAHAGATPTVPDP 544
            |    |..|...|:..:.|   ::||:|.       .::..|| :.|.:...||.:.:...|
Zfish   390 S----SEMNSQSPSHLKVQ---RSISSSE-------SRKSRRHSEQVGVVANNALSNSKRVV--- 437

  Fly   545 GPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAP-----SNCS 604
                           |:|..|.:.   ..|||..           ..||..:.|:|     :|.:
Zfish   438 ---------------PVTADSEVK---QEGGVIA-----------RKLPNHSPPSPLLGNANNPN 473

  Fly   605 ST-------SSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLA 662
            .|       .:.:..:::|.|...|.|...:....:|...|:.:        ..|...:|.:..:
Zfish   474 KTEIPDRKKGNSITSNNISGSGSMSRRNTYVCTERNNTDRLSVI--------PNGKENSVSLSPS 530

  Fly   663 SK----QLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAG 723
            |:    ..| :||..:....|...|....:||...:.:|   :..::..|  ||||.....|.|
Zfish   531 SRDPGASTH-SISTSVTPDKTRFPRGSASRSTFHGQVRD---RRTATYNG--PPASPAQPRSRA- 588

  Fly   724 PESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRR 788
                        |...:.|..:|..  ::.|:  |||:      ||...|        |.....|
Zfish   589 ------------NANNLLTKLTSKL--TRRNM--SFRF------SKRVST--------EFERSGR 623

  Fly   789 VHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDE 830
            ....|.:.||.....|..|.| :|..||.:...:..::||.|
Zfish   624 FEGSSRHVSGDQQKDEGKDGK-DGKPRSLRFTWSMNTTSTME 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	161/251 (64%)
		UBA_SIK	418..458	CDD:270523	18/43 (42%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	161/251 (64%)
		UBA_like_SF	326..368	CDD:473871	18/42 (43%)
		MARK1-3_C	647..744	CDD:213381	5/18 (28%)