Protein Alignment Sik2 and Sik2

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001414257.1
• Gene: Sik2 / 315649
• RGDID: 1559698
• Length: 932
• Species: Rattus norvegicus
• Alignment Length: 1321
• Identity: 403/1321 - (30%)
• Similarity: 536/1321 - (40%)
• Gaps: 484/1321 - (36%)

  Fly   135 PMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPH 199
            |:||||||||.|:||||||||||.||||||.|||||||||||||..||:|:||||:|||.|.|||
  Rat    14 PVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPH 78

  Fly   200 IIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDL 264
            |||||||||||:|:|:|:|||..||||||:|.:||::||.||.|||||:|||:|||.:.:|||||
  Rat    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHSRKVVHRDL 143

  Fly   265 KAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLY 329
            ||||||||.:||||||||||.|.||.|||||||||||||||||||||:||.||::||||:|||||
  Rat   144 KAENLLLDNSMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLY 208

  Fly   330 VLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCP 394
            |||||||||||.||..||.|||.||||||:|||.:|||||||||||:|::|.:|.|||.|:||..
  Rat   209 VLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLI 273

  Fly   395 EL-LEHVLIAKYNLGAERQTSV-EPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQD 457
            |: ::..::  |....|.:.|: |.:|.:||:| ..:||...||..||:..:|:|.||||.||.:
  Rat   274 EVPVQRPIL--YPQEQENEPSIGEFNEQVLRLM-HSLGIDQQKTIESLQNKSYNHFAAIYFLLVE 335

  Fly   458 RV-SHKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQ---SQQQSKTISTSSILAKDQCHK 518
            |: ||:..                           .|.:|:   .|::..||:..::
  Rat   336 RLKSHRSS---------------------------FPVEQRLDGRQRRPSTIAEQTV-------- 365

  Fly   519 RLSRHQTVLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGI 583
              ::.|||                                                       |:
  Rat   366 --AKAQTV-------------------------------------------------------GL 373

  Fly   584 PLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCREMME 648
            |:.:                                   |.|              |||
  Rat   374 PVTL-----------------------------------HPP--------------NLR------ 383

  Fly   649 AGGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPA 713
                                                 |.:||.:       |:| |:|.....||
  Rat   384 -------------------------------------LMRSTLL-------PQA-SNVEAFSFPA 403

  Fly   714 STTPTSSTAGPESGSAPCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESP 778
            |:               ||.|                      .:|..:...:..|:...|.:..
  Rat   404 SS---------------CPAE----------------------AAFMEEECVDTPKVNGCLLDPV 431

  Fly   779 LPVEQRTKRRVHVGSTNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTDEGCET--DQGNDPG 841
            .||..|                     ...:|...|..|        :|.|||.||  :...||.
  Rat   432 PPVLVR---------------------KGCQSLPSSMME--------TSIDEGLETEGEAEEDPS 467

  Fly   842 SASQESKGSNGGGSGNANGGPTSHSSSDLT-RLVGTTTSGQSHKMRSYASSSSSSGVLAGSAGSY 905
            .|.:..:.:        ..|...|:.|::| :||....:|   |:.|.:.|.|..
  Rat   468 QAFEAFQAT--------RSGQRRHTLSEVTNQLVVLPRAG---KVFSMSDSPSLD---------- 511

  Fly   906 SKSLSQNLSRGSSKSNCSGPYDSLDFALPSGKGSLPSCMGSSSMLATP----TPASASPAGISSE 966
              |:......||::.:.:.|.||     ||.|..:.:...|..|  ||    .||:.:...:||:
  Rat   512 --SVDSEYDMGSAQRDLNFPEDS-----PSLKDIMLANQPSPRM--TPFISLRPANPAMQALSSQ 567

  Fly   967 HSSERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFREGRRA 1031
            ...      :||                                         |||:.|||||||
  Rat   568 RRE------AHN-----------------------------------------RSPVSFREGRRA 585

  Fly  1032 SDGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEIQQLQ----QLQQEA--AVGHSHPHAHQ 1090
            ||..:.||:::          :..:....|:..|.||:.::|    |::.:|  .:..:.|....
  Rat   586 SDTSLTQGIVA----------FRQHLQNLARTKGILELNKVQLLYEQIRSDADPTLTSTAPQLQD 640

  Fly  1091 HPHQHPHPHPQAYGLEELCQFPNGQFYALPGKHHPLLTLPHHHAHP-AQHHHGHHSLFHSGHQAT 1154
            .....|.        ||:.| ......||....||.|:.......| .||.....||......|.
  Rat   641 LSSSCPQ--------EEISQ-RQESVSALSASMHPQLSPQRSLETPYLQHRLQKPSLLPKAQNAC 696

  Fly  1155 PLLLEAAAGGDMYGHGCYAPPPPPPGLYTHHQLGVGMAVPMSPMQKPPLQQQLLQHRLLQQKRQL 1219
            |          ||   |..||                         ..|:|||.:|| |||||..
  Rat   697 P----------MY---CKEPP-------------------------RSLEQQLQEHR-LQQKRLF 722

  Fly  1220 FQKQYALEA-----QLAGRHH--HHQQHSHHHHHHFGHSLGPPPPPAPAPEHHLADELYE-LALL 1276
            .|||..|:|     |:|.|.:  ..||.:..|           |..||.|:...:..|.: |:.:
  Rat   723 LQKQSQLQAYFNQMQIAERSYPGPTQQLALPH-----------PETAPTPQQPPSFSLTQALSPV 776

  Fly  1277 DRPRSGTPRLQHSMTMPGAHAFSQMNLK--------------TSYISQSDQVPGAAPNGAGSGGS 1327
            ..|.|...|....::.     :..|.|:              .|.:.|..|.|...|
  Rat   777 LEPSSEQMRFSSFLSQ-----YPDMQLQPLPSTPSPRAPPPLPSQLQQQQQPPPPPP-------- 828

  Fly  1328 AAGVSCSAPPSTAPG-TP--------------TVKCKPTTPHGHSLDSDYHTSTPVLSLFTPNWQ 1377
                   .||...|| ||              |....|:.|.......|....:.:.....|...
  Rat   829 -------PPPPQQPGATPASLQFSYQTCGLPSTTSSAPSYPASCHYPVDGAQQSNLTGAECPRSS 886

  Fly  1378 SLVKPLSESPILEISEHLESV 1398
            .|.:.||..|.|...|.:|:|
  Rat   887 GLQEALSALPGLFDYEMVEAV 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	195/251 (78%)
		UBA_SIK	418..458	CDD:270523	18/39 (46%)
Sik2	NP_001414257.1	None