Protein Alignment Sik2 and RGD1562638

DIOPT Version :9

• Sequence 1: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Sequence 2: NP_001094414.1
• Gene: RGD1562638 / 290818
• RGDID: 1562638
• Length: 654
• Species: Rattus norvegicus
• Alignment Length: 637
• Identity: 186/637 - (29%)
• Similarity: 278/637 - (43%)
• Gaps: 115/637 - (18%)

  Fly   141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQ 205
            |.|..::|:|.|..||||.|.:|:.:||||::.||   ..|| .:..|:||||.|.|||||||..
  Rat    24 YRILASLGQGGFGEVKLASHLLTQTKVAIKVLPKS---NKNL-LLKSEIEIMKSLDHPHIIKLLH 84

  Fly   206 VMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLL 270
            :::|...|:||.|:|..||:...|..:|.:.|......|.|::.|::|||::||:|||:|.||:|
  Rat    85 IIDTNENIFIVLEHAVGGELLTRIEDFGYLPEEECNRLFRQMVLALQYCHQRGIIHRDIKPENIL 149

  Fly   271 LDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGA 335
            ||...|:|::|||.|.....|:.|.|.||:.||.|||:|....|.|..||:||||||||.:..|.
  Rat   150 LDHKGNVKLSDFGLSTKIVMGQKLTTLCGTLPYCAPELFNLNGYDGQAIDVWSLGVVLYYMATGC 214

  Fly   336 LPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPELLEHV 400
            |||.|.|.|:::.::||||:.:.|.:|.:...:|.::|.:.|..|..:.:|.|..|    |....
  Rat   215 LPFQGFTYQAIKQKILSGRYSVNFRLSPDLWDVIAKLLTVNPRERPRVHEILRFNW----LKNEN 275

  Fly   401 LIAKYNLGAERQTSVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRV-----S 460
            .::..:||.  .|...|...||.:|.: :|....:.|.||::..:|.|.|.||:|:::.     |
  Rat   276 EVSPSSLGG--NTDSHPDPTILVMMGD-MGYEQGQIRESLRERKFDQVMATYLMLREKACSEDKS 337

  Fly   461 HKKEQSNGLGASALASSTSASRMIYSSRNDHQPTQQQSQQQSKTISTSSILAKDQCHKRLSRHQT 525
            .|.........:..::.::..:.....|....||.......||..|    |.|::  :...||
  Rat   338 IKTPHPTQCAQTLKSTGSTTEKQTTLRRGSSLPTLTTFYLPSKLES----LNKEK--RTTMRH-- 394

  Fly   526 VLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGY--------------LNGGGV 576
                          |:| |....:.|...|.     .|...:..:              ||.|..
  Rat   395 --------------TMP-PNLNCFNKSESLN-----KGRRTIVSHTISPTLNCFNKSESLNKGKR 439

  Fly   577 EVDASGIPLPMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANL 641
            .:        :|:|..|...||....|.......|..|.|..|.:.:         .::|||...
  Rat   440 TI--------VRHTMPPKKTSPVRRICPRLHKSFGMGSASEDSSKRN---------SSDPSLTIF 487

  Fly   642 RCREMMEA--GGGPVGAVGVPLASKQLHQTISEFIIKQSTEDCRALLQQSTAVAEGK-------- 696
            ..:..|.|  .|....      ..|...|.|..:...|..:.     .::|.:..||
  Rat   488 SSQSFMSAFKYGSTYS------KRKAFLQCILHYHASQEEDQ-----YKTTIIPSGKLNTTVPPN 541

  Fly   697 ---DDPPKAE----SSVGGV--------PPPASTTPTSSTAGP---ESGSAP 730
               :|.|...    .:.|.|        .||.|||.|.. .||   |..|.|
  Rat   542 SLQEDQPTGHLHNVLTAGAVDNRNLQEKSPPFSTTATKG-EGPAIKERESIP 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	108/250 (43%)
		S_TKc	141..392	CDD:214567	108/250 (43%)
RGD1562638	NP_001094414.1	STKc_AMPK-like	23..270	CDD:270905	108/249 (43%)
		UBA_MARK_Par1	290..329	CDD:270522	14/39 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..369		3/32 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	563..616		11/31 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810