Protein Alignment Sik2 and HUNK

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_055401.1
• Gene: HUNK / 30811
• HGNCID: 13326
• Length: 714
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 211/763 - (27%)
• Similarity: 325/763 - (42%)
• Gaps: 160/763 - (20%)

  Fly    91 ACKDALLAQKLF-ASGGGSTPGPSPTSSAVGA------GGISGKDLLKLKEPMRVGFYDI-ERTI 147
            |..|.||.:... ..|||:.....|.::..|:      .|:..:.|...:...|||.|.| .|.:
Human     4 AAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKL 68

  Fly   148 GKGNFAVVKLARHRITKNEVAIKIIDK--SQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETK 210
            |:|:||.|:...|.:|..:||||:|||  ::.|....:.:.||.:|.:.::||:|.:|..::||:
Human    69 GEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETE 133

  Fly   211 NMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNM 275
            |..|:|.|....|.:...|.:..|:.||.||....|:|||||:.|:.|:||||||.||||||.:.
Human   134 NSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDN 198

  Fly   276 NIKIADFGFSN------HFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCG 334
            |||:.|||.||      :..|   .:|.||||.|||||:...|:| ||:||:||:||.:|.::.|
Human   199 NIKLIDFGLSNCAGILGYSDP---FSTQCGSPAYAAPELLARKKY-GPKIDVWSIGVNMYAMLTG 259

  Fly   335 ALPF--DGSTLQSLRDRVLSGRFR-IPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPEL 396
            .|||  :..:|::|..:::..... :|..:|:.....:|.:|..:|.:|..|.|...:||:....
Human   260 TLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENY 324

  Fly   397 LEHVLIAKYNLGAERQTSVEP-SEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLL----- 455
            ...|   ..|:....:.|:|. |..::..|.|.:|..:.....::..|...|:.|||.||
Human   325 TGKV---PCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLE 386

  Fly   456 ---------QDRVSHKK-----EQSNGLGASALASSTSASR-MIYSSRNDHQPTQQQSQQQSKTI 505
                     ||.:.:|.     |:......|..||..:.:| :.:.:..|.:|.:|:.:......
Human   387 RYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHR 451

  Fly   506 STSSILAKD-QCHKRLS-------RHQTVLMSERNAHAGATPTVPDPG-PGYYAKYGPLQLPLPL 561
            ..|..|.|: ..||:.|       ::...|:.:|.|...:.|.....| ...:.|
Human   452 PFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRK---------- 506

  Fly   562 TGHSHLTGYLNGGGVEVDASGIPLPMRYTP----LPTAASPAPSNCSSTSSRVGRHSLSSSSPRS 622
            |..|:...   ...:|.    ||:|...||    .|....|.|.              |:..|..
Human   507 TSDSNCVA---SSSMEF----IPVPPPRTPRIVKKPEPHQPGPG--------------STGIPHK 550

  Fly   623 HRPVAISL-----SID-----------------NNP-SLANLRCREMMEAGGGPVGAVGVPLASK 664
            ..|:.:.:     |:|                 |:| |||.....|...:.|.|.|::. ||.:
Human   551 EDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMS-PLHT- 613

  Fly   665 QLHQTISEFIIKQSTEDCRALLQQSTAVAEGKDDPPKAESSVGGVPPPASTTPTSSTAGPESGSA 729
            .||.|:..|                  ..|.|:.|||.|...  .|||   .|::....| .||.
Human   614 PLHPTLVSF------------------AHEDKNSPPKEEGLC--CPPP---VPSNGPMQP-LGSP 654

  Fly   730 PCPGEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQES 777
            .|           :.|...| ....:||..|        |..|:||.|
Human   655 NC-----------VKSRGRF-PMMGIGQMLR--------KRHQSLQPS 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	103/263 (39%)
		UBA_SIK	418..458	CDD:270523	12/53 (23%)
HUNK	NP_055401.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		7/21 (33%)
		STKc_HUNK	58..320	CDD:270972	105/265 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	437..471		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	518..552		11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	590..615		7/26 (27%)