DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik2 and mark3a

DIOPT Version :9

Sequence 1:	NP_569972.1	Gene:	Sik2 / 31170	FlyBaseID:	FBgn0025625	Length:	1398	Species:	Drosophila melanogaster
Sequence 2:	XP_021336197.1	Gene:	mark3a / 334300	ZFINID:	ZDB-GENE-030131-6232	Length:	746	Species:	Danio rerio

Alignment Length:	757	Identity:	272/757 - (35%)
Similarity:	390/757 - (51%)	Gaps:	132/757 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 AQKLFASGGGSTPGPSPTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRI 162
            |:....:|.|.:...|.:..:.|....||..|..: .|: :|.|.:.:||||||||.||||||.:
Zfish    16 AENHTTNGHGRSEVTSRSVRSSGRNRNSGSGLDDV-HPV-IGNYRLLKTIGKGNFAKVKLARHIL 78

  Fly   163 TKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFD 227
            |.:|||||:|||:||:.|:|||:.|||.|||.|.||:|:||::|:||:..:::|.||||.||:||
Zfish    79 TGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVKLFEVIETEKTLFLVMEYASGGEVFD 143

  Fly   228 YIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGE 292
            |:..:|||.|..||.||.||:|||:|||:|.||||||||||||||.:||||||||||||.|..|.
Zfish   144 YLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDGDMNIKIADFGFSNEFMVGS 208

  Fly   293 LLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRI 357
            .|.|:||||||||||:|:||:|.|||:|:|||||:||.||.|:|||||..|:.||:|||.|::||
Zfish   209 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 273

  Fly   358 PFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHVLIAKYNLG---AERQTSVEPSE 419
            ||:||::||:|::|.|||.|.:|.|::||.:.||:             |.|   .|.:...||..
Zfish   274 PFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWI-------------NSGFEDDELKPFTEPDA 325

  Fly   420 DI--LRIMAEYVGIG--SDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASALASSTSA 480
            ||  .:.:...||:|  .:|...||.|..||.|.|||||| .|.:|::...:...::...:.|..
Zfish   326 DISDQKRIDVIVGMGFSKEKIHESLFKMNYDEVTAIYLLL-GRKTHEEVSDSSSNSNLSVAKTRP 389

  Fly   481 SRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRH-QTVLMSERNAHAGATPTVPDP 544
            |    |..|...|:..:.|   ::||:|.       .::..|| :.|.:...||.:.:...|
Zfish   390 S----SEMNSQSPSHLKVQ---RSISSSE-------SRKSRRHSEQVGVVANNALSNSKRVV--- 437

  Fly   545 GPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPLPMRYTPLPTAASPAP-----SNCS 604
                           |:|..|.:.   ..|||..           ..||..:.|:|     :|.:
Zfish   438 ---------------PVTADSEVK---QEGGVIA-----------RKLPNHSPPSPLLGNANNPN 473

  Fly   605 ST-------SSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLA 662
            .|       .:.:..:::|.|...|.|...:....:|...|:.:        ..|...:|.:..:
Zfish   474 KTEIPDRKKGNSITSNNISGSGSMSRRNTYVCTERNNTDRLSVI--------PNGKENSVSLSPS 530

  Fly   663 SK----QLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAG 723
            |:    ..| :||..:....|...|....:||...:.:|   :..::..|  ||||.....|.|
Zfish   531 SRDPGASTH-SISTSVTPDKTRFPRGSASRSTFHGQVRD---RRTATYNG--PPASPAQPRSRA- 588

  Fly   724 PESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRR 788
                        |...:.|..:|..  ::.|:  |||:      ||...|        |.....|
Zfish   589 ------------NANNLLTKLTSKL--TRRNM--SFRF------SKRVST--------EFERSGR 623

  Fly   789 VHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDE 830
            ....|.:.||.....|..|.| :|..||.:...:..::||.|
Zfish   624 FEGSSRHVSGDQQKDEGKDGK-DGKPRSLRFTWSMNTTSTME 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	161/251 (64%)
Sik2	NP_569972.1	S_TKc	141..392	CDD:214567	161/250 (64%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	161/251 (64%)
		UBA_like_SF	326..368	CDD:328731	18/42 (43%)
		MARK1-3_C	647..744	CDD:213381	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810