Protein Alignment Sik2 and Smokl1

DIOPT Version :10

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: XP_218667.4
• Gene: Smokl1 / 292948
• RGDID: 1560303
• Length: 494
• Species: Rattus norvegicus
• Alignment Length: 417
• Identity: 142/417 - (34%)
• Similarity: 206/417 - (49%)
• Gaps: 42/417 - (10%)

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            |.|.:.:|:|....|:|:.||:|...||:|.:.|   .:.:......||||||.|.|.:|:.|.|
  Rat    29 YTILKPLGQGGTTEVRLSSHRLTGTPVAVKALVK---HERHWASTMSEVEIMKILNHNNIVSLLQ 90

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            ||||:..|||:.|.|....:.:.:.|.||:.|..||..|.|::||:.|||.|||:|||||.:|::
  Rat    91 VMETEQNIYIIMEVAQGDSLLNRVQKAGRLKEDEARGIFVQLLSALGYCHGKGIIHRDLKPDNII 155

  Fly   271 LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGA 335
            :|.:.|:||.|||....|.||:.|...||:..:..||:|.|..|.||::|||:|||:||.:|.|.
  Rat   156 VDEHGNVKIIDFGLGAKFLPGQKLKRLCGAFQFIPPELFLGLPYDGPKVDIWALGVLLYFMVTGF 220

  Fly   336 LPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM---CPELL 397
            .||.|:||..|...||.||:.||:.:|.:...:|..:|.:...:|.|...:..|.|:   ...|.
  Rat   221 APFSGTTLSELSKNVLQGRYDIPYNLSKDLRSMISLLLTVNARQRPTAQDLSSHPWLQEWGKTLT 285

  Fly   398 EHVLIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHK 462
            .|         :.|.||. |:.||: :..|.:|......:.|||...:|...|.||||  ||...
  Rat   286 FH---------SNRDTSF-PNRDIM-VAMENIGFHVQDIKESLKHKKFDETMATYLLL--RVQAC 337

  Fly   463 KEQSNGLGASALASSTSASRMIYSSRNDHQ-----PTQQQSQQQSKTISTSSILAKDQCHKRLSR 522
            :...|.:....|....:.    :.|..|..     |.::.|:...|.:..||
  Rat   338 QNGGNYVQTKLLNPGVAP----FPSAADPDTFPLPPRRRASEPSLKIVVASS------------- 385

  Fly   523 HQTVLMSERNAHAGATP-TVPDPGPGY 548
            .|..|......:|...| ..|..|.||
  Rat   386 EQQRLRQSGGTNAPVQPKKTPVMGRGY 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	103/250 (41%)
		UBA_SIK	418..458	CDD:270523	13/39 (33%)
Smokl1	XP_218667.4	STKc_AMPK-like	28..276	CDD:270905	103/249 (41%)
		UBA_MARK_Par1	295..332	CDD:270522	12/37 (32%)